Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing

Adult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila, growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) ha...

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Detalles Bibliográficos
Autores: Shimell, M.J., Pan, X., Martín, Francisco A., Ghosh, A.C., Leopold, P., O’Connor, M.B, Romero, N.M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/219360
Acceso en línea:http://hdl.handle.net/10261/219360
Access Level:acceso abierto
Palabra clave:Drosophila development
Ecdysone
PTTH
Plasticity
Environmental cue
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spelling Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timingShimell, M.J.Pan, X.Martín, Francisco A.Ghosh, A.C.Leopold, P.O’Connor, M.BRomero, N.MDrosophila developmentEcdysonePTTHPlasticityEnvironmental cueAdult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila, growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this by examining the consequences of null mutations in the Ptth gene for Drosophila development. Loss of Ptth causes several developmental defects, including a delay in developmental timing, increase in critical weight, loss of coordination between body and imaginal disc growth, and reduced adult survival in suboptimal environmental conditions such as nutritional deprivation or high population density. These defects are caused by a decrease in ecdysone production associated with altered transcription of ecdysone biosynthetic genes. Therefore, the PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival.This work was supported by Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Fondation ARC pour la Recherche sur le Cancer grant PGA120150202355 and European Research Council Advanced Grant 268813 to P.L. and N.M.R.; and National Institutes of Health grant R35-GM118029 to M.B.O. F.A.M. is a recipient of Ramon y Cajal Contract RyC-2014-14961 from the Ministerio de Economıa y ́Competitividad and supported by BFU2014-54346-JIN.Company of BiologistsInstitut National de la Santé et de la Recherche Médicale (France)Centre National de la Recherche Scientifique (France)Fondation ARC pour la Recherche sur le CancerEuropean Research CouncilNational Institutes of Health (US)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020182020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/219360reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1242/dev.159699Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2193602026-05-22T06:33:51Z
dc.title.none.fl_str_mv Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
title Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
spellingShingle Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
Shimell, M.J.
Drosophila development
Ecdysone
PTTH
Plasticity
Environmental cue
title_short Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
title_full Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
title_fullStr Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
title_full_unstemmed Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
title_sort Prothoracicotropic hormone modulates environmental adaptive plasticity through the control of developmental timing
dc.creator.none.fl_str_mv Shimell, M.J.
Pan, X.
Martín, Francisco A.
Ghosh, A.C.
Leopold, P.
O’Connor, M.B
Romero, N.M
author Shimell, M.J.
author_facet Shimell, M.J.
Pan, X.
Martín, Francisco A.
Ghosh, A.C.
Leopold, P.
O’Connor, M.B
Romero, N.M
author_role author
author2 Pan, X.
Martín, Francisco A.
Ghosh, A.C.
Leopold, P.
O’Connor, M.B
Romero, N.M
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut National de la Santé et de la Recherche Médicale (France)
Centre National de la Recherche Scientifique (France)
Fondation ARC pour la Recherche sur le Cancer
European Research Council
National Institutes of Health (US)
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Drosophila development
Ecdysone
PTTH
Plasticity
Environmental cue
topic Drosophila development
Ecdysone
PTTH
Plasticity
Environmental cue
description Adult size and fitness are controlled by a combination of genetics and environmental cues. In Drosophila, growth is confined to the larval phase and final body size is impacted by the duration of this phase, which is under neuroendocrine control. The neuropeptide prothoracicotropic hormone (PTTH) has been proposed to play a central role in controlling the length of the larval phase through regulation of ecdysone production, a steroid hormone that initiates larval molting and metamorphosis. Here, we test this by examining the consequences of null mutations in the Ptth gene for Drosophila development. Loss of Ptth causes several developmental defects, including a delay in developmental timing, increase in critical weight, loss of coordination between body and imaginal disc growth, and reduced adult survival in suboptimal environmental conditions such as nutritional deprivation or high population density. These defects are caused by a decrease in ecdysone production associated with altered transcription of ecdysone biosynthetic genes. Therefore, the PTTH signal contributes to coordination between environmental cues and the developmental program to ensure individual fitness and survival.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/219360
url http://hdl.handle.net/10261/219360
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1242/dev.159699
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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