Opposite cannabis-cognition associations in psychotic patients depending on family history

The objective of this study is to investigate cognitive performance in a first-episode psycho- sis sample, when stratifying the interaction by cannabis use and familial or non-familial psy- chosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode...

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Autores: González-Pinto, Ana, González Ortega, Itxaso, Alberich, Susana, Ruiz de Azúa, Sonia, Bernardo Arroyo, Miquel, Bioque Alcázar, Miquel, Cabrera, Bibiana, Corripio, Iluminada, Arango, Celso, Lobo, Antonio, Sánchez-Torres, Ana M., Cuesta, Manuel J., PEPs Group
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/106491
Acesso em linha:https://hdl.handle.net/2445/106491
Access Level:Acceso aberto
Palavra-chave:Cànnabis
Psicosi
Malalties hereditàries
Memòria
Cognició
Neuropsicologia clínica
Cannabis
Psychoses
Genetic diseases
Memory
Cognition
Clinical neuropsychology
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repository_id_str
spelling Opposite cannabis-cognition associations in psychotic patients depending on family historyGonzález-Pinto, AnaGonzález Ortega, ItxasoAlberich, SusanaRuiz de Azúa, SoniaBernardo Arroyo, MiquelBioque Alcázar, MiquelCabrera, BibianaCorripio, IluminadaArango, CelsoLobo, AntonioSánchez-Torres, Ana M.Cuesta, Manuel J.PEPs GroupCànnabisPsicosiMalalties hereditàriesMemòriaCognicióNeuropsicologia clínicaCannabisPsychosesGenetic diseasesMemoryCognitionClinical neuropsychologyThe objective of this study is to investigate cognitive performance in a first-episode psycho- sis sample, when stratifying the interaction by cannabis use and familial or non-familial psy- chosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family his- tory of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no fam- ily history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosisPublic Library of Science (PLoS)2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/106491Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0160949PLoS One, 2016, vol. 11, num. 8, p. e0160949https://doi.org/10.1371/journal.pone.0160949info:eu-repo/grantAgreement/EC/FP7/603196info:eu-repo/grantAgreement/EC/FP7/602478info:eu-repo/grantAgreement/EC/FP7/242114 info:eu-repo/grantAgreement/EC/FP7/241909 cc-by (c) González Pinto, Ana et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1064912026-05-29T05:05:01Z
dc.title.none.fl_str_mv Opposite cannabis-cognition associations in psychotic patients depending on family history
title Opposite cannabis-cognition associations in psychotic patients depending on family history
spellingShingle Opposite cannabis-cognition associations in psychotic patients depending on family history
González-Pinto, Ana
Cànnabis
Psicosi
Malalties hereditàries
Memòria
Cognició
Neuropsicologia clínica
Cannabis
Psychoses
Genetic diseases
Memory
Cognition
Clinical neuropsychology
title_short Opposite cannabis-cognition associations in psychotic patients depending on family history
title_full Opposite cannabis-cognition associations in psychotic patients depending on family history
title_fullStr Opposite cannabis-cognition associations in psychotic patients depending on family history
title_full_unstemmed Opposite cannabis-cognition associations in psychotic patients depending on family history
title_sort Opposite cannabis-cognition associations in psychotic patients depending on family history
dc.creator.none.fl_str_mv González-Pinto, Ana
González Ortega, Itxaso
Alberich, Susana
Ruiz de Azúa, Sonia
Bernardo Arroyo, Miquel
Bioque Alcázar, Miquel
Cabrera, Bibiana
Corripio, Iluminada
Arango, Celso
Lobo, Antonio
Sánchez-Torres, Ana M.
Cuesta, Manuel J.
PEPs Group
author González-Pinto, Ana
author_facet González-Pinto, Ana
González Ortega, Itxaso
Alberich, Susana
Ruiz de Azúa, Sonia
Bernardo Arroyo, Miquel
Bioque Alcázar, Miquel
Cabrera, Bibiana
Corripio, Iluminada
Arango, Celso
Lobo, Antonio
Sánchez-Torres, Ana M.
Cuesta, Manuel J.
PEPs Group
author_role author
author2 González Ortega, Itxaso
Alberich, Susana
Ruiz de Azúa, Sonia
Bernardo Arroyo, Miquel
Bioque Alcázar, Miquel
Cabrera, Bibiana
Corripio, Iluminada
Arango, Celso
Lobo, Antonio
Sánchez-Torres, Ana M.
Cuesta, Manuel J.
PEPs Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cànnabis
Psicosi
Malalties hereditàries
Memòria
Cognició
Neuropsicologia clínica
Cannabis
Psychoses
Genetic diseases
Memory
Cognition
Clinical neuropsychology
topic Cànnabis
Psicosi
Malalties hereditàries
Memòria
Cognició
Neuropsicologia clínica
Cannabis
Psychoses
Genetic diseases
Memory
Cognition
Clinical neuropsychology
description The objective of this study is to investigate cognitive performance in a first-episode psycho- sis sample, when stratifying the interaction by cannabis use and familial or non-familial psy- chosis. Hierarchical-regression models were used to analyse this association in a sample of 268 first-episode psychosis patients and 237 controls. We found that cannabis use was associated with worse working memory, regardless of family history. However, cannabis use was clearly associated with worse cognitive performance in patients with no family his- tory of psychosis, in cognitive domains including verbal memory, executive function and global cognitive index, whereas cannabis users with a family history of psychosis performed better in these domains. The main finding of the study is that there is an interaction between cannabis use and a family history of psychosis in the areas of verbal memory, executive function and global cognition: that is, cannabis use is associated with a better performance in patients with a family history of psychosis and a worse performance in those with no fam- ily history of psychosis. In order to confirm this hypothesis, future research should explore the actual expression of the endocannabinoid system in patients with and without a family history of psychosis
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/106491
url https://hdl.handle.net/2445/106491
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0160949
PLoS One, 2016, vol. 11, num. 8, p. e0160949
https://doi.org/10.1371/journal.pone.0160949
info:eu-repo/grantAgreement/EC/FP7/603196
info:eu-repo/grantAgreement/EC/FP7/602478
info:eu-repo/grantAgreement/EC/FP7/242114
info:eu-repo/grantAgreement/EC/FP7/241909
dc.rights.none.fl_str_mv cc-by (c) González Pinto, Ana et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) González Pinto, Ana et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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