Fecal calprotectin in healthy children aged 4–16 years

Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut‑off levels cou...

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Autores: Roca, María, Rodriguez Varela, Ana, Carvajal Roca, Eva, Donat, Ester, Cano, Francisco, Armisen, Ana, Vaya, Maria Jose, Ekoff, Helena, Hervas, David, Rydell, Niclas, Ribes‑Koninckx, Carmen
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/6820
Acceso en línea:https://hdl.handle.net/20.500.12466/6820
Access Level:acceso abierto
Palabra clave:Fecal calprotectin
Children
32 Ciencias Médicas
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spelling Fecal calprotectin in healthy children aged 4–16 yearsRoca, MaríaRodriguez Varela, AnaCarvajal Roca, EvaDonat, EsterCano, FranciscoArmisen, AnaVaya, Maria JoseEkoff, HelenaHervas, DavidRydell, NiclasRibes‑Koninckx, CarmenFecal calprotectinChildren32 Ciencias MédicasReference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut‑off levels could be conclusively recommended. A prospective study was conducted to investigate fCP concentrations of healthy children aged 4–16 years. In 212 healthy children, the median and 95th percentile for fCP were 18.8 mg/kg and 104.5 mg/kg, respectively. We found a statistically significant association between the 95th percentile of fCP concentrations and age (p < 0.001). We propose a nomogram to facilitate the interpretation of fCP results in children aged 4–16 years. Further studies are required to validate the proposed values in clinical practice.20252025-10-2020202020-11-2520202020-11-25journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12466/6820reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/68202026-06-19T08:32:07Z
dc.title.none.fl_str_mv Fecal calprotectin in healthy children aged 4–16 years
title Fecal calprotectin in healthy children aged 4–16 years
spellingShingle Fecal calprotectin in healthy children aged 4–16 years
Roca, María
Fecal calprotectin
Children
32 Ciencias Médicas
title_short Fecal calprotectin in healthy children aged 4–16 years
title_full Fecal calprotectin in healthy children aged 4–16 years
title_fullStr Fecal calprotectin in healthy children aged 4–16 years
title_full_unstemmed Fecal calprotectin in healthy children aged 4–16 years
title_sort Fecal calprotectin in healthy children aged 4–16 years
dc.creator.none.fl_str_mv Roca, María
Rodriguez Varela, Ana
Carvajal Roca, Eva
Donat, Ester
Cano, Francisco
Armisen, Ana
Vaya, Maria Jose
Ekoff, Helena
Hervas, David
Rydell, Niclas
Ribes‑Koninckx, Carmen
author Roca, María
author_facet Roca, María
Rodriguez Varela, Ana
Carvajal Roca, Eva
Donat, Ester
Cano, Francisco
Armisen, Ana
Vaya, Maria Jose
Ekoff, Helena
Hervas, David
Rydell, Niclas
Ribes‑Koninckx, Carmen
author_role author
author2 Rodriguez Varela, Ana
Carvajal Roca, Eva
Donat, Ester
Cano, Francisco
Armisen, Ana
Vaya, Maria Jose
Ekoff, Helena
Hervas, David
Rydell, Niclas
Ribes‑Koninckx, Carmen
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Fecal calprotectin
Children
32 Ciencias Médicas
topic Fecal calprotectin
Children
32 Ciencias Médicas
description Reference values of fecal calprotectin (fCP) have not been convincingly established in children. We aimed to investigate fCP concentrations in a larger population of healthy children aged 4–16 years to analyze more in depth the behavior of fCP in this age range and to determine if cut‑off levels could be conclusively recommended. A prospective study was conducted to investigate fCP concentrations of healthy children aged 4–16 years. In 212 healthy children, the median and 95th percentile for fCP were 18.8 mg/kg and 104.5 mg/kg, respectively. We found a statistically significant association between the 95th percentile of fCP concentrations and age (p < 0.001). We propose a nomogram to facilitate the interpretation of fCP results in children aged 4–16 years. Further studies are required to validate the proposed values in clinical practice.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-11-25
2020
2020-11-25
2025
2025-10-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12466/6820
url https://hdl.handle.net/20.500.12466/6820
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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