Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance

Over the last decades, selection in cattle has mainly been based on milk production rather than on reproductive efficiency. While, when applied, focus on reproduction has involved females, attention has barely been paid to males and, if so, it has only looked at classical sperm quality parameters. I...

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Detalles Bibliográficos
Autores: Ribas Maynou, Jordi, Llavanera, Marc, Mateo Otero, Yentel, Ruiz, Nicolas, Muíño Otero, Rodrigo, Bonet, Sergi, Yeste Oliveras, Marc
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/21356
Acceso en línea:http://hdl.handle.net/10256/21356
Access Level:acceso abierto
Palabra clave:Telòmer
Telomere
Bestiar boví -- Espermatozoides
Cattle -- Spermatozoa
Espermatozoides -- Investigació
Spermatozoa -- Research
id ES_119c8ea4c332fa744a85540ddaff0be5
oai_identifier_str oai:recercat.cat:10256/21356
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
title Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
spellingShingle Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
Ribas Maynou, Jordi
Telòmer
Telomere
Bestiar boví -- Espermatozoides
Cattle -- Spermatozoa
Espermatozoides -- Investigació
Spermatozoa -- Research
title_short Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
title_full Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
title_fullStr Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
title_full_unstemmed Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
title_sort Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance
dc.creator.none.fl_str_mv Ribas Maynou, Jordi
Llavanera, Marc
Mateo Otero, Yentel
Ruiz, Nicolas
Muíño Otero, Rodrigo
Bonet, Sergi
Yeste Oliveras, Marc
author Ribas Maynou, Jordi
author_facet Ribas Maynou, Jordi
Llavanera, Marc
Mateo Otero, Yentel
Ruiz, Nicolas
Muíño Otero, Rodrigo
Bonet, Sergi
Yeste Oliveras, Marc
author_role author
author2 Llavanera, Marc
Mateo Otero, Yentel
Ruiz, Nicolas
Muíño Otero, Rodrigo
Bonet, Sergi
Yeste Oliveras, Marc
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación
dc.subject.none.fl_str_mv Telòmer
Telomere
Bestiar boví -- Espermatozoides
Cattle -- Spermatozoa
Espermatozoides -- Investigació
Spermatozoa -- Research
topic Telòmer
Telomere
Bestiar boví -- Espermatozoides
Cattle -- Spermatozoa
Espermatozoides -- Investigació
Spermatozoa -- Research
description Over the last decades, selection in cattle has mainly been based on milk production rather than on reproductive efficiency. While, when applied, focus on reproduction has involved females, attention has barely been paid to males and, if so, it has only looked at classical sperm quality parameters. In effect, variables such as telomere length have been missed, despite the fact that longer telomeres have been suggested to be linked to male fertility in humans. For this reason, the present study aimed to determine the length of telomeres in bovine sperm and their relationship with a) sperm quality evaluated through the conventional spermiogram and flow cytometry, and b) bull reproductive performance. For this purpose, 29 bulls were involved in this study. Sperm telomere length was evaluated through quantitative Fluorescent In Situ Hybridization (qFISH), and sperm quality was determined at 0 h and 4 h post-thaw. Bull fertility was assessed as non-return to estrus rates after 90 days of artificial insemination. Although the mean telomere length in bovine sperm was 12.06 ± 2.75 kb, the intra-individual variability in length led us to observe three different groups of telomeres in each sperm cell: short telomeres (7.14% ± 5.79% of telomeres; 8.29 ± 2.34 kb), medium telomeres (31.03% ± 12.92% of telomeres; 16.00 ± 2.72 kb) and long telomeres (61.93% ± 18.11% of telomeres; 30.13 ± 11.35 kb). Moreover, whereas reactive oxygen species (ROS) were found to be correlated to sperm telomere length (Rs = −0.492; P= 0.007), no correlation with other sperm quality parameters was found (P > 0.05). Reproductive performance after artificial insemination was not seen to be correlated to sperm telomere length (Rs = 0.123; P= 0.520). In conclusion, this study determined, for the first time, the mean telomere length in bovine sperm and also reported that there is a high variability within each sperm cell. Yet, while telomere length was found to be correlated to ROS generation, it was not related to bull reproductive performance
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer-reviewed
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/21356
