Collagen Type I Biomaterials as Scaffolds for Bone Tissue Engineering
Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/18258 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/18258 |
| Access Level: | acceso abierto |
| Palabra clave: | Collagen Bone tissue engineering Scaffolds Growth factors Peptides Colágeno Huesos Ingeniería de tejidos Andamios del tejido Péptidos y proteínas de señalización intercelular Péptidos Animals Tissue Engineering Collagen Type I Autografts Bone Regeneration Biocompatible Materials Hydrogels Extracellular Matrix |
| Sumario: | Collagen type I is the main organic constituent of the bone extracellular matrix and has been used for decades as scaffolding material in bone tissue engineering approaches when autografts are not feasible. Polymeric collagen can be easily isolated from various animal sources and can be processed in a great number of ways to manufacture biomaterials in the form of sponges, particles, or hydrogels, among others, for different applications. Despite its great biocompatibility and osteoconductivity, collagen type I also has some drawbacks, such as its high biodegradability, low mechanical strength, and lack of osteoinductive activity. Therefore, many attempts have been made to improve the collagen type I-based implants for bone tissue engineering. This review aims to summarize the current status of collagen type I as a biomaterial for bone tissue engineering, as well as to highlight some of the main efforts that have been made recently towards designing and producing collagen implants to improve bone regeneration. |
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