Noise-induced bistability in the fate of cancer phenotypic quasispecies

Tumor cell populations are highly heterogeneous. Such heterogeneity, both at genotypic and phenotypic levels, is a key feature during tumorigenesis. How to investigate the impact of this heterogeneity in the dynamics of tumors cells becomes an important issue. Here we explore a stochastic model desc...

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Autores: Sardanyés, Josep|||0000-0001-7225-5158, Alarcón Cor, Tomás|||0000-0002-8566-3676
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253421
Acceso en línea:https://ddd.uab.cat/record/253421
https://dx.doi.org/urn:doi:10.1038/s41598-018-19552-2
Access Level:acceso abierto
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spelling Noise-induced bistability in the fate of cancer phenotypic quasispeciesa bit-strings approachSardanyés, Josep|||0000-0001-7225-5158Alarcón Cor, Tomás|||0000-0002-8566-3676Tumor cell populations are highly heterogeneous. Such heterogeneity, both at genotypic and phenotypic levels, is a key feature during tumorigenesis. How to investigate the impact of this heterogeneity in the dynamics of tumors cells becomes an important issue. Here we explore a stochastic model describing the competition dynamics between a pool of heterogeneous cancer cells with distinct phenotypes and healthy cells. This model is used to explore the role of demographic fluctuations on the transitions involving tumor clearance. Our results show that for large population sizes, when demographic fluctuations are negligible, there exists a sharp transition responsible for tumor cells extinction at increasing tumor cells' mutation rates. This result is consistent with a mean field model developed for the same system. The mean field model reveals only monostability scenarios, in which either the dominance of the tumor cells or the dominance of the healthy cells is found. Interestingly, the stochastic model shows that for small population sizes the monostability behavior disappears, involving the presence of noise-induced bistability. The impact of the initial populations of cells in the fate of the cell populations is investigated, as well as the transient times towards the healthy and the cancer states. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253421https://dx.doi.org/urn:doi:10.1038/s41598-018-19552-2reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 MDM-2014-0445Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1307Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MTM2015-71509-C2-1-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2534212026-06-06T12:50:31Z
dc.title.none.fl_str_mv Noise-induced bistability in the fate of cancer phenotypic quasispecies
a bit-strings approach
title Noise-induced bistability in the fate of cancer phenotypic quasispecies
spellingShingle Noise-induced bistability in the fate of cancer phenotypic quasispecies
Sardanyés, Josep|||0000-0001-7225-5158
title_short Noise-induced bistability in the fate of cancer phenotypic quasispecies
title_full Noise-induced bistability in the fate of cancer phenotypic quasispecies
title_fullStr Noise-induced bistability in the fate of cancer phenotypic quasispecies
title_full_unstemmed Noise-induced bistability in the fate of cancer phenotypic quasispecies
title_sort Noise-induced bistability in the fate of cancer phenotypic quasispecies
dc.creator.none.fl_str_mv Sardanyés, Josep|||0000-0001-7225-5158
Alarcón Cor, Tomás|||0000-0002-8566-3676
author Sardanyés, Josep|||0000-0001-7225-5158
author_facet Sardanyés, Josep|||0000-0001-7225-5158
Alarcón Cor, Tomás|||0000-0002-8566-3676
author_role author
author2 Alarcón Cor, Tomás|||0000-0002-8566-3676
author2_role author
description Tumor cell populations are highly heterogeneous. Such heterogeneity, both at genotypic and phenotypic levels, is a key feature during tumorigenesis. How to investigate the impact of this heterogeneity in the dynamics of tumors cells becomes an important issue. Here we explore a stochastic model describing the competition dynamics between a pool of heterogeneous cancer cells with distinct phenotypes and healthy cells. This model is used to explore the role of demographic fluctuations on the transitions involving tumor clearance. Our results show that for large population sizes, when demographic fluctuations are negligible, there exists a sharp transition responsible for tumor cells extinction at increasing tumor cells' mutation rates. This result is consistent with a mean field model developed for the same system. The mean field model reveals only monostability scenarios, in which either the dominance of the tumor cells or the dominance of the healthy cells is found. Interestingly, the stochastic model shows that for small population sizes the monostability behavior disappears, involving the presence of noise-induced bistability. The impact of the initial populations of cells in the fate of the cell populations is investigated, as well as the transient times towards the healthy and the cancer states.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253421
https://dx.doi.org/urn:doi:10.1038/s41598-018-19552-2
url https://ddd.uab.cat/record/253421
https://dx.doi.org/urn:doi:10.1038/s41598-018-19552-2
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MDM-2014-0445
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-1307
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 MTM2015-71509-C2-1-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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