Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administrati...

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Detalles Bibliográficos
Autores: Rodríguez-Pérez, María Dolores, López-Villodres, Juan Antonio, Arrebola, María Monsalud, Martín-Aurioles, Esther, Fernández-Prior, África, Bermúdez-Oria, Alejandra, Ríos, María Carmen, De La Cruz, José Pedro, González-Correa, José Antonio
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18499
Acceso en línea:http://hdl.handle.net/20.500.12105/18499
Access Level:acceso abierto
Palabra clave:Hydroxytyrosol
Diabetes
Nephropathy
Virgin olive oil
Diabetes mellitus
Creatinine
Oxidative stress
Proteinuria
Thromboxane
Eicosanoids
Nefropatías diabéticas
Aceite de oliva
Creatinina
Estrés oxidativo
Tromboxanos
Eicosanoides
Rats
Animals
Streptozocin
Diabetes Mellitus, Experimental
Antioxidants
Diabetes Mellitus, Type 1
Oxidative Stress
Kidney
Administration, Oral
Models, Theoretical
Thromboxanes
Descripción
Sumario:The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.

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