Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)

Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII (R)), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi...

Descripción completa

Detalles Bibliográficos
Autores: Obon-Santacana, Mireia, Romaguera, Dora, Gracia-Lavedan, Esther, Molinuevo, Amaia, Molina-Montes, Esther, Shivappa, Nitin, Hebert, James R., Tardon, Adonina, Castaño-Vinyals G, Moratalla, Ferran, Guino, Elisabet, Marcos-Gragera, Rafael, Azpiri, Mikel, Gil, Leire, Olmedo-Requena, Rocio, Lozano-Lorca, Macarena, Alguacil, Juan, Fernandez-Villa, Tania, Martin, Vicente, Molina, Antonio J., Ederra, Maria, Moreno-Iribas, Conchi, Perez, Beatriz, Aragones, Nuria, Castello, Adela, Huerta, Jose Ma, Dierssen-Sotos, Trinidad, Gomez-Acebo, Ines, Molina-Barcelo, Ana, Pollan, Marina, Kogevinas, Manolis, Moreno, Victor, Amiano, Pilar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p3725
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/3725
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068795068&doi=10.3390%2fnu11061406&partnerID=40&md5=56846621b2c9f90d99e98eb9d5b55efb
Access Level:acceso abierto
Palabra clave:colorectal cancer
breast cancer
diet
dietary inflammatory index
antioxidants
NEAC
case-control study
MCC-Spain
Descripción
Sumario:Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII (R)), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99-1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.

Similares en LA Referencia