Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.

Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is characterised by small vessel necrotising inflammatory vasculitis. Prior to immunosupressant therapy availability it usually led to a fatal outcome. Current treatment has changed ANCA-associated vasculitis into a condition with...

Full description

Bibliographic Details
Authors: Morales, Enrique, Rúa Figueroa, Iñigo, Callejas Rubio, José Luis, Ávila Bernabéu, Ana, Blanco Alonso, Ricardo, Cid Xutglà, M. Cinta, Manrique Escola, Joaquín, Narváez García, Francisco Javier, Sopeña, Bernardo, Quintana Porras, Luis F., Romero Yuste, Susana, Solans Laqué, Roser
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/220652
Online Access:https://hdl.handle.net/2445/220652
Access Level:Open access
Keyword:Neutròfils
Immunosupressió
Autoanticossos
Inflamació
Vasculitis
Neutrophils
Immunosuppression
Autoantibodies
Inflammation
id ES_11d85ffcddb564ed04a2be3b8ec4a9b2
oai_identifier_str oai:diposit.ub.edu:2445/220652
network_acronym_str ES
network_name_str España
repository_id_str
spelling Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.Morales, EnriqueRúa Figueroa, IñigoCallejas Rubio, José LuisÁvila Bernabéu, AnaBlanco Alonso, RicardoCid Xutglà, M. CintaManrique Escola, JoaquínNarváez García, Francisco JavierSopeña, BernardoQuintana Porras, Luis F.Romero Yuste, SusanaSolans Laqué, RoserNeutròfilsImmunosupressióAutoanticossosInflamacióVasculitisNeutrophilsImmunosuppressionAutoantibodiesInflammationVasculitisAnti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is characterised by small vessel necrotising inflammatory vasculitis. Prior to immunosupressant therapy availability it usually led to a fatal outcome. Current treatment has changed ANCA-associated vasculitis into a condition with a significant response rate, although with a not negligible relapse occurrence and cumulative organ lesions, mostly due to drug-related toxicities. The use of glucocorticoids, cyclophosphamide and other immunosupressants (such as azathioprine, mychophenolate and methotrexate) was optimised in a series of clinical trials that established the treatment of reference. In recent years, a better knowledge of B lymphocyte function and the role of complement inhibition has transformed the course of this disease while minimising treatment-related adverse effects. This multidisciplinary document of recommendations is based on the consensus of three scientific societies (Internal Medicine, Nephrology and Rheumatology) and on the best available evidence on diagnosis, treatment and follow-up of patients with ANCA-associated vasculitis, including some special situations. The aim of this document is to provide updated information and well-grounded clinical recommendations to practising physicians as to how to improve the diagnosis and treatment outcome of our patients.Elsevier España2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/220652Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaEspañolReproducció del document publicat a: https://doi.org/10.1016/j.nefro.2024.07.004Nefrología, 2025, vol. 45, num.1, p. 15-58https://doi.org/10.1016/j.nefro.2024.07.004cc-by-nc-nd (c) Morales, Enrique et al., 2025http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2206522026-05-27T06:46:51Z
dc.title.none.fl_str_mv Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
title Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
spellingShingle Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
Morales, Enrique
Neutròfils
Immunosupressió
Autoanticossos
Inflamació
Vasculitis
Neutrophils
Immunosuppression
Autoantibodies
Inflammation
Vasculitis
title_short Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
title_full Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
title_fullStr Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
title_full_unstemmed Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
title_sort Recomendaciones para el diagnóstico y tratamiento de las vasculitis asociadas a anticuerpos anticitoplasma de neutrófilo.
dc.creator.none.fl_str_mv Morales, Enrique
Rúa Figueroa, Iñigo
Callejas Rubio, José Luis
Ávila Bernabéu, Ana
Blanco Alonso, Ricardo
Cid Xutglà, M. Cinta
Manrique Escola, Joaquín
Narváez García, Francisco Javier
Sopeña, Bernardo
Quintana Porras, Luis F.
Romero Yuste, Susana
Solans Laqué, Roser
author Morales, Enrique
author_facet Morales, Enrique
Rúa Figueroa, Iñigo
Callejas Rubio, José Luis
Ávila Bernabéu, Ana
Blanco Alonso, Ricardo
Cid Xutglà, M. Cinta
Manrique Escola, Joaquín
Narváez García, Francisco Javier
Sopeña, Bernardo
Quintana Porras, Luis F.
Romero Yuste, Susana
Solans Laqué, Roser
author_role author
author2 Rúa Figueroa, Iñigo
Callejas Rubio, José Luis
Ávila Bernabéu, Ana
Blanco Alonso, Ricardo
Cid Xutglà, M. Cinta
Manrique Escola, Joaquín
Narváez García, Francisco Javier
Sopeña, Bernardo
Quintana Porras, Luis F.
Romero Yuste, Susana
Solans Laqué, Roser
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neutròfils
Immunosupressió
Autoanticossos
Inflamació
Vasculitis
Neutrophils
Immunosuppression
Autoantibodies
Inflammation
Vasculitis
topic Neutròfils
Immunosupressió
Autoanticossos
Inflamació
Vasculitis
Neutrophils
Immunosuppression
Autoantibodies
Inflammation
Vasculitis
description Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis is characterised by small vessel necrotising inflammatory vasculitis. Prior to immunosupressant therapy availability it usually led to a fatal outcome. Current treatment has changed ANCA-associated vasculitis into a condition with a significant response rate, although with a not negligible relapse occurrence and cumulative organ lesions, mostly due to drug-related toxicities. The use of glucocorticoids, cyclophosphamide and other immunosupressants (such as azathioprine, mychophenolate and methotrexate) was optimised in a series of clinical trials that established the treatment of reference. In recent years, a better knowledge of B lymphocyte function and the role of complement inhibition has transformed the course of this disease while minimising treatment-related adverse effects. This multidisciplinary document of recommendations is based on the consensus of three scientific societies (Internal Medicine, Nephrology and Rheumatology) and on the best available evidence on diagnosis, treatment and follow-up of patients with ANCA-associated vasculitis, including some special situations. The aim of this document is to provide updated information and well-grounded clinical recommendations to practising physicians as to how to improve the diagnosis and treatment outcome of our patients.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/220652
url https://hdl.handle.net/2445/220652
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.nefro.2024.07.004
Nefrología, 2025, vol. 45, num.1, p. 15-58
https://doi.org/10.1016/j.nefro.2024.07.004
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Morales, Enrique et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Morales, Enrique et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier España
publisher.none.fl_str_mv Elsevier España
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403586765520896
score 15,812429

Similar Items