Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors

Background: Epidemiological studies have shown that ambient particulate matter (PM) and changes in air temperature are associated with increased cardiopulmonary events. Objective: We hypothesized that patients with previous myocardial infarction (MI) experience changes in heart rate (HR) and repolar...

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Autores: Hampel, Regina, Schneider, Alexandra, Brüske, Irene, Zareba, Wojciech, Cyrys, Josef, Rückerl, Regina, Breitner, Susanne, Korb, Harald, Sunyer Deu, Jordi, Wichmann, H. Erich, Peters, Annette
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/23353
Acceso en línea:http://hdl.handle.net/10230/23353
http://dx.doi.org/10.1289/ehp.1001995
Access Level:acceso abierto
Palabra clave:Aire -- Contaminació -- Efectes fisiològics -- Epidemiologia
Hipertensió
Air pollution
Air temperature
Epidemiology
Myocardial infarction
Panel study
Repolarization
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spelling Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivorsHampel, ReginaSchneider, AlexandraBrüske, IreneZareba, WojciechCyrys, JosefRückerl, ReginaBreitner, SusanneKorb, HaraldSunyer Deu, JordiWichmann, H. ErichPeters, AnnetteAire -- Contaminació -- Efectes fisiològics -- EpidemiologiaHipertensióAir pollutionAir temperatureEpidemiologyMyocardial infarctionPanel studyRepolarizationBackground: Epidemiological studies have shown that ambient particulate matter (PM) and changes in air temperature are associated with increased cardiopulmonary events. Objective: We hypothesized that patients with previous myocardial infarction (MI) experience changes in heart rate (HR) and repolarization parameters, such as Bazett-corrected QT interval (QTc), and T-wave amplitude (Tamp), in association with increases in air pollution and temperature changes. Methods: Between May 2003 and February 2004, 67 MI survivors from the Augsburg KORA-MI registry repeatedly sent 16 sec electrocardiograms (ECGs) with a personal transmitter (Viapac) via telephone to the Philips Monitoring Center, where ECG parameters were immediately analyzed. Meteorological data and air pollutants were acquired from fixed monitoring sites on an hourly basis. Additive mixed models were used for analysis. Effect modification by patient characteristics was investigated. Results: The analysis of the 1,745 ECGs revealed an increased HR associated with interquartile range (IQR) increases in PM levels among participants not using beta-adrenergic receptor blockers and among those with body mass index ≥ 30 kg/m2. We observed a 24- to 47-hr lagged QTc prolongation [0.5% change (95% confidence interval, 0.0–1.0%)] in association with IQR increases in levels of PM ≤ 2.5 µm in aerodynamic diameter, especially in patients with one [0.6% (0.1–1.0%)] or two [1.2% (0.4–2.1%)] minor alleles of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) single-nucleotide polymorphism rs2364725. Positive immediate (0–23 hr) and inverse delayed (48–71 hr up to 96–119 hr) associations were evident between PM and Tamp. We detected an inverse U-shaped association between temperature and Tamp, with a maximum Tamp at 5°C. Conclusions: Increased air pollution levels and temperature changes may lead to changes in HR and repolarization parameters that may be precursors of cardiac problems.The AIRGENE study was funded as part of the European Union’s 5th Framework Programme, key action 4: “Environment and Health,” contract QLRT-2002-02236. This research has been funded wholly or in part by the U.S. Environmental Protection Agency through Science to Achieve Results grants RD827354 and RD832415 to the University of RochesterNational Institute of Environmental Health Sciences (NIEHS)201520152010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23353http://dx.doi.org/10.1289/ehp.1001995reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEnvironmental Health Perspectives. 2010;118(12):1755-61info:eu-repo/grantAgreement/EC/FP5/02236Reproduced with permission from Environmental Health Perspectivesinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/233532026-05-29T05:05:01Z
dc.title.none.fl_str_mv Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
title Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
spellingShingle Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
