Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery

W. K. P. is supported by the Beatriu de Pinós Programme (2023 BP 00247) coordinated by the Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya. S. Q. is financially supported by Japan Science and Technology Agency (JST) funded the open innovation platform for indus...

Full description

Bibliographic Details
Authors: Paraiso, West Kristian, Palacin Ramos, Carlos, Hossain, Parisa Mishal, Álvarez Gordi, Carla, Guillen Poza, Pablo Adrian, Zagmutt, Sebastián, Quader, Sabina, Rodriguez-Rodriguez, Rosalia
Format: article
Publication Date:2025
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/5174
Online Access:http://hdl.handle.net/20.500.12328/5174
https://dx.doi.org/10.1039/d5nr02259b
Access Level:Open access
Keyword:Nanomedicine
Nanomedicina
57
id ES_1085e8ed9a5a3afcf372e6cb39f2fbc7
oai_identifier_str oai:recercat.cat:20.500.12328/5174
network_acronym_str ES
network_name_str España
repository_id_str
spelling Overcoming barriers: nanomedicine-based strategies for nose-to-brain deliveryParaiso, West KristianPalacin Ramos, CarlosHossain, Parisa MishalÁlvarez Gordi, CarlaGuillen Poza, Pablo AdrianZagmutt, SebastiánQuader, SabinaRodriguez-Rodriguez, RosaliaNanomedicineNanomedicina57W. K. P. is supported by the Beatriu de Pinós Programme (2023 BP 00247) coordinated by the Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya. S. Q. is financially supported by Japan Science and Technology Agency (JST) funded the open innovation platform for industry-academia co-creation (COI-NEXT) Program (Grant Number JPMJPF2202). R. R.-R. is supported by the Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación (AEI; PID2023-146716OB-I00) and by AGAUR, Generalitat de Catalunya (Producte, PROD 00094).For therapeutics to reach the brain, the several administration routes available come with some disadvantages, with the primary biological obstacle being the blood–brain barrier (BBB), which is not easy to penetrate despite the sophisticated technologies which have been developed. In addition, reaching specific brain structures invokes additional challenges, entailing more complicated delivery strategies. Nose-to-brain (N2B) delivery or the intranasal (IN) administration route provides a less invasive alternative. With the wealth of knowledge available on N2B delivery of nanomedicines and biotherapeutics, there is an opportunity to synthesize the current literature, especially in terms of promising strategies to improve N2B delivery of nanomedicines, highlighting experimental evaluation and translational challenges. We also emphasized the latest advancements in experimental models for nasal delivery. Aiming to bridge the gap between bench research and clinical application, we reviewed the cases of insulin and oxytocin, two biotherapeutics with high clinical potential for CNS-related diseases, and explore how nanomedicine-based platforms can enhance their effectiveness. This review offers a roadmap for overcoming barriers and accelerating the clinical translation of N2B therapeutics.info:eu-repo/semantics/publishedVersionRoyal Society of Chemistry2025info:eu-repo/semantics/article24http://hdl.handle.net/20.500.12328/5174https://dx.doi.org/10.1039/d5nr02259breponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNanoscale18© The Royal Society of Chemistry 2026https://creativecommons.org/licenses/by-nc/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/51742026-05-29T05:05:01Z
dc.title.none.fl_str_mv Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
title Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
spellingShingle Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
Paraiso, West Kristian
Nanomedicine
Nanomedicina
57
title_short Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
title_full Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
title_fullStr Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
title_full_unstemmed Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
title_sort Overcoming barriers: nanomedicine-based strategies for nose-to-brain delivery
dc.creator.none.fl_str_mv Paraiso, West Kristian
Palacin Ramos, Carlos
Hossain, Parisa Mishal
Álvarez Gordi, Carla
Guillen Poza, Pablo Adrian
Zagmutt, Sebastián
Quader, Sabina
Rodriguez-Rodriguez, Rosalia
author Paraiso, West Kristian
author_facet Paraiso, West Kristian
Palacin Ramos, Carlos
Hossain, Parisa Mishal
Álvarez Gordi, Carla
Guillen Poza, Pablo Adrian
Zagmutt, Sebastián
Quader, Sabina
Rodriguez-Rodriguez, Rosalia
author_role author
author2 Palacin Ramos, Carlos
Hossain, Parisa Mishal
Álvarez Gordi, Carla
Guillen Poza, Pablo Adrian
Zagmutt, Sebastián
Quader, Sabina
Rodriguez-Rodriguez, Rosalia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Nanomedicine
Nanomedicina
57
topic Nanomedicine
Nanomedicina
57
description W. K. P. is supported by the Beatriu de Pinós Programme (2023 BP 00247) coordinated by the Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya. S. Q. is financially supported by Japan Science and Technology Agency (JST) funded the open innovation platform for industry-academia co-creation (COI-NEXT) Program (Grant Number JPMJPF2202). R. R.-R. is supported by the Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación (AEI; PID2023-146716OB-I00) and by AGAUR, Generalitat de Catalunya (Producte, PROD 00094).
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/5174
https://dx.doi.org/10.1039/d5nr02259b
url http://hdl.handle.net/20.500.12328/5174
https://dx.doi.org/10.1039/d5nr02259b
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nanoscale
18
dc.rights.none.fl_str_mv © The Royal Society of Chemistry 2026
https://creativecommons.org/licenses/by-nc/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © The Royal Society of Chemistry 2026
https://creativecommons.org/licenses/by-nc/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 24
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403514667532288
score 15,812429

Similar Items