MOG Antibodies Restricted to CSF in Children With Inflammatory CNS Disorders

Objectives To assess the clinical significance of myelin oligodendrocyte glycoprotein antibodies (MOG-abs) restricted to CSF in children with inflammatory CNS disorders. Methods Patients included 760 children (younger than 18 years) from 3 multicenter prospective cohort studies: (A) acquired demyeli...

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Detalles Bibliográficos
Autores: Olivé Cirera, Gemma, Bruijstens, Arlette L., Fonseca, Elianet G., Chen, Li-Wen, Caballero, Eva, Martinez Hernandez, Eugenia, Guasp, Mar, Sepúlveda, María, Naranjo, Laura, Ruiz García, Raquel, Blanco Morgado, Yolanda, Saiz, Albert, Dalmau Obrador, Josep, Armangué, Thaís
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/218737
Acceso en línea:https://hdl.handle.net/2445/218737
Access Level:acceso abierto
Palabra clave:Malalties del sistema nerviós central
Glicoproteïnes
Malalties dels infants
Central nervous system diseases
Glycoproteins
Children's diseases
Descripción
Sumario:Objectives To assess the clinical significance of myelin oligodendrocyte glycoprotein antibodies (MOG-abs) restricted to CSF in children with inflammatory CNS disorders. Methods Patients included 760 children (younger than 18 years) from 3 multicenter prospective cohort studies: (A) acquired demyelinating syndromes, including acute disseminated encephalomy- elitis (ADEM); (B) non-ADEM encephalitis; and (C) noninflammatory neurologic disorders. For all cases, paired serum/CSF samples were systematically examined using brain immuno- histochemistry and live cell-based assays. Results A total of 109 patients (14%) had MOG-abs in serum or CSF: 79 from cohort A, 30 from B, and none from C. Of these, 63 (58%) had antibodies in both samples, 37 (34%) only in serum, and 9 (8%) only in CSF. Children with MOG-abs only in CSF were older than those with MOG-abs only in serum or in both samples (median 12 vs 6 vs 5 years, p = 0.0002) and were more likely to have CSF oligoclonal bands (86% vs 12% vs 7%, p = 0.0001) and be diagnosed with multiple sclerosis (6/9 [67%] vs 0/37 [0%] vs 1/63 [2%], p < 0.0001). Discussion Detection of MOG-abs in serum or CSF is associated with CNS inflammatory disorders. Children with MOG-abs restricted to CSF are more likely to have CSF oligoclonal bands and multiple sclerosis than those with MOG-abs detectable in serum.

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