Hampel, Regina
Aire -- Contaminació -- Efectes fisiològics -- Epidemiologia
Hipertensió
Air pollution
Air temperature
Epidemiology
Myocardial infarction
Panel study
Repolarization
title_short Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
title_full Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
title_fullStr Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
title_full_unstemmed Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
title_sort Altered cardiac repolarization in association with air pollution and air temperature among myocardial infarction survivors
dc.creator.none.fl_str_mv Hampel, Regina
Schneider, Alexandra
Brüske, Irene
Zareba, Wojciech
Cyrys, Josef
Rückerl, Regina
Breitner, Susanne
Korb, Harald
Sunyer Deu, Jordi
Wichmann, H. Erich
Peters, Annette
author Hampel, Regina
author_facet Hampel, Regina
Schneider, Alexandra
Brüske, Irene
Zareba, Wojciech
Cyrys, Josef
Rückerl, Regina
Breitner, Susanne
Korb, Harald
Sunyer Deu, Jordi
Wichmann, H. Erich
Peters, Annette
author_role author
author2 Schneider, Alexandra
Brüske, Irene
Zareba, Wojciech
Cyrys, Josef
Rückerl, Regina
Breitner, Susanne
Korb, Harald
Sunyer Deu, Jordi
Wichmann, H. Erich
Peters, Annette
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aire -- Contaminació -- Efectes fisiològics -- Epidemiologia
Hipertensió
Air pollution
Air temperature
Epidemiology
Myocardial infarction
Panel study
Repolarization
topic Aire -- Contaminació -- Efectes fisiològics -- Epidemiologia
Hipertensió
Air pollution
Air temperature
Epidemiology
Myocardial infarction
Panel study
Repolarization
description Background: Epidemiological studies have shown that ambient particulate matter (PM) and changes in air temperature are associated with increased cardiopulmonary events. Objective: We hypothesized that patients with previous myocardial infarction (MI) experience changes in heart rate (HR) and repolarization parameters, such as Bazett-corrected QT interval (QTc), and T-wave amplitude (Tamp), in association with increases in air pollution and temperature changes. Methods: Between May 2003 and February 2004, 67 MI survivors from the Augsburg KORA-MI registry repeatedly sent 16 sec electrocardiograms (ECGs) with a personal transmitter (Viapac) via telephone to the Philips Monitoring Center, where ECG parameters were immediately analyzed. Meteorological data and air pollutants were acquired from fixed monitoring sites on an hourly basis. Additive mixed models were used for analysis. Effect modification by patient characteristics was investigated. Results: The analysis of the 1,745 ECGs revealed an increased HR associated with interquartile range (IQR) increases in PM levels among participants not using beta-adrenergic receptor blockers and among those with body mass index ≥ 30 kg/m2. We observed a 24- to 47-hr lagged QTc prolongation [0.5% change (95% confidence interval, 0.0–1.0%)] in association with IQR increases in levels of PM ≤ 2.5 µm in aerodynamic diameter, especially in patients with one [0.6% (0.1–1.0%)] or two [1.2% (0.4–2.1%)] minor alleles of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) single-nucleotide polymorphism rs2364725. Positive immediate (0–23 hr) and inverse delayed (48–71 hr up to 96–119 hr) associations were evident between PM and Tamp. We detected an inverse U-shaped association between temperature and Tamp, with a maximum Tamp at 5°C. Conclusions: Increased air pollution levels and temperature changes may lead to changes in HR and repolarization parameters that may be precursors of cardiac problems.
publishDate 2010
dc.date.none.fl_str_mv 2010
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/23353
http://dx.doi.org/10.1289/ehp.1001995
url http://hdl.handle.net/10230/23353
http://dx.doi.org/10.1289/ehp.1001995
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental Health Perspectives. 2010;118(12):1755-61
info:eu-repo/grantAgreement/EC/FP5/02236
dc.rights.none.fl_str_mv Reproduced with permission from Environmental Health Perspectives
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Reproduced with permission from Environmental Health Perspectives
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
publisher.none.fl_str_mv National Institute of Environmental Health Sciences (NIEHS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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