Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients

Immunological tests; Bronchiectasis

Detalles Bibliográficos
Autores: Amati, Francesco, Vigone, Barbara, Oriano, Martina, Sotgiu, Giovanni, Polverino, Eva, Aliberti, Stefano, Gramegna, Andrea
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/8004
Acceso en línea:https://hdl.handle.net/11351/8004
Access Level:acceso abierto
Palabra clave:Bronquièctasi
Immunodeficiència
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
DISEASES::Immune System Diseases::Immunologic Deficiency Syndromes::Common Variable Immunodeficiency
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
ENFERMEDADES::enfermedades del sistema inmune::síndromes de inmunodeficiencia::inmunodeficiencia variable común
Otros calificadores::Otros calificadores::/diagnóstico
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oai_identifier_str oai:recercat.cat:11351/8004
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
title Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
spellingShingle Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
Amati, Francesco
Bronquièctasi
Immunodeficiència
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
DISEASES::Immune System Diseases::Immunologic Deficiency Syndromes::Common Variable Immunodeficiency
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
ENFERMEDADES::enfermedades del sistema inmune::síndromes de inmunodeficiencia::inmunodeficiencia variable común
Otros calificadores::Otros calificadores::/diagnóstico
title_short Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
title_full Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
title_fullStr Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
title_full_unstemmed Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
title_sort Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patients
dc.creator.none.fl_str_mv Amati, Francesco
Vigone, Barbara
Oriano, Martina
Sotgiu, Giovanni
Polverino, Eva
Aliberti, Stefano
Gramegna, Andrea
author Amati, Francesco
author_facet Amati, Francesco
Vigone, Barbara
Oriano, Martina
Sotgiu, Giovanni
Polverino, Eva
Aliberti, Stefano
Gramegna, Andrea
author_role author
author2 Vigone, Barbara
Oriano, Martina
Sotgiu, Giovanni
Polverino, Eva
Aliberti, Stefano
Gramegna, Andrea
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Aliberti S, Amati F] Dept of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. IRCCS Humanitas Research Hospital, Respiratory Unit, Rozzano, Italy. [Gramegna A, Oriano M] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy. Dept of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. [Vigone B] Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. [Sotgiu G] Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. [Polverino E] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Bronquièctasi
Immunodeficiència
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
DISEASES::Immune System Diseases::Immunologic Deficiency Syndromes::Common Variable Immunodeficiency
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
ENFERMEDADES::enfermedades del sistema inmune::síndromes de inmunodeficiencia::inmunodeficiencia variable común
Otros calificadores::Otros calificadores::/diagnóstico
topic Bronquièctasi
Immunodeficiència
DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Bronchiectasis
DISEASES::Immune System Diseases::Immunologic Deficiency Syndromes::Common Variable Immunodeficiency
Other subheadings::Other subheadings::/diagnosis
ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasia
ENFERMEDADES::enfermedades del sistema inmune::síndromes de inmunodeficiencia::inmunodeficiencia variable común
Otros calificadores::Otros calificadores::/diagnóstico
description Immunological tests; Bronchiectasis
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8004
url https://hdl.handle.net/11351/8004
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv ERJ Open Research;8(1)
http://dx.doi.org/10.1183/23120541.00388-2021
dc.rights.none.fl_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Respiratory Society
publisher.none.fl_str_mv European Respiratory Society
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403628188467200
spelling Comparison of different sets of immunological tests to identify treatable immunodeficiencies in adult bronchiectasis patientsAmati, FrancescoVigone, BarbaraOriano, MartinaSotgiu, GiovanniPolverino, EvaAliberti, StefanoGramegna, AndreaBronquièctasiImmunodeficiènciaDISEASES::Respiratory Tract Diseases::Bronchial Diseases::BronchiectasisDISEASES::Immune System Diseases::Immunologic Deficiency Syndromes::Common Variable ImmunodeficiencyOther subheadings::Other subheadings::/diagnosisENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::bronquiectasiaENFERMEDADES::enfermedades del sistema inmune::síndromes de inmunodeficiencia::inmunodeficiencia variable comúnOtros calificadores::Otros calificadores::/diagnósticoImmunological tests; BronchiectasisPruebas inmunologicas; BronquiectasiasProves immunològiques; BronquiectasiesBackground The reported prevalence of immunodeficiencies in bronchiectasis patients is variable depending on the frequency and extent of immunological tests performed. European Respiratory Society guidelines recommend a minimum bundle of tests. Broadening the spectrum of immunological tests could increase the number of patients diagnosed with an immunodeficiency and those who could receive specific therapy. The primary objective of the present study was to assess the performance of different sets of immunological tests in diagnosing any, primary, secondary or treatable immunodeficiencies in adults with bronchiectasis. Methods An observational, cross-sectional study was conducted at the Bronchiectasis Program of the Policlinico University Hospital in Milan, Italy, from September 2016 to June 2019. Adult outpatients with a clinical and radiological diagnosis of bronchiectasis underwent the same immunological screening during the first visit when clinically stable consisting of: complete blood count; immunoglobulin (Ig) subclass tests for IgA, IgG, IgM and IgG; total IgE; lymphocyte subsets; and HIV antibodies. The primary endpoint was the prevalence of patients with any immunodeficiencies using five different sets of immunological tests. Results A total of 401 bronchiectasis patients underwent the immunological screening. A significantly different prevalence of bronchiectasis patients diagnosed with any, primary or secondary immunodeficiencies was found across different bundles. 44.6% of bronchiectasis patients had a diagnosis of immunodeficiency when IgG subclasses and lymphocyte subsets were added to the minimum bundle suggested by the guidelines. Conclusion A four-fold increase in the diagnosis of immunodeficiencies can be found in adults with bronchiectasis when IgG subclasses and lymphocyte subsets are added to the bundle of tests recommended by guidelines.European Respiratory SocietyInstitut Català de la Salut[Aliberti S, Amati F] Dept of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. IRCCS Humanitas Research Hospital, Respiratory Unit, Rozzano, Italy. [Gramegna A, Oriano M] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy. Dept of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy. [Vigone B] Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy. [Sotgiu G] Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy. [Polverino E] Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8004Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésERJ Open Research;8(1)http://dx.doi.org/10.1183/23120541.00388-2021Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/80042026-05-29T05:05:01Z
score 15,812429

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