http://hdl.handle.net/10256/21356
url http://hdl.handle.net/10256/21356
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.theriogenology.2022.06.025
info:eu-repo/semantics/altIdentifier/issn/0093-691X
info:eu-repo/semantics/altIdentifier/eissn/1879-3231
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-88329-R
dc.rights.none.fl_str_mv Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reconeixement-NoComercial-SenseObraDerivada 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Theriogenology, 2022, vol. 189, p. 290-300
Articles publicats (D-B)
Ribas Maynou, Jordi Llavanera, Marc Mateo Otero, Yentel Ruiz, Nicolas Muiño, Rodrigo Bonet, Sergi Yeste Oliveras, Marc 2022 Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance Theriogenology 189 290 300
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performanceRibas Maynou, JordiLlavanera, MarcMateo Otero, YentelRuiz, NicolasMuíño Otero, RodrigoBonet, SergiYeste Oliveras, MarcTelòmerTelomereBestiar boví -- EspermatozoidesCattle -- SpermatozoaEspermatozoides -- InvestigacióSpermatozoa -- ResearchOver the last decades, selection in cattle has mainly been based on milk production rather than on reproductive efficiency. While, when applied, focus on reproduction has involved females, attention has barely been paid to males and, if so, it has only looked at classical sperm quality parameters. In effect, variables such as telomere length have been missed, despite the fact that longer telomeres have been suggested to be linked to male fertility in humans. For this reason, the present study aimed to determine the length of telomeres in bovine sperm and their relationship with a) sperm quality evaluated through the conventional spermiogram and flow cytometry, and b) bull reproductive performance. For this purpose, 29 bulls were involved in this study. Sperm telomere length was evaluated through quantitative Fluorescent In Situ Hybridization (qFISH), and sperm quality was determined at 0 h and 4 h post-thaw. Bull fertility was assessed as non-return to estrus rates after 90 days of artificial insemination. Although the mean telomere length in bovine sperm was 12.06 ± 2.75 kb, the intra-individual variability in length led us to observe three different groups of telomeres in each sperm cell: short telomeres (7.14% ± 5.79% of telomeres; 8.29 ± 2.34 kb), medium telomeres (31.03% ± 12.92% of telomeres; 16.00 ± 2.72 kb) and long telomeres (61.93% ± 18.11% of telomeres; 30.13 ± 11.35 kb). Moreover, whereas reactive oxygen species (ROS) were found to be correlated to sperm telomere length (Rs = −0.492; P= 0.007), no correlation with other sperm quality parameters was found (P > 0.05). Reproductive performance after artificial insemination was not seen to be correlated to sperm telomere length (Rs = 0.123; P= 0.520). In conclusion, this study determined, for the first time, the mean telomere length in bovine sperm and also reported that there is a high variability within each sperm cell. Yet, while telomere length was found to be correlated to ROS generation, it was not related to bull reproductive performanceThe present study was funded by the Ministry of Science and Innovation, Spain (AGL2017-88329-R and PID2020-113320RB-I00), the Regional Government of Catalonia, Spain (2017-SGR-1229 and 2020-FI-B-00412), the European Commission (H2020 Research and Innovation program under the Marie Skłodowska-Curie grant agreement No 801342; Tecniospring INDUSTRY, TECSPR-19-1- 0003), and La Marato de TV3 Foundation (Grant: 214/857-202039)Open Access funding provided thanks to the CRUE-CSIC agreement with ElsevierElsevierAgencia Estatal de Investigación2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer-reviewed11 p.application/pdfhttp://hdl.handle.net/10256/21356http://hdl.handle.net/10256/21356Theriogenology, 2022, vol. 189, p. 290-300Articles publicats (D-B)Ribas Maynou, Jordi Llavanera, Marc Mateo Otero, Yentel Ruiz, Nicolas Muiño, Rodrigo Bonet, Sergi Yeste Oliveras, Marc 2022 Telomere length in bovine sperm is related to the production of reactive oxygen species, but not to reproductive performance Theriogenology 189 290 300reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.theriogenology.2022.06.025info:eu-repo/semantics/altIdentifier/issn/0093-691Xinfo:eu-repo/semantics/altIdentifier/eissn/1879-3231info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-88329-RReconeixement-NoComercial-SenseObraDerivada 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessoai:recercat.cat:10256/213562026-05-29T05:05:01Z
score 15,81155

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