Bacterial toxin-antitoxin systems targeting translation

10 p.-2 fig.

Detalhes bibliográficos
Autores: Díaz-Orejas, Ramón, Diago-Navarro, Elizabeth, Hernández-Arriaga, A.M., López-Villarejo, Juan, Lemonnier, Marc, Moreno-Córdoba, Inmaculada, Nieto, Concha, Espinosa, Manuel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/116159
Acesso em linha:http://hdl.handle.net/10261/116159
Access Level:acceso abierto
Palavra-chave:Toxin-antitoxin systems
Plasmid maintenance
Cell growth regulation
Toxin RNases
Protein synthesis inhibition
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spelling Bacterial toxin-antitoxin systems targeting translationDíaz-Orejas, RamónDiago-Navarro, ElizabethHernández-Arriaga, A.M.López-Villarejo, JuanLemonnier, MarcMoreno-Córdoba, InmaculadaNieto, ConchaEspinosa, ManuelToxin-antitoxin systemsPlasmid maintenanceCell growth regulationToxin RNasesProtein synthesis inhibition10 p.-2 fig.Toxin-antitoxin systems (TAS) emerged more than 25 years ago and have since developed as an important field in molecular microbiology. TAS are autoregulated operons coding a stable toxin and an unstable antitoxin found in the plasmids and chromosomes of Bacteria and Archaea. The conditional activation of their toxins interferes with cell growth/viability and, depending on the context, can influence plasmid maintenance,stress management, bacterial persistence, cell differentiation and, it is likely also bacterial virulence. This review summarizes recent results on the parD system of plasmid R1 and on the chromosomal relBE systems found in Escherichia coli and in Streptococcus pneumoniae with a focus on the RNase activity of their toxins,their regulation and their biomedical applications and implications.The authors acknowledge the financial support of the MICINN, the Spanish Ministry of Science and Innovation, (CSD2008-00013; BFU2008- 00179-E/BMC)Peer reviewedElsevierMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201520152010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/116159reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/ 10.2478/v10136-009-0021-9Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1161592026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bacterial toxin-antitoxin systems targeting translation
title Bacterial toxin-antitoxin systems targeting translation
spellingShingle Bacterial toxin-antitoxin systems targeting translation
Díaz-Orejas, Ramón
Toxin-antitoxin systems
Plasmid maintenance
Cell growth regulation
Toxin RNases
Protein synthesis inhibition
title_short Bacterial toxin-antitoxin systems targeting translation
title_full Bacterial toxin-antitoxin systems targeting translation
title_fullStr Bacterial toxin-antitoxin systems targeting translation
title_full_unstemmed Bacterial toxin-antitoxin systems targeting translation
title_sort Bacterial toxin-antitoxin systems targeting translation
dc.creator.none.fl_str_mv Díaz-Orejas, Ramón
Diago-Navarro, Elizabeth
Hernández-Arriaga, A.M.
López-Villarejo, Juan
Lemonnier, Marc
Moreno-Córdoba, Inmaculada
Nieto, Concha
Espinosa, Manuel
author Díaz-Orejas, Ramón
author_facet Díaz-Orejas, Ramón
Diago-Navarro, Elizabeth
Hernández-Arriaga, A.M.
López-Villarejo, Juan
Lemonnier, Marc
Moreno-Córdoba, Inmaculada
Nieto, Concha
Espinosa, Manuel
author_role author
author2 Diago-Navarro, Elizabeth
Hernández-Arriaga, A.M.
López-Villarejo, Juan
Lemonnier, Marc
Moreno-Córdoba, Inmaculada
Nieto, Concha
Espinosa, Manuel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Toxin-antitoxin systems
Plasmid maintenance
Cell growth regulation
Toxin RNases
Protein synthesis inhibition
topic Toxin-antitoxin systems
Plasmid maintenance
Cell growth regulation
Toxin RNases
Protein synthesis inhibition
description 10 p.-2 fig.
publishDate 2010
dc.date.none.fl_str_mv 2010
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/116159
url http://hdl.handle.net/10261/116159
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/ 10.2478/v10136-009-0021-9
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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