The Experiment Data Depot: A Web-Based Software Tool for Biological Experimental Data Storage, Sharing, and Visualization

Although recent advances in synthetic biology allow us to produce biological designs more efficiently than ever, our ability to predict the end result of these designs is still nascent. Predictive models require large amounts of high-quality data to be parametrized and tested, which are not generall...

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Bibliographic Details
Authors: Morrell, W.C., Birkel, G.W., Forrer, M., Lopez, T., Backman, T.W.H., Dussault, M., Petzold, C.J., Baidoo, E.E.K., Costello, Z., Ando, D., Alonso-Gutierrez, J., George, K.W., Mukhopadhyay, A., Vaino, I., Keasling, J.D., Adams, P.D., Hillson, N.J., Garcia-Martin, H.
Format: article
Status:Versión aceptada para publicación
Publication Date:2017
Country:España
Institution:Basque Center for Applied Mathematics (BCAM)
Repository:BIRD. BCAM's Institutional Repository Data
OAI Identifier:oai:bird.bcamath.org:20.500.11824/736
Online Access:http://hdl.handle.net/20.500.11824/736
Access Level:Open access
Keyword:-omics data
data mining
data standards
database
flux analysis
synthetic biology
Description
Summary:Although recent advances in synthetic biology allow us to produce biological designs more efficiently than ever, our ability to predict the end result of these designs is still nascent. Predictive models require large amounts of high-quality data to be parametrized and tested, which are not generally available. Here, we present the Experiment Data Depot (EDD), an online tool designed as a repository of experimental data and metadata. EDD provides a convenient way to upload a variety of data types, visualize these data, and export them in a standardized fashion for use with predictive algorithms. In this paper, we describe EDD and showcase its utility for three different use cases: storage of characterized synthetic biology parts, leveraging proteomics data to improve biofuel yield, and the use of extracellular metabolite concentrations to predict intracellular metabolic fluxes.