Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults

Cognitive decline is one of the most important consequences of aging and pharmacological therapies had been largely unsuccessful. Other strategies include the use of functional foods to reduce the burden of cognitive decline. The MFGM is an important source of polar lipids and glycoproteins that dec...

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Autores: V. Calvo, María, Loria Kohen , Viviana, Díaz Mardomingo, María del Carmen, García Herranz, Sara, Baliyan, Shishir, Carneiro , João Tomé, Colmenarejo, Gonzalo, Visioli, Francesco, Venero Núñez, César, Fontecha, Javier
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universidad Nacional de Educación a Distancia
Repositorio:e-spacio. Repositorio Institucional de la UNED
Idioma:inglés
OAI Identifier:oai:e-spacio.uned.es:20.500.14468/25504
Acesso em linha:https://hdl.handle.net/20.500.14468/25504
Access Level:acceso abierto
Palavra-chave:32 Ciencias Médicas ::3206 Ciencias de la Nutrición
membrana del glóbulo de grasa de la leche (MFGM)
Deterioro cognitivo
Memoria
Envejecimiento
Fosfolípidos
Ensayo controlado aleatorio
milk fat globule membrane (MFGM)
Cognitive decline Memory Aging
Phospholipids
Randomized controlled trial
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spelling Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adultsLa leche enriquecida con membranas de glóbulos de grasa de la leche mejora la memoria episódica: un ensayo aleatorizado, paralelo, doble ciego y controlado con placebo en adultos mayoresV. Calvo, MaríaLoria Kohen , VivianaDíaz Mardomingo, María del CarmenGarcía Herranz, SaraBaliyan, ShishirCarneiro , João ToméColmenarejo, GonzaloVisioli, FrancescoVenero Núñez, CésarFontecha, Javier32 Ciencias Médicas ::3206 Ciencias de la Nutriciónmembrana del glóbulo de grasa de la leche (MFGM)Deterioro cognitivoMemoriaEnvejecimientoFosfolípidosEnsayo controlado aleatoriomilk fat globule membrane (MFGM)Cognitive decline Memory AgingPhospholipidsRandomized controlled trialCognitive decline is one of the most important consequences of aging and pharmacological therapies had been largely unsuccessful. Other strategies include the use of functional foods to reduce the burden of cognitive decline. The MFGM is an important source of polar lipids and glycoproteins that decline in the aging brain. We have developed a milk drink fortified with MFGM (MFGM-M) as a dietary supplement and studied it in a randomized clinical pilot study. Forty-four > 65-year-old healthy or mildly cognitively impaired subjects received MFGM-M or control milk (CM) for 14 weeks, during which they underwent a battery of cognitive tests. Lipidomic analyzes were also performed. The female participants showed improvement in episodic memory, the ability to recall events in our lives. It is conceivable that any intervention should be started before clinical symptoms manifest, as a preventive measure against cognitive decline. Future long-term studies may shed further light on this pointEl deterioro cognitivo es una de las consecuencias más importantes del envejecimiento y las terapias farmacológicas han sido en gran medida infructuosas. Otras estrategias incluyen el uso de alimentos funcionales para reducir la carga del deterioro cognitivo. El MFGM es una fuente importante de lípidos polares y glicoproteínas que disminuyen en el cerebro envejecido. Hemos desarrollado una bebida láctea fortificada con MFGM (MFGM-M) como suplemento dietético y la hemos estudiado en un estudio piloto clínico aleatorizado. Cuarenta y cuatro sujetos > 65 años sanos o con deterioro cognitivo leve recibieron MFGM-M o leche de control (CM) durante 14 semanas, durante las cuales se sometieron a una batería de pruebas cognitivas. También se realizaron análisis lipidómicos. Las participantes femeninas mostraron una mejora en la memoria episódica, la capacidad de recordar eventos en nuestras vidas. Es concebible que cualquier intervención deba iniciarse antes de que se manifiesten los síntomas clínicos, como medida preventiva contra el deterioro cognitivo. Futuros estudios a largo plazo pueden arrojar más luz sobre este punto.Elsevierhttps://orcid.org/0000-0002-6785-7661https://orcid.org/0000-0001-8686-3306https://orcid.org/0000-0002-3597-9234https://orcid.org/0000-0002-8249-4547https://orcid.org/0000-0001-5719-2304e-Spacio UNED20252025-01-2420232023-12-0120232023-12-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/25504reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/255042026-06-06T12:38:31Z
