Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group

BACKGROUND AND OBJECTIVE: Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and...

Descripción completa

Detalles Bibliográficos
Autores: Mingot-Castellano, M. Eva, Álvarez Román, M. Teresa, Fernández Fuertes, Luis Fernando, González-López, Tomás José, Guinea de Castro, José María, Jarque, Isidro, López-Fernández, M. Fernanda, Lozano, Maria Luisa, Sanchez Gonzalez, Blanca, Valcárcel, David, González Porras, José Ramón
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/42732
Acceso en línea:http://hdl.handle.net/10230/42732
http://dx.doi.org/10.1155/2019/4621416
Access Level:acceso abierto
Palabra clave:Trombocitopènia
Hematologia
id ES_125e8ed3df2a529629dfd7c69f69c4c8
oai_identifier_str oai:repositori.upf.edu:10230/42732
network_acronym_str ES
network_name_str España
repository_id_str
spelling Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert groupMingot-Castellano, M. EvaÁlvarez Román, M. TeresaFernández Fuertes, Luis FernandoGonzález-López, Tomás JoséGuinea de Castro, José MaríaJarque, IsidroLópez-Fernández, M. FernandaLozano, Maria LuisaSanchez Gonzalez, BlancaValcárcel, DavidGonzález Porras, José RamónTrombocitopèniaHematologiaBACKGROUND AND OBJECTIVE: Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and management of adult patients with ITP. MATERIALS AND METHODS: A two-round Delphi method was carried out by sending to 129 experts a 90-item questionnaire developed by 11 specialists, with a 4-point Likert scale ("never," "sometimes," "frequently," and "always") for the assessment of responses. RESULTS: Forty out of the 129 experts participated in the survey (participation rate 30.2%) and 39 completed the questionnaire (response rate 97.5%). Salient consensus points included the following: the need to indicate workup studies from a sustained platelet count < 100 x 109/L in the absence of a clear etiology; bone marrow aspiration in elderly patients with suspected ITP; beginning treatment in asymptomatic patients with a platelet count < 20 x 109/L; not exceeding 6-7 weeks of corticosteroid therapy; switching from corticosteroids to one thrombopoietin receptor agonist (TRA); switching to other TRA or other options as combinations of them with immunosuppressive drugs in case of failure; how to reduce tapering TRA; treating patients with symptomatic persistent ITP and platelet count > 20 x 109/L; and considering mucosal or severe bleeding as a basic criterion for hospital admission. CONCLUSIONS: The present consensus document provides a reference framework for the management of patients with ITP in clinical practice.Hindawi201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42732http://dx.doi.org/10.1155/2019/4621416reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCopyright © 2019 M. Eva Mingot-Castellano et al. Tis is an open access article distributed under the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/ which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/427322026-06-12T07:21:37Z
dc.title.none.fl_str_mv Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
title Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
spellingShingle Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
Mingot-Castellano, M. Eva
Trombocitopènia
Hematologia
title_short Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
title_full Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
title_fullStr Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
title_full_unstemmed Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
title_sort Management of adult patients with primary immune thrombocytopenia (ITP) in clinical practice: a consensus approach of the Spanish ITP expert group
dc.creator.none.fl_str_mv Mingot-Castellano, M. Eva
Álvarez Román, M. Teresa
Fernández Fuertes, Luis Fernando
González-López, Tomás José
Guinea de Castro, José María
Jarque, Isidro
López-Fernández, M. Fernanda
Lozano, Maria Luisa
Sanchez Gonzalez, Blanca
Valcárcel, David
González Porras, José Ramón
author Mingot-Castellano, M. Eva
author_facet Mingot-Castellano, M. Eva
Álvarez Román, M. Teresa
Fernández Fuertes, Luis Fernando
González-López, Tomás José
Guinea de Castro, José María
Jarque, Isidro
López-Fernández, M. Fernanda
Lozano, Maria Luisa
Sanchez Gonzalez, Blanca
Valcárcel, David
González Porras, José Ramón
author_role author
author2 Álvarez Román, M. Teresa
Fernández Fuertes, Luis Fernando
González-López, Tomás José
Guinea de Castro, José María
Jarque, Isidro
López-Fernández, M. Fernanda
Lozano, Maria Luisa
Sanchez Gonzalez, Blanca
Valcárcel, David
González Porras, José Ramón
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trombocitopènia
Hematologia
topic Trombocitopènia
Hematologia
description BACKGROUND AND OBJECTIVE: Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and management of adult patients with ITP. MATERIALS AND METHODS: A two-round Delphi method was carried out by sending to 129 experts a 90-item questionnaire developed by 11 specialists, with a 4-point Likert scale ("never," "sometimes," "frequently," and "always") for the assessment of responses. RESULTS: Forty out of the 129 experts participated in the survey (participation rate 30.2%) and 39 completed the questionnaire (response rate 97.5%). Salient consensus points included the following: the need to indicate workup studies from a sustained platelet count < 100 x 109/L in the absence of a clear etiology; bone marrow aspiration in elderly patients with suspected ITP; beginning treatment in asymptomatic patients with a platelet count < 20 x 109/L; not exceeding 6-7 weeks of corticosteroid therapy; switching from corticosteroids to one thrombopoietin receptor agonist (TRA); switching to other TRA or other options as combinations of them with immunosuppressive drugs in case of failure; how to reduce tapering TRA; treating patients with symptomatic persistent ITP and platelet count > 20 x 109/L; and considering mucosal or severe bleeding as a basic criterion for hospital admission. CONCLUSIONS: The present consensus document provides a reference framework for the management of patients with ITP in clinical practice.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/42732
http://dx.doi.org/10.1155/2019/4621416
url http://hdl.handle.net/10230/42732
http://dx.doi.org/10.1155/2019/4621416
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403615102238720
score 15,812429

Similares en LA Referencia