UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept

Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient is a candidate for surgery. There are clinical guidelines for the management...

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Authors: Martínez-Useros, Javier, Georgiev-Hristov, Tihomir, Fernández-Aceñero, María Jesús, Borrero-Palacios, Aurea, Indacochea, Alberto, Guerrero, Santiago, Li, Weiyao, Cebrián, Arancha, Gómez del Pulgar, Teresa, Puime-Otin, Alberto, Puerto-Nevado, Laura del, Rodríguez-Remírez, María, Pérez, Nuria, Celdrán, Angel, Gebauer, Fátima, García-Foncillas López, Jesús Miguel
Format: article
Publication Date:2017
Country:España
Institution:Universidad Autónoma de Madrid
Repository:Biblos-e Archivo. Repositorio Institucional de la UAM
Language:English
OAI Identifier:oai:repositorio.uam.es:10486/681332
Online Access:http://hdl.handle.net/10486/681332
https://dx.doi.org/10.1371/journal. pone.0182044
Access Level:Open access
Keyword:Pancreatic ductal
Cancer
CDSE1
NRAS
PDAC
Medicina
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spelling UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-conceptMartínez-Useros, JavierGeorgiev-Hristov, TihomirFernández-Aceñero, María JesúsBorrero-Palacios, AureaIndacochea, AlbertoGuerrero, SantiagoLi, WeiyaoCebrián, AranchaGómez del Pulgar, TeresaPuime-Otin, AlbertoPuerto-Nevado, Laura delRodríguez-Remírez, MaríaPérez, NuriaCeldrán, AngelGebauer, FátimaGarcía-Foncillas López, Jesús MiguelPancreatic ductalCancerCDSE1NRASPDACMedicinaPancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient is a candidate for surgery. There are clinical guidelines for the management of these patients that offer different treatment options depending on the clinical and pathologic characteristics. However, the survival rates seen in this kind of patients are still low. The CDSE1 gene is located upstream of NRAS and encodes an RNA-binding protein termed UNR. The aim of this study was to analyze UNR expression and its correlation with outcome in patients with resectable pancreatic ductal adenocarcinoma (PDAC). For this, samples from resectable PDAC patients who underwent duodenopancreatectomy were used to evaluate UNR protein expression by immunohistochemistry using a tissue microarray. Here, we observed that low UNR expression was significantly associated with shorter progression-free survival after surgery (P = 0.010). Moreover, this prognostic marker remained significant after Cox proportional hazards model (P = 0.036). We further studied the role of CDSE1 expression in patient’s prognosis using data from public repositories (GEO and TGCA), confirming our results. Interestingly, CDSE1 expression correlated with that of genes characteristic of an immunogenic molecular subtype of pancreatic cancer. Based on these findings, UNR may be considered a potential prognostic biomarker for resectable PDAC and may serve to guide subsequent adjuvant treatment decisionsThis work has been carried out with the support of the RNA-Reg CONSOLIDER Network CSD2009-00080 (J.M.-U. and J.G.-F.), and Spanish Health Research Project Funds PI16/ 01468 from ªInstituto de Salud Carlos IIIº (A.C. and J.G.-F.), both of the Spanish Ministry of Economy, Industry and CompetitivenessPublic Library of ScienceDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)20172017-08-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/681332https://dx.doi.org/10.1371/journal. pone.0182044reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6813322026-06-23T12:46:27Z
dc.title.none.fl_str_mv UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
title UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
spellingShingle UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
Martínez-Useros, Javier
Pancreatic ductal
Cancer
CDSE1
NRAS
PDAC
Medicina
title_short UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
title_full UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
title_fullStr UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
title_full_unstemmed UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
title_sort UNR/CDSE1 expression as prognosis biomarker in resectable pancreatic ductal adenocarcinoma patients: A proof-of-concept
dc.creator.none.fl_str_mv Martínez-Useros, Javier
Georgiev-Hristov, Tihomir
Fernández-Aceñero, María Jesús
Borrero-Palacios, Aurea
Indacochea, Alberto
Guerrero, Santiago
Li, Weiyao
Cebrián, Arancha
Gómez del Pulgar, Teresa
Puime-Otin, Alberto
Puerto-Nevado, Laura del
Rodríguez-Remírez, María
Pérez, Nuria
Celdrán, Angel
Gebauer, Fátima
García-Foncillas López, Jesús Miguel
author Martínez-Useros, Javier
author_facet Martínez-Useros, Javier
Georgiev-Hristov, Tihomir
Fernández-Aceñero, María Jesús
Borrero-Palacios, Aurea
Indacochea, Alberto
Guerrero, Santiago
Li, Weiyao
Cebrián, Arancha
Gómez del Pulgar, Teresa
Puime-Otin, Alberto
Puerto-Nevado, Laura del
Rodríguez-Remírez, María
Pérez, Nuria
Celdrán, Angel
Gebauer, Fátima
García-Foncillas López, Jesús Miguel
author_role author
author2 Georgiev-Hristov, Tihomir
Fernández-Aceñero, María Jesús
Borrero-Palacios, Aurea
Indacochea, Alberto
Guerrero, Santiago
Li, Weiyao
Cebrián, Arancha
Gómez del Pulgar, Teresa
Puime-Otin, Alberto
Puerto-Nevado, Laura del
Rodríguez-Remírez, María
Pérez, Nuria
Celdrán, Angel
Gebauer, Fátima
García-Foncillas López, Jesús Miguel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
dc.subject.none.fl_str_mv Pancreatic ductal
Cancer
CDSE1
NRAS
PDAC
Medicina
topic Pancreatic ductal
Cancer
CDSE1
NRAS
PDAC
Medicina
description Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient is a candidate for surgery. There are clinical guidelines for the management of these patients that offer different treatment options depending on the clinical and pathologic characteristics. However, the survival rates seen in this kind of patients are still low. The CDSE1 gene is located upstream of NRAS and encodes an RNA-binding protein termed UNR. The aim of this study was to analyze UNR expression and its correlation with outcome in patients with resectable pancreatic ductal adenocarcinoma (PDAC). For this, samples from resectable PDAC patients who underwent duodenopancreatectomy were used to evaluate UNR protein expression by immunohistochemistry using a tissue microarray. Here, we observed that low UNR expression was significantly associated with shorter progression-free survival after surgery (P = 0.010). Moreover, this prognostic marker remained significant after Cox proportional hazards model (P = 0.036). We further studied the role of CDSE1 expression in patient’s prognosis using data from public repositories (GEO and TGCA), confirming our results. Interestingly, CDSE1 expression correlated with that of genes characteristic of an immunogenic molecular subtype of pancreatic cancer. Based on these findings, UNR may be considered a potential prognostic biomarker for resectable PDAC and may serve to guide subsequent adjuvant treatment decisions
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-08-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/681332
https://dx.doi.org/10.1371/journal. pone.0182044
url http://hdl.handle.net/10486/681332
https://dx.doi.org/10.1371/journal. pone.0182044
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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