Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup

Depressive symptoms following a stressful life event, such as a relationship breakup, are common, and constitute a potent risk factor for the onset of a major depressive episode. Resting-state neuroimaging studies have increasingly identified abnormal whole-brain communication in patients with depre...

ver descrição completa

Detalhes bibliográficos
Autores: Alonso Martínez, Sonsoles, Marsman, Jan-Bernard C., Kringelbach, Morten L., Deco, Gustavo, ter Horst, Gert J.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/45088
Acesso em linha:http://hdl.handle.net/10230/45088
http://dx.doi.org/10.1016/j.nicl.2020.102299
Access Level:acceso abierto
Palavra-chave:Resting-state fMRI
Global integration
Spatiotemporal dynamics
Whole-brain
Depressive symptoms
Non-clinical sample
id ES_136b4e1d6a092b5a373539f3b4eea828
oai_identifier_str oai:repositori.upf.edu:10230/45088
network_acronym_str ES
network_name_str España
repository_id_str
spelling Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakupAlonso Martínez, SonsolesMarsman, Jan-Bernard C.Kringelbach, Morten L.Deco, Gustavoter Horst, Gert J.Resting-state fMRIGlobal integrationSpatiotemporal dynamicsWhole-brainDepressive symptomsNon-clinical sampleDepressive symptoms following a stressful life event, such as a relationship breakup, are common, and constitute a potent risk factor for the onset of a major depressive episode. Resting-state neuroimaging studies have increasingly identified abnormal whole-brain communication in patients with depression, but it is currently unclear whether depressive symptoms in individuals without a clinical diagnosis have reliable neural underpinnings. We investigated to what extent the severity of depressive symptoms in a non-clinical sample was associated with imbalances in the complex dynamics of the brain during rest. To this end, a novel intrinsic ignition approach was applied to resting-state neuroimaging data from sixty-nine participants with varying degrees of depressive symptoms following a relationship breakup. Ignition-based measures of integration, hierarchy, and metastability were calculated for each participant, revealing a negative correlation between these measures and depressive ratings. We found that the severity of depressive symptoms was associated with deficits in the brain’s capacity to globally integrate and process information over time. Furthermore, we found that increased depressive symptoms were associated with reduced spatial diversity (i.e., hierarchy) and reduced temporal variability (i.e., metastability) in the functional organization of the brain. These findings suggest the merit of investigating constrained dynamical complexity as it is sensitive to the level of depressive symptoms even in a non-clinical sample.This work was funded by a donation of Mr. Hazewinkel to Prof. dr. Gert J. ter Horst and the Research School of Behavioural and Cognitive Neurosciences, University of Groningen, the Netherlands. The funder had no role in study design, the collection, analysis and, interpretation of data, the decision to publish, or the writing of the manuscript.Elsevier202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/45088http://dx.doi.org/10.1016/j.nicl.2020.102299reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeuroImage: clinical. 2020 May 26;27:102299© 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).http://creativecommons.org/licenses/BY-NC-ND/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/450882026-06-12T07:21:37Z
dc.title.none.fl_str_mv Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
title Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
spellingShingle Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
Alonso Martínez, Sonsoles
Resting-state fMRI
Global integration
Spatiotemporal dynamics
Whole-brain
Depressive symptoms
Non-clinical sample
title_short Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
title_full Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
title_fullStr Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
title_full_unstemmed Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
title_sort Reduced spatiotemporal brain dynamics are associated with increased depressive symptoms after a relationship breakup
dc.creator.none.fl_str_mv Alonso Martínez, Sonsoles
Marsman, Jan-Bernard C.
Kringelbach, Morten L.
Deco, Gustavo
ter Horst, Gert J.
author Alonso Martínez, Sonsoles
author_facet Alonso Martínez, Sonsoles
Marsman, Jan-Bernard C.
Kringelbach, Morten L.
Deco, Gustavo
ter Horst, Gert J.
author_role author
author2 Marsman, Jan-Bernard C.
Kringelbach, Morten L.
Deco, Gustavo
ter Horst, Gert J.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Resting-state fMRI
Global integration
Spatiotemporal dynamics
Whole-brain
Depressive symptoms
Non-clinical sample
topic Resting-state fMRI
Global integration
Spatiotemporal dynamics
Whole-brain
Depressive symptoms
Non-clinical sample
description Depressive symptoms following a stressful life event, such as a relationship breakup, are common, and constitute a potent risk factor for the onset of a major depressive episode. Resting-state neuroimaging studies have increasingly identified abnormal whole-brain communication in patients with depression, but it is currently unclear whether depressive symptoms in individuals without a clinical diagnosis have reliable neural underpinnings. We investigated to what extent the severity of depressive symptoms in a non-clinical sample was associated with imbalances in the complex dynamics of the brain during rest. To this end, a novel intrinsic ignition approach was applied to resting-state neuroimaging data from sixty-nine participants with varying degrees of depressive symptoms following a relationship breakup. Ignition-based measures of integration, hierarchy, and metastability were calculated for each participant, revealing a negative correlation between these measures and depressive ratings. We found that the severity of depressive symptoms was associated with deficits in the brain’s capacity to globally integrate and process information over time. Furthermore, we found that increased depressive symptoms were associated with reduced spatial diversity (i.e., hierarchy) and reduced temporal variability (i.e., metastability) in the functional organization of the brain. These findings suggest the merit of investigating constrained dynamical complexity as it is sensitive to the level of depressive symptoms even in a non-clinical sample.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/45088
http://dx.doi.org/10.1016/j.nicl.2020.102299
url http://hdl.handle.net/10230/45088
http://dx.doi.org/10.1016/j.nicl.2020.102299
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv NeuroImage: clinical. 2020 May 26;27:102299
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/BY-NC-ND/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/BY-NC-ND/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403674965442560
score 15.812429

Registos relacionados