Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit

A new series of amphiphilic block copolymers has been prepared by ring opening polymerization (ROP) of cyclic carbonates using PEG as initiator. The light responsive unit [7–(diethylaminocoumarin)–4–yl]methyl ester has been introduced by a modular and versatile supramolecular approach, while a refer...

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Detalles Bibliográficos
Autores: Roche, Alejandro, Terriac, Emmanuel, Tejedor, Rosa M., Oriol, Luis, Campo, Aránzazu del, Piñol, Milagros
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/219134
Acceso en línea:http://hdl.handle.net/10261/219134
Access Level:acceso abierto
Palabra clave:Light responsive
Nanocarriers
Block copolymers
Coumarins
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spelling Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unitRoche, AlejandroTerriac, EmmanuelTejedor, Rosa M.Oriol, LuisCampo, Aránzazu delPiñol, MilagrosLight responsiveNanocarriersBlock copolymersCoumarinsA new series of amphiphilic block copolymers has been prepared by ring opening polymerization (ROP) of cyclic carbonates using PEG as initiator. The light responsive unit [7–(diethylaminocoumarin)–4–yl]methyl ester has been introduced by a modular and versatile supramolecular approach, while a reference covalent copolymer has been synthesized for the shake of comparison. Synthesized copolymers showed monomodal narrow distributions and were able to self-assemble into spherical micelles when dispersed in water. UV irradiation allowed us the modification of the self-assemblies morphology, as proved by means of fluorescence spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). Both the supramolecular and covalent functionalized block copolymers were able to encapsulate small fluorescent probes as payload and to release them upon UV and NIR irradiation.This work was funded by the Ministerio de Economia y Competitividad of Spain (MINECO)-FEDER, under the project grant number MAT2017-84838-P, and Gobierno de Aragon-FEDER (Liquid Crystals and Polymers Group E47_17R, FEDER 2014–2020 “Construyendo Europa desde Aragón”).Peer reviewedElsevierMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/219134reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-84838-PMAT2017-84838-P/AEI/10.13039/501100011033https://doi.org/10.1016/j.eurpolymj.2020.109561Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2191342026-05-22T06:33:51Z
dc.title.none.fl_str_mv Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
title Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
spellingShingle Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
Roche, Alejandro
Light responsive
Nanocarriers
Block copolymers
Coumarins
title_short Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
title_full Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
title_fullStr Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
title_full_unstemmed Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
title_sort Supramolecular block copolymers as novel UV and NIR responsive nanocarriers based on a photolabile coumarin unit
dc.creator.none.fl_str_mv Roche, Alejandro
Terriac, Emmanuel
Tejedor, Rosa M.
Oriol, Luis
Campo, Aránzazu del
Piñol, Milagros
author Roche, Alejandro
author_facet Roche, Alejandro
Terriac, Emmanuel
Tejedor, Rosa M.
Oriol, Luis
Campo, Aránzazu del
Piñol, Milagros
author_role author
author2 Terriac, Emmanuel
Tejedor, Rosa M.
Oriol, Luis
Campo, Aránzazu del
Piñol, Milagros
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Light responsive
Nanocarriers
Block copolymers
Coumarins
topic Light responsive
Nanocarriers
Block copolymers
Coumarins
description A new series of amphiphilic block copolymers has been prepared by ring opening polymerization (ROP) of cyclic carbonates using PEG as initiator. The light responsive unit [7–(diethylaminocoumarin)–4–yl]methyl ester has been introduced by a modular and versatile supramolecular approach, while a reference covalent copolymer has been synthesized for the shake of comparison. Synthesized copolymers showed monomodal narrow distributions and were able to self-assemble into spherical micelles when dispersed in water. UV irradiation allowed us the modification of the self-assemblies morphology, as proved by means of fluorescence spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). Both the supramolecular and covalent functionalized block copolymers were able to encapsulate small fluorescent probes as payload and to release them upon UV and NIR irradiation.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/219134
url http://hdl.handle.net/10261/219134
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/MAT2017-84838-P
MAT2017-84838-P/AEI/10.13039/501100011033
https://doi.org/10.1016/j.eurpolymj.2020.109561
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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