Association between anticholinergic burden and constipation: a systematic review

The association between anticholinergic burden and constipation is not well defined and documented; for this reason, a systematic review was carried out in five databases (Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus), including studies assessing the correlatio...

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Autores: Rodríguez-Ramallo, Héctor, Báez-Gutiérrez, Nerea, Prado-Mel, Elena, Alfaro Lara, Eva Rocío, Santos Ramos, Bernardo, Sánchez Fidalgo, Susana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/115990
Acceso en línea:https://hdl.handle.net/11441/115990
https://doi.org/10.3390/healthcare9050581
Access Level:acceso abierto
Palabra clave:Anticholinergic burden
Anticholinergic scale
Anticholinergic drugs
Constipation
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spelling Association between anticholinergic burden and constipation: a systematic reviewRodríguez-Ramallo, HéctorBáez-Gutiérrez, NereaPrado-Mel, ElenaAlfaro Lara, Eva RocíoSantos Ramos, BernardoSánchez Fidalgo, SusanaAnticholinergic burdenAnticholinergic scaleAnticholinergic drugsConstipationThe association between anticholinergic burden and constipation is not well defined and documented; for this reason, a systematic review was carried out in five databases (Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus), including studies assessing the correlation between anticholinergic burden, and constipation between January 2006 and December 2020. Data extraction was conducted independently by two researchers. Abstracts and titles were reviewed to determine eligibility for review with eligible articles read in full. From 2507 identified articles, 11 were selected for this review: six cross-sectional studies, four retrospective cohort studies, and a post hoc analysis of a randomized clinical trial. Overall, nine studies reported at least one statistical association between anticholinergic burden and constipation, finding 13 positive results out of 24 association measurements. A total of 211,921 patients were studied. The association between constipation and anticholinergic burden could be demonstrated in studies including 207,795 patients. Most studies were not designed to find differences in constipation prevalence and did not adjust the results by confounding factors. Our findings suggest that a correlation between anticholinergic burden and constipation exists. Higher quality-evidence studies are needed, including analysis that considers confounding factors, such as other non-pharmacological causes of constipation.MDPIMedicina Preventiva y Salud Pública2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/115990https://doi.org/10.3390/healthcare9050581reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésHealthcare, 9 (5)https://www.mdpi.com/journal/healthcareinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1159902026-06-17T12:51:07Z
dc.title.none.fl_str_mv Association between anticholinergic burden and constipation: a systematic review
title Association between anticholinergic burden and constipation: a systematic review
spellingShingle Association between anticholinergic burden and constipation: a systematic review
Rodríguez-Ramallo, Héctor
Anticholinergic burden
Anticholinergic scale
Anticholinergic drugs
Constipation
title_short Association between anticholinergic burden and constipation: a systematic review
title_full Association between anticholinergic burden and constipation: a systematic review
title_fullStr Association between anticholinergic burden and constipation: a systematic review
title_full_unstemmed Association between anticholinergic burden and constipation: a systematic review
title_sort Association between anticholinergic burden and constipation: a systematic review
dc.creator.none.fl_str_mv Rodríguez-Ramallo, Héctor
Báez-Gutiérrez, Nerea
Prado-Mel, Elena
Alfaro Lara, Eva Rocío
Santos Ramos, Bernardo
Sánchez Fidalgo, Susana
author Rodríguez-Ramallo, Héctor
author_facet Rodríguez-Ramallo, Héctor
Báez-Gutiérrez, Nerea
Prado-Mel, Elena
Alfaro Lara, Eva Rocío
Santos Ramos, Bernardo
Sánchez Fidalgo, Susana
author_role author
author2 Báez-Gutiérrez, Nerea
Prado-Mel, Elena
Alfaro Lara, Eva Rocío
Santos Ramos, Bernardo
Sánchez Fidalgo, Susana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina Preventiva y Salud Pública
dc.subject.none.fl_str_mv Anticholinergic burden
Anticholinergic scale
Anticholinergic drugs
Constipation
topic Anticholinergic burden
Anticholinergic scale
Anticholinergic drugs
Constipation
description The association between anticholinergic burden and constipation is not well defined and documented; for this reason, a systematic review was carried out in five databases (Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus), including studies assessing the correlation between anticholinergic burden, and constipation between January 2006 and December 2020. Data extraction was conducted independently by two researchers. Abstracts and titles were reviewed to determine eligibility for review with eligible articles read in full. From 2507 identified articles, 11 were selected for this review: six cross-sectional studies, four retrospective cohort studies, and a post hoc analysis of a randomized clinical trial. Overall, nine studies reported at least one statistical association between anticholinergic burden and constipation, finding 13 positive results out of 24 association measurements. A total of 211,921 patients were studied. The association between constipation and anticholinergic burden could be demonstrated in studies including 207,795 patients. Most studies were not designed to find differences in constipation prevalence and did not adjust the results by confounding factors. Our findings suggest that a correlation between anticholinergic burden and constipation exists. Higher quality-evidence studies are needed, including analysis that considers confounding factors, such as other non-pharmacological causes of constipation.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/115990
https://doi.org/10.3390/healthcare9050581
url https://hdl.handle.net/11441/115990
https://doi.org/10.3390/healthcare9050581
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Healthcare, 9 (5)
https://www.mdpi.com/journal/healthcare
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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