Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer

The aim was to investigate the concentrations of some per- and polyfluoroalkyl substances (PFAS) in patients with pancreatic cancer from New York, and to compare them with a group of controls from the general population of the United States. We selected 50 cases of pancreatic cancer from donors to t...

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Authors: Long, Sara, Porta, Miquel|||0000-0003-1684-7428, Yang, Jeffrey, Jing, Xiaohong, Gasull, Magda|||0000-0003-4546-3650, Burgos, Gabriela, Simeone, Diane, Trasande, Leonardo|||0000-0002-1928-597X
Format: article
Publication Date:2024
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:302356
Online Access:https://ddd.uab.cat/record/302356
https://dx.doi.org/urn:doi:10.1007/s12403-024-00661-5
Access Level:Open access
Keyword:Pancreatic cancer
Per-and polyfuoroalkyl substances (PFAS)
Perfuorohexane sulfonic acid (PFHxS)
Perfuoroundecanoic acid (PFUnDA)
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spelling Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic CancerA Case-Control Study in New YorkLong, SaraPorta, Miquel|||0000-0003-1684-7428Yang, JeffreyJing, XiaohongGasull, Magda|||0000-0003-4546-3650Burgos, GabrielaSimeone, DianeTrasande, Leonardo|||0000-0002-1928-597XPancreatic cancerPer-and polyfuoroalkyl substances (PFAS)Perfuorohexane sulfonic acid (PFHxS)Perfuoroundecanoic acid (PFUnDA)The aim was to investigate the concentrations of some per- and polyfluoroalkyl substances (PFAS) in patients with pancreatic cancer from New York, and to compare them with a group of controls from the general population of the United States. We selected 50 cases of pancreatic cancer from donors to the New York University Pancreatic Biorepository. Controls were selected from the 2017-18 National Health and Examination Survey sample (n = 167), matched to cases on age, sex, and race and ethnicity. Six PFAS were analyzed in serum samples using high performance liquid chromatography in conjunction with mass spectrometry. PFAS concentrations were categorized into tertiles to explore non-linear associations, and odds ratios (OR) were estimated using conditional logistic regression, adjusting by BMI. Most PFAS were not associated with pancreatic cancer risk. Serum perfluorohexane sulfonic acid (PFHxS) was associated with a decreased risk (OR for upper tertile = 0.24, 95% CI: 0.09, 0.67). In contrast, participants with the highest tertile of perfluoroundecanoic acid (PFUnDA) had a higher risk (OR = 2.60, 95% CI: 1.11, 6.09). Adjusting for BMI did not materially change the results. Study limitations include: in pancreatic cancer patients, blood used to measure PFAS was collected around the time of diagnosis; cases and controls could not be sampled from the same geographic location; slightly different laboratory methods were used to analyze PFAS in cases and controls. Most PFAS studied were not significantly associated with pancreatic cancer, except for PFHxS and PFUnDA, which exhibited opposite trends. Findings and limitations of the present study warrant further investigation with improved study designs and data on complex PFAS mixtures.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/302356https://dx.doi.org/urn:doi:10.1007/s12403-024-00661-5reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3023562026-06-06T12:50:31Z
dc.title.none.fl_str_mv Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
A Case-Control Study in New York
title Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
spellingShingle Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
Long, Sara
Pancreatic cancer
Per-and polyfuoroalkyl substances (PFAS)
Perfuorohexane sulfonic acid (PFHxS)
Perfuoroundecanoic acid (PFUnDA)
title_short Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
title_full Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
title_fullStr Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
title_full_unstemmed Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
title_sort Concentrations of Per-and Polyfluoroalkyl Substances (PFAS) and Pancreatic Cancer
dc.creator.none.fl_str_mv Long, Sara
Porta, Miquel|||0000-0003-1684-7428
Yang, Jeffrey
Jing, Xiaohong
Gasull, Magda|||0000-0003-4546-3650
Burgos, Gabriela
Simeone, Diane
Trasande, Leonardo|||0000-0002-1928-597X
author Long, Sara
author_facet Long, Sara
Porta, Miquel|||0000-0003-1684-7428
Yang, Jeffrey
Jing, Xiaohong
Gasull, Magda|||0000-0003-4546-3650
Burgos, Gabriela
Simeone, Diane
Trasande, Leonardo|||0000-0002-1928-597X
author_role author
author2 Porta, Miquel|||0000-0003-1684-7428
Yang, Jeffrey
Jing, Xiaohong
Gasull, Magda|||0000-0003-4546-3650
Burgos, Gabriela
Simeone, Diane
Trasande, Leonardo|||0000-0002-1928-597X
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Pancreatic cancer
Per-and polyfuoroalkyl substances (PFAS)
Perfuorohexane sulfonic acid (PFHxS)
Perfuoroundecanoic acid (PFUnDA)
topic Pancreatic cancer
Per-and polyfuoroalkyl substances (PFAS)
Perfuorohexane sulfonic acid (PFHxS)
Perfuoroundecanoic acid (PFUnDA)
description The aim was to investigate the concentrations of some per- and polyfluoroalkyl substances (PFAS) in patients with pancreatic cancer from New York, and to compare them with a group of controls from the general population of the United States. We selected 50 cases of pancreatic cancer from donors to the New York University Pancreatic Biorepository. Controls were selected from the 2017-18 National Health and Examination Survey sample (n = 167), matched to cases on age, sex, and race and ethnicity. Six PFAS were analyzed in serum samples using high performance liquid chromatography in conjunction with mass spectrometry. PFAS concentrations were categorized into tertiles to explore non-linear associations, and odds ratios (OR) were estimated using conditional logistic regression, adjusting by BMI. Most PFAS were not associated with pancreatic cancer risk. Serum perfluorohexane sulfonic acid (PFHxS) was associated with a decreased risk (OR for upper tertile = 0.24, 95% CI: 0.09, 0.67). In contrast, participants with the highest tertile of perfluoroundecanoic acid (PFUnDA) had a higher risk (OR = 2.60, 95% CI: 1.11, 6.09). Adjusting for BMI did not materially change the results. Study limitations include: in pancreatic cancer patients, blood used to measure PFAS was collected around the time of diagnosis; cases and controls could not be sampled from the same geographic location; slightly different laboratory methods were used to analyze PFAS in cases and controls. Most PFAS studied were not significantly associated with pancreatic cancer, except for PFHxS and PFUnDA, which exhibited opposite trends. Findings and limitations of the present study warrant further investigation with improved study designs and data on complex PFAS mixtures.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/302356
https://dx.doi.org/urn:doi:10.1007/s12403-024-00661-5
url https://ddd.uab.cat/record/302356
https://dx.doi.org/urn:doi:10.1007/s12403-024-00661-5
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
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