Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation

Both age-related hearing loss (ARHL) and noise-induced hearing loss (NIHL) may share pathophysiological mechanisms in that they are associated with excess free radical formation and cochlear blood flow reduction, leading to cochlear damage. Therefore, it is possible that short, but repeated exposure...

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Autores: Alvarado Romero, Juan Carlos, Fuentes Santamaría, Verónica, Gabaldón Ull, María Cruz, Juiz Gómez, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/32904
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fnins.2019.00077/full
https://hdl.handle.net/10578/32904
Access Level:acceso abierto
Palabra clave:Auditory brainstem responses
Evoked potentials
Noise-induced hearing loss
Presbycusis
Sensorineural hearing loss
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spelling Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound StimulationAlvarado Romero, Juan CarlosFuentes Santamaría, VerónicaGabaldón Ull, María CruzJuiz Gómez, José ManuelAuditory brainstem responsesEvoked potentialsNoise-induced hearing lossPresbycusisSensorineural hearing lossBoth age-related hearing loss (ARHL) and noise-induced hearing loss (NIHL) may share pathophysiological mechanisms in that they are associated with excess free radical formation and cochlear blood flow reduction, leading to cochlear damage. Therefore, it is possible that short, but repeated exposures to relatively loud noise during extended time periods, like in leisure (i.e., musical devices and concerts) or occupational noise exposures, may add to cochlear aging mechanisms, having an impact on the onset and/or progression of ARHL. Consequently, the aim of the present study was to determine if repeated short-duration overexposure to a long-term noise could accelerate permanent auditory threshold shifts associated with auditory aging in an animal model of ARHL. Toward this goal, young adult, 3-month-old Wistar rats were divided into two groups: one exposed (E) and the other non-exposed (NE) to noise overstimulation. The stimulation protocol consisted of 1 h continuous white noise at 110 dB sound pressure level (SPL), 5 days a week, allowing 2 days for threshold recovery before initiating another stimulation round, until the animals reached an age of 18 months. Auditory brainstem response (ABR) recordings at 0.5, 1, 2, 4, 8, 16, and 32 kHz were performed at 3, 6, 12, and 18 months of age. The results demonstrate that in the E group there were significant increases in auditory thresholds at all tested frequencies starting already at 6 months of age, which extended at 12 and 18 months. However, in NE animals threshold shifts were not evident until 12 months, extending to 18 months of age. Threshold shifts observed in the E animals at 6 and 12 months were significantly larger than those observed in the NE group at the same ages. Threshold shifts at 6 and 12 months in E animals resembled those at 12 and 18 months in NE animals, respectively. This suggests that repeated noise overstimulation in short-duration episodes accelerates the time-course of hearing loss in this animal model of ARHL.Frontiers Media SA202420242019info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.frontiersin.org/articles/10.3389/fnins.2019.00077/fullhttps://hdl.handle.net/10578/32904reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésSAF 2016 78898 C2-1-RFP7-HEALTH-2012-INNOVATON 304925info:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/329042026-05-27T07:36:41Z
dc.title.none.fl_str_mv Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
title Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
spellingShingle Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
Alvarado Romero, Juan Carlos
Auditory brainstem responses
Evoked potentials
Noise-induced hearing loss
Presbycusis
Sensorineural hearing loss
title_short Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
title_full Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
title_fullStr Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
title_full_unstemmed Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
title_sort Age-Related Hearing Loss Is Accelerated by Repeated Short-Duration Loud Sound Stimulation
dc.creator.none.fl_str_mv Alvarado Romero, Juan Carlos
Fuentes Santamaría, Verónica
Gabaldón Ull, María Cruz
Juiz Gómez, José Manuel
author Alvarado Romero, Juan Carlos
author_facet Alvarado Romero, Juan Carlos
Fuentes Santamaría, Verónica
Gabaldón Ull, María Cruz
Juiz Gómez, José Manuel
author_role author
author2 Fuentes Santamaría, Verónica
Gabaldón Ull, María Cruz
Juiz Gómez, José Manuel
author2_role author
author
author
dc.subject.none.fl_str_mv Auditory brainstem responses
Evoked potentials
Noise-induced hearing loss
Presbycusis
Sensorineural hearing loss
topic Auditory brainstem responses
Evoked potentials
Noise-induced hearing loss
Presbycusis
Sensorineural hearing loss
description Both age-related hearing loss (ARHL) and noise-induced hearing loss (NIHL) may share pathophysiological mechanisms in that they are associated with excess free radical formation and cochlear blood flow reduction, leading to cochlear damage. Therefore, it is possible that short, but repeated exposures to relatively loud noise during extended time periods, like in leisure (i.e., musical devices and concerts) or occupational noise exposures, may add to cochlear aging mechanisms, having an impact on the onset and/or progression of ARHL. Consequently, the aim of the present study was to determine if repeated short-duration overexposure to a long-term noise could accelerate permanent auditory threshold shifts associated with auditory aging in an animal model of ARHL. Toward this goal, young adult, 3-month-old Wistar rats were divided into two groups: one exposed (E) and the other non-exposed (NE) to noise overstimulation. The stimulation protocol consisted of 1 h continuous white noise at 110 dB sound pressure level (SPL), 5 days a week, allowing 2 days for threshold recovery before initiating another stimulation round, until the animals reached an age of 18 months. Auditory brainstem response (ABR) recordings at 0.5, 1, 2, 4, 8, 16, and 32 kHz were performed at 3, 6, 12, and 18 months of age. The results demonstrate that in the E group there were significant increases in auditory thresholds at all tested frequencies starting already at 6 months of age, which extended at 12 and 18 months. However, in NE animals threshold shifts were not evident until 12 months, extending to 18 months of age. Threshold shifts observed in the E animals at 6 and 12 months were significantly larger than those observed in the NE group at the same ages. Threshold shifts at 6 and 12 months in E animals resembled those at 12 and 18 months in NE animals, respectively. This suggests that repeated noise overstimulation in short-duration episodes accelerates the time-course of hearing loss in this animal model of ARHL.
publishDate 2019
dc.date.none.fl_str_mv 2019
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.frontiersin.org/articles/10.3389/fnins.2019.00077/full
https://hdl.handle.net/10578/32904
url https://www.frontiersin.org/articles/10.3389/fnins.2019.00077/full
https://hdl.handle.net/10578/32904
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv SAF 2016 78898 C2-1-R
FP7-HEALTH-2012-INNOVATON 304925
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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