High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study
[Background & Aims] Liver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little is known about the prevalence of liver fibrosis in the general population. The aim of the study was to investigate the prevalence of liver fibrosis in the general adult population wi...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/176336 |
| Acceso en línea: | http://hdl.handle.net/10261/176336 |
| Access Level: | acceso abierto |
| Palabra clave: | NAFLD Liver fibrosis Cirrhosis Transient Elastography |
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oai:digital.csic.es:10261/176336 |
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ES |
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España |
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| dc.title.none.fl_str_mv |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study |
| title |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study |
| spellingShingle |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study Caballería, Llorenç NAFLD Liver fibrosis Cirrhosis Transient Elastography |
| title_short |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study |
| title_full |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study |
| title_fullStr |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study |
| title_full_unstemmed |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study |
| title_sort |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based study |
| dc.creator.none.fl_str_mv |
Caballería, Llorenç Pera, Guillem Arteaga, Ingrid Rodríguez, Lluis Alumà, Alba Morillas, Rosa María Ossa, Napoleón de la Díaz, Alba Expósito, Carmen Miranda, Dolores Sánchez, Carmen Prats, Rosa María Urquizu, Marta Salgado, Angels Alemany, Magda Martínez, Alba Majeed, Irfan Fabrellas, Núria Graupera, Isabel Planas, Ramón Ojanguren, Isabel Serra, Miquel Torán. Pere Caballería, Juan Ginès, Pere |
| author |
Caballería, Llorenç |
| author_facet |
Caballería, Llorenç Pera, Guillem Arteaga, Ingrid Rodríguez, Lluis Alumà, Alba Morillas, Rosa María Ossa, Napoleón de la Díaz, Alba Expósito, Carmen Miranda, Dolores Sánchez, Carmen Prats, Rosa María Urquizu, Marta Salgado, Angels Alemany, Magda Martínez, Alba Majeed, Irfan Fabrellas, Núria Graupera, Isabel Planas, Ramón Ojanguren, Isabel Serra, Miquel Torán. Pere Caballería, Juan Ginès, Pere |
| author_role |
author |
| author2 |
Pera, Guillem Arteaga, Ingrid Rodríguez, Lluis Alumà, Alba Morillas, Rosa María Ossa, Napoleón de la Díaz, Alba Expósito, Carmen Miranda, Dolores Sánchez, Carmen Prats, Rosa María Urquizu, Marta Salgado, Angels Alemany, Magda Martínez, Alba Majeed, Irfan Fabrellas, Núria Graupera, Isabel Planas, Ramón Ojanguren, Isabel Serra, Miquel Torán. Pere Caballería, Juan Ginès, Pere |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III Ministerio de Economía y Competitividad (España) European Commission Generalitat de Catalunya Institución Catalana de Investigación y Estudios Avanzados Martínez, Alba [0000-0003-0667-1609] Torán. Pere [0000-0002-9865-7427] Ginès, Pere [0000-0003-4657-4504] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
NAFLD Liver fibrosis Cirrhosis Transient Elastography |
| topic |
NAFLD Liver fibrosis Cirrhosis Transient Elastography |
| description |
[Background & Aims] Liver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little is known about the prevalence of liver fibrosis in the general population. The aim of the study was to investigate the prevalence of liver fibrosis in the general adult population with unknown liver disease. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2019 2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10261/176336 |
| url |
http://hdl.handle.net/10261/176336 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
https://doi.org/10.1016/j.cgh.2017.12.048 Sí |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| collection |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869403639689248768 |
| spelling |
High prevalence of liver fibrosis among european adults with unknown liver disease: a population-based studyCaballería, LlorençPera, GuillemArteaga, IngridRodríguez, LluisAlumà, AlbaMorillas, Rosa MaríaOssa, Napoleón de laDíaz, AlbaExpósito, CarmenMiranda, DoloresSánchez, CarmenPrats, Rosa MaríaUrquizu, MartaSalgado, AngelsAlemany, MagdaMartínez, AlbaMajeed, IrfanFabrellas, NúriaGraupera, IsabelPlanas, RamónOjanguren, IsabelSerra, MiquelTorán. PereCaballería, JuanGinès, PereNAFLDLiver fibrosisCirrhosisTransient Elastography[Background & Aims] Liver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little is known about the prevalence of liver fibrosis in the general population. The aim of the study was to investigate the prevalence of liver fibrosis in the general adult population with unknown liver disease.[Methods] This was a population-based, cross-sectional study performed in the Barcelona metropolitan area. Subjects aged 18 to 75 years old were identified randomly from citizens included in the primary health care registry. Of 4866 subjects invited, 3076 participated (63.2%). Liver fibrosis was estimated by measuring liver stiffness (LS) with transient elastography (TE). Liver histology was assessed in 92 subjects with increased LS.[Results] Prevalence estimates of increased LS (≥6.8, ≥8.0, and ≥9.0 kPa) were 9.0%, 5.8%, and 3.6%, respectively. The etiology of liver disease was mainly nonalcoholic fatty liver disease (NAFLD), followed by alcohol risk consumption (consumption of ≥21 standard drinking units/wk in men and ≥14 standard drinking units/wk in women). Factors independently associated with increased LS were male sex, abdominal obesity, type 2 diabetes, serum glucose, high-density lipoprotein, and triglyceride levels. Subjects without risk factors for NAFLD or without alcohol risk consumption had a very low prevalence of increased LS. The best cut-off value of LS for significant liver fibrosis (F2–F4) was 9.2 kPa, with high sensitivity and specificity. TE was more accurate than alanine aminotransferase, NAFLD fibrosis score, or Fibrosis 4. An algorithm for screening for liver fibrosis using TE in the community setting is proposed.[Conclusions] These findings show a high prevalence of silent liver disease with advanced fibrosis mainly related to NAFLD in adult European subjects without known liver disease. An LS value less than 9.2 kPa predicts the absence of significant liver fibrosis with high accuracy and could be used for screening purposes.The project received a research grant from the Carlos III Institute of Health, Ministry of Economy and Competitiveness (Spain), awarded on the 2011 call under the Health Strategy Action 2013–2016, within the National Research Program oriented to Societal Challenges, within the Technical, Scientific and Innovation Research National Plan 2013–2016, with reference PI11/0267, co-funded by European Union European Regional Development Fund funds. Also supported by grants from Fondo de Investigación Sanitaria Instituto de Salud Carlos III-Subdirección General de Evaluación and the European Regional Development Fund Fondo Europeo de Desarrollo Regional (PI16/ 00043), the Agencia de Gestió d’Ajuts Universitarisi de Recerca, and the European Horizon 20/20 program, H20/20-SC1-2016-RTD, and an Institució Catalana de Recerca I Estudis Avançats Academy Award (P.G.).Peer reviewedElsevierInstituto de Salud Carlos IIIMinisterio de Economía y Competitividad (España)European CommissionGeneralitat de CatalunyaInstitución Catalana de Investigación y Estudios AvanzadosMartínez, Alba [0000-0003-0667-1609]Torán. Pere [0000-0002-9865-7427]Ginès, Pere [0000-0003-4657-4504]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/176336reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.cgh.2017.12.048Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1763362026-05-22T06:33:51Z |
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15,812429 |