Cutaneous Allodynia in Migraine
In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over t...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:256023 |
| Acceso en línea: | https://ddd.uab.cat/record/256023 https://dx.doi.org/urn:doi:10.3389/fneur.2021.831035 |
| Access Level: | acceso abierto |
| Palabra clave: | Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
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Cutaneous Allodynia in MigraineA Narrative ReviewMínguez-Olaondo, Ane|||0000-0002-7742-3920Quintas, Sonia|||0000-0003-0622-8228Morollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210López-Bravo, Alba|||0000-0002-2465-2316Vila-Pueyo, Marta|||0000-0003-0652-2988Grozeva, VesselinaBelvís, Roberto|||0000-0002-2137-180XSantos Lasaosa, Sonia|||0000-0002-4141-7705Irimia, Pablo|||0000-0002-7238-0036Cutaneous allodyniaMigraineMigraine chronificationRisk factorsTreatmentIn the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. We performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. The prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. CA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256023https://dx.doi.org/urn:doi:10.3389/fneur.2021.831035reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2560232026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Cutaneous Allodynia in Migraine A Narrative Review |
| title |
Cutaneous Allodynia in Migraine |
| spellingShingle |
Cutaneous Allodynia in Migraine Mínguez-Olaondo, Ane|||0000-0002-7742-3920 Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
| title_short |
Cutaneous Allodynia in Migraine |
| title_full |
Cutaneous Allodynia in Migraine |
| title_fullStr |
Cutaneous Allodynia in Migraine |
| title_full_unstemmed |
Cutaneous Allodynia in Migraine |
| title_sort |
Cutaneous Allodynia in Migraine |
| dc.creator.none.fl_str_mv |
Mínguez-Olaondo, Ane|||0000-0002-7742-3920 Quintas, Sonia|||0000-0003-0622-8228 Morollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210 López-Bravo, Alba|||0000-0002-2465-2316 Vila-Pueyo, Marta|||0000-0003-0652-2988 Grozeva, Vesselina Belvís, Roberto|||0000-0002-2137-180X Santos Lasaosa, Sonia|||0000-0002-4141-7705 Irimia, Pablo|||0000-0002-7238-0036 |
| author |
Mínguez-Olaondo, Ane|||0000-0002-7742-3920 |
| author_facet |
Mínguez-Olaondo, Ane|||0000-0002-7742-3920 Quintas, Sonia|||0000-0003-0622-8228 Morollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210 López-Bravo, Alba|||0000-0002-2465-2316 Vila-Pueyo, Marta|||0000-0003-0652-2988 Grozeva, Vesselina Belvís, Roberto|||0000-0002-2137-180X Santos Lasaosa, Sonia|||0000-0002-4141-7705 Irimia, Pablo|||0000-0002-7238-0036 |
| author_role |
author |
| author2 |
Quintas, Sonia|||0000-0003-0622-8228 Morollón Sánchez-Mateos, Noemí|||0000-0003-4256-4210 López-Bravo, Alba|||0000-0002-2465-2316 Vila-Pueyo, Marta|||0000-0003-0652-2988 Grozeva, Vesselina Belvís, Roberto|||0000-0002-2137-180X Santos Lasaosa, Sonia|||0000-0002-4141-7705 Irimia, Pablo|||0000-0002-7238-0036 |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
| topic |
Cutaneous allodynia Migraine Migraine chronification Risk factors Treatment |
| description |
In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. CA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. We performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. The prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. CA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
Article de revisió http://purl.org/coar/resource_type/c_dcae04bc VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/256023 https://dx.doi.org/urn:doi:10.3389/fneur.2021.831035 |
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https://ddd.uab.cat/record/256023 https://dx.doi.org/urn:doi:10.3389/fneur.2021.831035 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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