Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort

Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water. Chronic exposure has been associated with increased cancer risk despite inconclusive evidence, partly due to the challenges in long-term exposure assessment and potential exposure misclassification. We estimated concentra...

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Autores: Lafontaine, Antoine, Lee, Sewon, Jacquemin Leonard, Bénédicte, Glorennec, Philippe, Le Bot, Barbara, Verrey, Dominique, Goldberg, Marcel, Zins, Marie, Lequy, Emeline, Villanueva Belmonte, Cristina
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/68703
Acesso em linha:http://hdl.handle.net/10230/68703
http://dx.doi.org/10.1016/j.envres.2024.119557
Access Level:acceso abierto
Palavra-chave:Chemical safety
Disinfection by-products
Environmental monitoring
Exposure assessment
Public health
Water quality
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spelling Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohortLafontaine, AntoineLee, SewonJacquemin Leonard, BénédicteGlorennec, PhilippeLe Bot, BarbaraVerrey, DominiqueGoldberg, MarcelZins, MarieLequy, EmelineVillanueva Belmonte, CristinaChemical safetyDisinfection by-productsEnvironmental monitoringExposure assessmentPublic healthWater qualityTrihalomethanes (THMs) and nitrate are widespread chemicals in drinking water. Chronic exposure has been associated with increased cancer risk despite inconclusive evidence, partly due to the challenges in long-term exposure assessment and potential exposure misclassification. We estimated concentrations of nitrate and THMs in drinking water using a public regulatory monitoring database (SISE-Eaux) for CONSTANCES, a French population-based prospective cohort. We obtained 26,322,366 measurements of drinking water parameters from 2000 to 2020. We excluded missing, implausible and duplicated measurements; we corrected or imputed missing geocodes of sampling locations; we calculated the annual median concentration of nitrate and THMs by surveillance area. To predict missing annual median concentrations, linear mixed models with random intercept using surveillance area as a clustering variable were developed for each region for nitrate and the four THM components (chloroform, chlorodibromomethane, bromodichloromethane and bromoform) separately. Concentrations in the nearest surveillance area from the household were merged per year among 75,462 participants with residential history geocoded for 2000-2020. Estimated concentrations resulting from this approach were compared with measured concentrations in 100 samples collected in Paris, Rennes and Saint-Brieuc in 2021. Median annual concentrations of total THMs and nitrate at study participants' homes for 2000-2020 were, respectively, 15.7 μg/l (IQR: 15.2) and 15.2 mg/l (IQR: 20.8). Among these, 35% were based on measurements for nitrate (16% for THMs), 44% (46%) were predicted using on linear mixed models, and 21% (38%) were based on distribution unit median values. Conditional R2 predictive models ranged from 0.71 to 0.91 (median: 0.85) for nitrate, and from 0.48 to 0.80 for THMs (median: 0.68). These concentrations will allow future association analyses with risk of breast and colorectal cancer. Our cleaning process introduced here could be adapted to other large drinking water monitoring data.Elsevier202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/68703http://dx.doi.org/10.1016/j.envres.2024.119557reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnviron Res. 2024 Oct 15;259:119557© 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/687032026-06-12T07:21:37Z
dc.title.none.fl_str_mv Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
title Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
spellingShingle Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
Lafontaine, Antoine
Chemical safety
Disinfection by-products
Environmental monitoring
Exposure assessment
Public health
Water quality
title_short Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
title_full Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
title_fullStr Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
title_full_unstemmed Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
title_sort Chronic exposure to drinking water nitrate and trihalomethanes in the French CONSTANCES cohort
dc.creator.none.fl_str_mv Lafontaine, Antoine
Lee, Sewon
Jacquemin Leonard, Bénédicte
Glorennec, Philippe
Le Bot, Barbara
Verrey, Dominique
Goldberg, Marcel
Zins, Marie
Lequy, Emeline
Villanueva Belmonte, Cristina
author Lafontaine, Antoine
author_facet Lafontaine, Antoine
Lee, Sewon
Jacquemin Leonard, Bénédicte
Glorennec, Philippe
Le Bot, Barbara
Verrey, Dominique
Goldberg, Marcel
Zins, Marie
Lequy, Emeline
Villanueva Belmonte, Cristina
author_role author
author2 Lee, Sewon
Jacquemin Leonard, Bénédicte
Glorennec, Philippe
Le Bot, Barbara
Verrey, Dominique
Goldberg, Marcel
Zins, Marie
Lequy, Emeline
Villanueva Belmonte, Cristina
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chemical safety
Disinfection by-products
Environmental monitoring
Exposure assessment
Public health
Water quality
topic Chemical safety
Disinfection by-products
Environmental monitoring
Exposure assessment
Public health
Water quality
description Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water. Chronic exposure has been associated with increased cancer risk despite inconclusive evidence, partly due to the challenges in long-term exposure assessment and potential exposure misclassification. We estimated concentrations of nitrate and THMs in drinking water using a public regulatory monitoring database (SISE-Eaux) for CONSTANCES, a French population-based prospective cohort. We obtained 26,322,366 measurements of drinking water parameters from 2000 to 2020. We excluded missing, implausible and duplicated measurements; we corrected or imputed missing geocodes of sampling locations; we calculated the annual median concentration of nitrate and THMs by surveillance area. To predict missing annual median concentrations, linear mixed models with random intercept using surveillance area as a clustering variable were developed for each region for nitrate and the four THM components (chloroform, chlorodibromomethane, bromodichloromethane and bromoform) separately. Concentrations in the nearest surveillance area from the household were merged per year among 75,462 participants with residential history geocoded for 2000-2020. Estimated concentrations resulting from this approach were compared with measured concentrations in 100 samples collected in Paris, Rennes and Saint-Brieuc in 2021. Median annual concentrations of total THMs and nitrate at study participants' homes for 2000-2020 were, respectively, 15.7 μg/l (IQR: 15.2) and 15.2 mg/l (IQR: 20.8). Among these, 35% were based on measurements for nitrate (16% for THMs), 44% (46%) were predicted using on linear mixed models, and 21% (38%) were based on distribution unit median values. Conditional R2 predictive models ranged from 0.71 to 0.91 (median: 0.85) for nitrate, and from 0.48 to 0.80 for THMs (median: 0.68). These concentrations will allow future association analyses with risk of breast and colorectal cancer. Our cleaning process introduced here could be adapted to other large drinking water monitoring data.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/68703
http://dx.doi.org/10.1016/j.envres.2024.119557
url http://hdl.handle.net/10230/68703
http://dx.doi.org/10.1016/j.envres.2024.119557
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environ Res. 2024 Oct 15;259:119557
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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