Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance

18 p.-2 fig

Detalles Bibliográficos
Autores: Villa, Sara, Bermejo, Rodrigo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/162561
Acceso en línea:http://hdl.handle.net/10261/162561
Access Level:acceso abierto
Palabra clave:Cohesins
DNA replication
Sister chromatid cohesion
Replication forks
DNA replication checkpoint
Cell cycle
Genome integrity
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spelling Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenanceVilla, SaraBermejo, RodrigoCohesinsDNA replicationSister chromatid cohesionReplication forksDNA replication checkpointCell cycleGenome integrity18 p.-2 figProliferating cells need to accurately duplicate and pass their genetic material on to daughter cells. Problems during replication and partition challenge the structural and numerical integrity of chromosomes. Diverse mechanisms, as the DNA replication checkpoint, survey the correct progression of replication and couple it with other cell cycle events to preserve genome integrity. The structural maintenance of chromosomes (SMC) cohesin complex primarily contributes to chromosome duplication by mediating the tethering of newly replicated sister chromatids, thus assisting their equal segregation in mitosis. In addition, cohesin exerts important functions in genome organization, gene expression and DNA repair. These are determined by cohesin’s ability to bring together different DNA segments and, hence, by the fashion and dynamics of its interaction with chromatin. It recently emerged that cohesin contributes to the protection of stalled replication forks through a mechanism requiring its timely mobilization from unreplicated DNA and relocation to nascent strands. This mechanism relies on DNA replication checkpoint-dependent cohesin ubiquitylation and promotes nascent sister chromatid entrapment, likely contributing to preserve stalled replisome-fork architectural integrity. Here we review how cohesin dynamic association to chromatin is controlled through post-translational modifications to dictate its functions during chromosome duplication. We also discuss recent insights on the mechanism that mediates interfacing of replisome components with chromatin-bound cohesin and its contribution to the establishment of sister chromatid cohesion and the protection of stalled replication forks.This work was supported by the Ministry of Economy, Industry and Competitiveness—MINECO (BFU2014-52529-R and BFU2017-87013-R to R.B) and the Spanish Formación del Personal Investigador (FPI) program (to S.V-H.).Peer reviewedSpringer NatureMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/162561reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-52529-Rhttps://doi.org/10.1007/s00294-018-0824-xSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1625612026-05-22T06:33:51Z
dc.title.none.fl_str_mv Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
title Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
spellingShingle Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
Villa, Sara
Cohesins
DNA replication
Sister chromatid cohesion
Replication forks
DNA replication checkpoint
Cell cycle
Genome integrity
title_short Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
title_full Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
title_fullStr Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
title_full_unstemmed Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
title_sort Cohesin dynamic association to chromatin and interfacing with replication forks in genome integrity maintenance
dc.creator.none.fl_str_mv Villa, Sara
Bermejo, Rodrigo
author Villa, Sara
author_facet Villa, Sara
Bermejo, Rodrigo
author_role author
author2 Bermejo, Rodrigo
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cohesins
DNA replication
Sister chromatid cohesion
Replication forks
DNA replication checkpoint
Cell cycle
Genome integrity
topic Cohesins
DNA replication
Sister chromatid cohesion
Replication forks
DNA replication checkpoint
Cell cycle
Genome integrity
description 18 p.-2 fig
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/162561
url http://hdl.handle.net/10261/162561
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2014-52529-R
https://doi.org/10.1007/s00294-018-0824-x
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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