Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features

The intestinal microbiota is a complex community that plays an important role in human health from the initial steps of its establishment. Its microbial composition has been suggested to result from selective pressures imposed by the host and is modulated by competition among its members. Bifidobact...

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Autores: Arboleya, Silvia, Stanton, Catherine, Ryan, C. Anthony, Dempsey, Eugene, Ross, Paul R.
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/346029
Acceso en línea:http://hdl.handle.net/10261/346029
Access Level:acceso abierto
Palabra clave:Bifidobacteria
Probiotics
Infants
Gut
Microbiota
Homeostasis
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spelling Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic FeaturesArboleya, SilviaStanton, CatherineRyan, C. AnthonyDempsey, EugeneRoss, Paul R.BifidobacteriaProbioticsInfantsGutMicrobiotaHomeostasisThe intestinal microbiota is a complex community that plays an important role in human health from the initial steps of its establishment. Its microbial composition has been suggested to result from selective pressures imposed by the host and is modulated by competition among its members. Bifidobacterium longum is one of the most abundant species of the Bifidobacterium genus in the gut microbiota of healthy breast-fed infants and adults. The recent advancements of ‘omics techniques have facilitated the genetic and functional studies of different gut microbiota members. They have revealed the complex genetic pathways used to metabolize different compounds that likely contribute to the competitiveness and persistence of B. longum in the colon. The discovery of a genomic island in B. longum ssp. infantis that encodes specific enzymes for the metabolism of human milk oligosaccharides suggests a specific ecological adaptation. Moreover, B. longum is widely used as probiotic, and beneficial effects in infant health have been reported in several studies.The authors and this work were supported by the Science Foundation Ireland (SFI)-funded APC Microbiome Institute; by SFI (Infant 12/RC/2272); by Department of Agriculture Food and Marine (DAFM)-funded INFANTMET (Ref. No. 10FDairy) and ToddlerFood (Ref. No. 14F821) projects; and by European Union's Seventh Framework Program (EUFP7)-funded MyNewGut project (Ref. No. 613979).Peer reviewedAnnual ReviewsScience Foundation IrelandDepartment of Agriculture, Food and Marine (Ireland)European Commission202420242016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionapplication/pdfhttp://hdl.handle.net/10261/346029reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/613979https://doi.org/10.1146/annurev-food-041715-033151Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3460292026-05-22T06:33:51Z
dc.title.none.fl_str_mv Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
title Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
spellingShingle Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
Arboleya, Silvia
Bifidobacteria
Probiotics
Infants
Gut
Microbiota
Homeostasis
title_short Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
title_full Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
title_fullStr Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
title_full_unstemmed Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
title_sort Bosom Buddies: The Symbiotic Relationship Between Infants and Bifidobacterium longum ssp. longum and ssp. infantis. Genetic and Probiotic Features
dc.creator.none.fl_str_mv Arboleya, Silvia
Stanton, Catherine
Ryan, C. Anthony
Dempsey, Eugene
Ross, Paul R.
author Arboleya, Silvia
author_facet Arboleya, Silvia
Stanton, Catherine
Ryan, C. Anthony
Dempsey, Eugene
Ross, Paul R.
author_role author
author2 Stanton, Catherine
Ryan, C. Anthony
Dempsey, Eugene
Ross, Paul R.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Science Foundation Ireland
Department of Agriculture, Food and Marine (Ireland)
European Commission
dc.subject.none.fl_str_mv Bifidobacteria
Probiotics
Infants
Gut
Microbiota
Homeostasis
topic Bifidobacteria
Probiotics
Infants
Gut
Microbiota
Homeostasis
description The intestinal microbiota is a complex community that plays an important role in human health from the initial steps of its establishment. Its microbial composition has been suggested to result from selective pressures imposed by the host and is modulated by competition among its members. Bifidobacterium longum is one of the most abundant species of the Bifidobacterium genus in the gut microbiota of healthy breast-fed infants and adults. The recent advancements of ‘omics techniques have facilitated the genetic and functional studies of different gut microbiota members. They have revealed the complex genetic pathways used to metabolize different compounds that likely contribute to the competitiveness and persistence of B. longum in the colon. The discovery of a genomic island in B. longum ssp. infantis that encodes specific enzymes for the metabolism of human milk oligosaccharides suggests a specific ecological adaptation. Moreover, B. longum is widely used as probiotic, and beneficial effects in infant health have been reported in several studies.
publishDate 2016
dc.date.none.fl_str_mv 2016
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/346029
url http://hdl.handle.net/10261/346029
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/613979
https://doi.org/10.1146/annurev-food-041715-033151
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Annual Reviews
publisher.none.fl_str_mv Annual Reviews
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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