Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research

This article is part of the Thematic Series "From prebiotic chemistry to molecular evolution".

Detalles Bibliográficos
Autores: Shirt-Ediss, Ben, Murillo-Sánchez, Sara, Ruiz-Mirazo, Kepa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/417064
Acceso en línea:http://hdl.handle.net/10261/417064
Access Level:acceso abierto
Palabra clave:Functional integration
Origins of life
Prebiotic evolution
Protocells
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spelling Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life researchShirt-Ediss, BenMurillo-Sánchez, SaraRuiz-Mirazo, KepaFunctional integrationOrigins of lifePrebiotic evolutionProtocellsThis article is part of the Thematic Series "From prebiotic chemistry to molecular evolution".Conceiving the process of biogenesis as the evolutionary development of highly dynamic and integrated protocell populations provides the most appropriate framework to address the difficult problem of how prebiotic chemistry bridged the gap to full-fledged living organisms on the early Earth. In this contribution we briefly discuss the implications of taking dynamic, functionally integrated protocell systems (rather than complex reaction networks in bulk solution, sets of artificially evolvable replicating molecules, or even these same replicating molecules encapsulated in passive compartments) as the proper units of prebiotic evolution. We highlight, in particular, how the organisational features of those chemically active and reactive protocells, at different stages of the process, would strongly influence their corresponding evolutionary capacities. As a result of our analysis, we suggest three experimental challenges aimed at constructing protocell systems made of a diversity of functionally coupled components and, thereby, at characterizing more precisely the type of prebiotic evolutionary dynamics that such protocells could engage in.KR-M’s research received financial support from the Basque Government (IT 590-13 Grant) and from the Spanish Ministry of Economía y Competitividad (MINECO, grant FFI2014-52173-P). Authors also acknowledge the help for European networking and interactions provided by COST Actions CM1304 (‘Emergence and evolution of complex chemical systems’) and TD1308 (‘Origins and evolution of life on Earth and in the Universe’).Peer reviewedBeilstein InstitutEusko JaurlaritzaMinisterio de Economía y Competitividad (España)European Cooperation in Science and TechnologyShirt-Ediss, Ben [0000-0002-8853-0182]Ruiz-Mirazo, Kepa [0000-0002-0157-4394]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/417064reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//FFI2014-52173-Phttps://doi.org/10.3762/bjoc.13.135Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4170642026-05-22T06:33:51Z
dc.title.none.fl_str_mv Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
title Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
spellingShingle Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
Shirt-Ediss, Ben
Functional integration
Origins of life
Prebiotic evolution
Protocells
title_short Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
title_full Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
title_fullStr Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
title_full_unstemmed Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
title_sort Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research
dc.creator.none.fl_str_mv Shirt-Ediss, Ben
Murillo-Sánchez, Sara
Ruiz-Mirazo, Kepa
author Shirt-Ediss, Ben
author_facet Shirt-Ediss, Ben
Murillo-Sánchez, Sara
Ruiz-Mirazo, Kepa
author_role author
author2 Murillo-Sánchez, Sara
Ruiz-Mirazo, Kepa
author2_role author
author
dc.contributor.none.fl_str_mv Eusko Jaurlaritza
Ministerio de Economía y Competitividad (España)
European Cooperation in Science and Technology
Shirt-Ediss, Ben [0000-0002-8853-0182]
Ruiz-Mirazo, Kepa [0000-0002-0157-4394]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Functional integration
Origins of life
Prebiotic evolution
Protocells
topic Functional integration
Origins of life
Prebiotic evolution
Protocells
description This article is part of the Thematic Series "From prebiotic chemistry to molecular evolution".
publishDate 2017
dc.date.none.fl_str_mv 2017
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/417064
url http://hdl.handle.net/10261/417064
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//FFI2014-52173-P
https://doi.org/10.3762/bjoc.13.135
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Beilstein Institut
publisher.none.fl_str_mv Beilstein Institut
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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