Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells

Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with characteristic movement impairments that are caused by the progressive loss of dopamine-containing neurons (DAn) within the substantia nigra pars compacta. It has been suggested that misfolded protein aggregates...

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Autores: Pons-Espinal, Meritxell, Blasco Agell, Lucas, Consiglio, Antonella
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/188052
Acceso en línea:https://hdl.handle.net/2445/188052
Access Level:acceso abierto
Palabra clave:Malaltia de Parkinson
Cèl·lules mare
Neuròglia
Modelatge
Parkinson's disease
Stem cells
Neuroglia
Modeling
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spelling Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cellsPons-Espinal, MeritxellBlasco Agell, LucasConsiglio, AntonellaMalaltia de ParkinsonCèl·lules mareNeurògliaModelatgeParkinson's diseaseStem cellsNeurogliaModelingParkinson's disease (PD) is an incurable age-linked neurodegenerative disease with characteristic movement impairments that are caused by the progressive loss of dopamine-containing neurons (DAn) within the substantia nigra pars compacta. It has been suggested that misfolded protein aggregates together with neuroinfammation and glial reactivity, may impact nerve cell function, leading to neurodegeneration and diseases, such as PD. However, not many studies have been able to examine the role of human glial cells in the pathogenesis of PD. With the advent of induced pluripotent stem cell (iPSC) technology, it is now possible to reprogram human somatic cells to pluripotency and to generate viable human patient-specifc DA neurons and glial cells, providing a tremendous opportunity for dissecting cellular and molecular pathological mechanisms occurring at early stages of PD. This reviews will report on recent work using human iPSC and 3D brain organoid models showing that iPSC technology can be used to recapitulate PD-relevant disease-associated phenotypes, including protein aggregation, cell death or loss of neurite complexity and defcient autophagic vacuoles clearance and focus on the recent co-culture systems that are revealing new insights into the complex interactions that occur between diferent brain cell types during neurodegeneration. Consequently, such advances are the key to improve our understanding of PD pathology and generate potential targets for new therapies aimed at curing PD patients.Springer Verlag2022202220202022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/188052Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00018-020-03700-xCellular and Molecular Life Sciences, 2020, vol. 78, num. 5, p. 2081-2094https://doi.org/10.1007/s00018-020-03700-xinfo:eu-repo/grantAgreement/EC/FP7/311736cc by Pons Espinal, Meritxell (c) Springer Verlag, 2020https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1880522026-05-29T05:05:01Z
dc.title.none.fl_str_mv Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
title Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
spellingShingle Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
Pons-Espinal, Meritxell
Malaltia de Parkinson
Cèl·lules mare
Neuròglia
Modelatge
Parkinson's disease
Stem cells
Neuroglia
Modeling
title_short Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
title_full Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
title_fullStr Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
title_full_unstemmed Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
title_sort Dissecting the non-neuronal cell contribution to Parkinson's disease pathogenesis using induced pluripotent stem cells
dc.creator.none.fl_str_mv Pons-Espinal, Meritxell
Blasco Agell, Lucas
Consiglio, Antonella
author Pons-Espinal, Meritxell
author_facet Pons-Espinal, Meritxell
Blasco Agell, Lucas
Consiglio, Antonella
author_role author
author2 Blasco Agell, Lucas
Consiglio, Antonella
author2_role author
author
dc.subject.none.fl_str_mv Malaltia de Parkinson
Cèl·lules mare
Neuròglia
Modelatge
Parkinson's disease
Stem cells
Neuroglia
Modeling
topic Malaltia de Parkinson
Cèl·lules mare
Neuròglia
Modelatge
Parkinson's disease
Stem cells
Neuroglia
Modeling
description Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with characteristic movement impairments that are caused by the progressive loss of dopamine-containing neurons (DAn) within the substantia nigra pars compacta. It has been suggested that misfolded protein aggregates together with neuroinfammation and glial reactivity, may impact nerve cell function, leading to neurodegeneration and diseases, such as PD. However, not many studies have been able to examine the role of human glial cells in the pathogenesis of PD. With the advent of induced pluripotent stem cell (iPSC) technology, it is now possible to reprogram human somatic cells to pluripotency and to generate viable human patient-specifc DA neurons and glial cells, providing a tremendous opportunity for dissecting cellular and molecular pathological mechanisms occurring at early stages of PD. This reviews will report on recent work using human iPSC and 3D brain organoid models showing that iPSC technology can be used to recapitulate PD-relevant disease-associated phenotypes, including protein aggregation, cell death or loss of neurite complexity and defcient autophagic vacuoles clearance and focus on the recent co-culture systems that are revealing new insights into the complex interactions that occur between diferent brain cell types during neurodegeneration. Consequently, such advances are the key to improve our understanding of PD pathology and generate potential targets for new therapies aimed at curing PD patients.
publishDate 2020
dc.date.none.fl_str_mv 2020
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/188052
url https://hdl.handle.net/2445/188052
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00018-020-03700-x
Cellular and Molecular Life Sciences, 2020, vol. 78, num. 5, p. 2081-2094
https://doi.org/10.1007/s00018-020-03700-x
info:eu-repo/grantAgreement/EC/FP7/311736
dc.rights.none.fl_str_mv cc by Pons Espinal, Meritxell (c) Springer Verlag, 2020
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by Pons Espinal, Meritxell (c) Springer Verlag, 2020
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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