dc.title.none.fl_str_mv Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
La leche enriquecida con membranas de glóbulos de grasa de la leche mejora la memoria episódica: un ensayo aleatorizado, paralelo, doble ciego y controlado con placebo en adultos mayores
title Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
spellingShingle Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
V. Calvo, María
32 Ciencias Médicas ::3206 Ciencias de la Nutrición
membrana del glóbulo de grasa de la leche (MFGM)
Deterioro cognitivo
Memoria
Envejecimiento
Fosfolípidos
Ensayo controlado aleatorio
milk fat globule membrane (MFGM)
Cognitive decline Memory Aging
Phospholipids
Randomized controlled trial
title_short Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
title_full Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
title_fullStr Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
title_full_unstemmed Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
title_sort Milk fat globule membrane-enriched milk improves episodic memory: A randomized, parallel, double-blind, placebo-controlled trial in older adults
dc.creator.none.fl_str_mv V. Calvo, María
Loria Kohen , Viviana
Díaz Mardomingo, María del Carmen
García Herranz, Sara
Baliyan, Shishir
Carneiro , João Tomé
Colmenarejo, Gonzalo
Visioli, Francesco
Venero Núñez, César
Fontecha, Javier
author V. Calvo, María
author_facet V. Calvo, María
Loria Kohen , Viviana
Díaz Mardomingo, María del Carmen
García Herranz, Sara
Baliyan, Shishir
Carneiro , João Tomé
Colmenarejo, Gonzalo
Visioli, Francesco
Venero Núñez, César
Fontecha, Javier
author_role author
author2 Loria Kohen , Viviana
Díaz Mardomingo, María del Carmen
García Herranz, Sara
Baliyan, Shishir
Carneiro , João Tomé
Colmenarejo, Gonzalo
Visioli, Francesco
Venero Núñez, César
Fontecha, Javier
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv https://orcid.org/0000-0002-6785-7661
https://orcid.org/0000-0001-8686-3306
https://orcid.org/0000-0002-3597-9234
https://orcid.org/0000-0002-8249-4547
https://orcid.org/0000-0001-5719-2304
e-Spacio UNED
dc.subject.none.fl_str_mv 32 Ciencias Médicas ::3206 Ciencias de la Nutrición
membrana del glóbulo de grasa de la leche (MFGM)
Deterioro cognitivo
Memoria
Envejecimiento
Fosfolípidos
Ensayo controlado aleatorio
milk fat globule membrane (MFGM)
Cognitive decline Memory Aging
Phospholipids
Randomized controlled trial
topic 32 Ciencias Médicas ::3206 Ciencias de la Nutrición
membrana del glóbulo de grasa de la leche (MFGM)
Deterioro cognitivo
Memoria
Envejecimiento
Fosfolípidos
Ensayo controlado aleatorio
milk fat globule membrane (MFGM)
Cognitive decline Memory Aging
Phospholipids
Randomized controlled trial
description Cognitive decline is one of the most important consequences of aging and pharmacological therapies had been largely unsuccessful. Other strategies include the use of functional foods to reduce the burden of cognitive decline. The MFGM is an important source of polar lipids and glycoproteins that decline in the aging brain. We have developed a milk drink fortified with MFGM (MFGM-M) as a dietary supplement and studied it in a randomized clinical pilot study. Forty-four > 65-year-old healthy or mildly cognitively impaired subjects received MFGM-M or control milk (CM) for 14 weeks, during which they underwent a battery of cognitive tests. Lipidomic analyzes were also performed. The female participants showed improvement in episodic memory, the ability to recall events in our lives. It is conceivable that any intervention should be started before clinical symptoms manifest, as a preventive measure against cognitive decline. Future long-term studies may shed further light on this point
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-12-01
2023
2023-12-01
2025
2025-01-24
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14468/25504
url https://hdl.handle.net/20.500.14468/25504
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e-spacio. Repositorio Institucional de la UNED
instname:Universidad Nacional de Educación a Distancia
instname_str Universidad Nacional de Educación a Distancia
reponame_str e-spacio. Repositorio Institucional de la UNED
collection e-spacio. Repositorio Institucional de la UNED
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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