New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy

Alzheimer's disease (AD) is characterized by the presence of two aberrant structures: namely senile plaques, composed of amyloid-β peptide (Aβ), and neurofibrillary tangles, composed of tau protein. In this regard, Aβ and tau protein have been widely studied in research efforts aiming to find a...

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Detalles Bibliográficos
Autores: Hernández, Félix, Llorens-Martín, María, Bolós, Marta, Pérez, Mar, Cuadros, Raquel, Pallas-Bazarra, Noemí, Zabala, Juan Carlos, Ávila, Jesús
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/254088
Acceso en línea:http://hdl.handle.net/10261/254088
Access Level:acceso abierto
Palabra clave:Extracellular tau
MAPs
Tau functions
Tauopathies
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spelling New Beginnings in Alzheimer's Disease: The Most Prevalent TauopathyHernández, FélixLlorens-Martín, MaríaBolós, MartaPérez, MarCuadros, RaquelPallas-Bazarra, NoemíZabala, Juan CarlosÁvila, JesúsExtracellular tauMAPsTau functionsTauopathiesAlzheimer's disease (AD) is characterized by the presence of two aberrant structures: namely senile plaques, composed of amyloid-β peptide (Aβ), and neurofibrillary tangles, composed of tau protein. In this regard, Aβ and tau protein have been widely studied in research efforts aiming to find a therapy for AD. Aβ and tau pathologies do not always overlap. The precursor of Aβ is expressed in peripheral tissues and in the central nervous system (CNS), whereas tau is mainly a neuronal protein. Since AD is a disease of the CNS, it has been proposed that Aβ may initiate the disease process, with tau being the executor. In this review, we will focus on future studies of tau pathology, although we will comment on new beginnings for AD, as other molecules other than Aβ and tau may be involved in the onset of dementia.IOS PressConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120182021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/254088reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3233/JAD-179916Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2540882026-05-22T06:33:51Z
dc.title.none.fl_str_mv New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
title New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
spellingShingle New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
Hernández, Félix
Extracellular tau
MAPs
Tau functions
Tauopathies
title_short New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
title_full New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
title_fullStr New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
title_full_unstemmed New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
title_sort New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy
dc.creator.none.fl_str_mv Hernández, Félix
Llorens-Martín, María
Bolós, Marta
Pérez, Mar
Cuadros, Raquel
Pallas-Bazarra, Noemí
Zabala, Juan Carlos
Ávila, Jesús
author Hernández, Félix
author_facet Hernández, Félix
Llorens-Martín, María
Bolós, Marta
Pérez, Mar
Cuadros, Raquel
Pallas-Bazarra, Noemí
Zabala, Juan Carlos
Ávila, Jesús
author_role author
author2 Llorens-Martín, María
Bolós, Marta
Pérez, Mar
Cuadros, Raquel
Pallas-Bazarra, Noemí
Zabala, Juan Carlos
Ávila, Jesús
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Extracellular tau
MAPs
Tau functions
Tauopathies
topic Extracellular tau
MAPs
Tau functions
Tauopathies
description Alzheimer's disease (AD) is characterized by the presence of two aberrant structures: namely senile plaques, composed of amyloid-β peptide (Aβ), and neurofibrillary tangles, composed of tau protein. In this regard, Aβ and tau protein have been widely studied in research efforts aiming to find a therapy for AD. Aβ and tau pathologies do not always overlap. The precursor of Aβ is expressed in peripheral tissues and in the central nervous system (CNS), whereas tau is mainly a neuronal protein. Since AD is a disease of the CNS, it has been proposed that Aβ may initiate the disease process, with tau being the executor. In this review, we will focus on future studies of tau pathology, although we will comment on new beginnings for AD, as other molecules other than Aβ and tau may be involved in the onset of dementia.
publishDate 2018
dc.date.none.fl_str_mv 2018
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/254088
url http://hdl.handle.net/10261/254088
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3233/JAD-179916
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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