Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis

The prevalence of vertebral fractures (VF) and their association with clinical risk factors and outcomes are poorly documented in chronic kidney disease (CKD) cohorts. The aim of the study was to evaluate the prevalence of VF in patients with non-dialysis dependent CKD (NDD-CKD), their value in pred...

Descripción completa

Detalles Bibliográficos
Autores: Castro-Alonso, Cristina|||0000-0002-8363-1953, D'Marco, Luis|||0000-0003-0148-891X, Pomes Tallo, Jaume|||0000-0001-6519-529X, Conill, Montserrat Del Amo, García-Diez, Ana Isabel, Molina, Pablo, Puchades, Mª Jesús|||0000-0001-6927-071X, Valdivielso, José Manuel|||0000-0003-1343-0184, Escudero Quesada, Verónica|||0000-0002-2735-1535, Bover, Jordi|||0000-0003-3577-2273, Navarro-González, Juan F.|||0000-0002-5015-7474, Ribas, Begoña, Pallardo, Luis M., Gorriz, Jose Luis
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283563
Acceso en línea:https://ddd.uab.cat/record/283563
https://dx.doi.org/urn:doi:10.3390/JCM9051604
Access Level:acceso abierto
Palabra clave:Chronic kidney disease
Fractures
Vascular calcification
id ES_0fd3be77bdcefe66fe91d24f39d25cd6
oai_identifier_str oai:ddd.uab.cat:283563
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysisCastro-Alonso, Cristina|||0000-0002-8363-1953D'Marco, Luis|||0000-0003-0148-891XPomes Tallo, Jaume|||0000-0001-6519-529XConill, Montserrat Del AmoGarcía-Diez, Ana IsabelMolina, PabloPuchades, Mª Jesús|||0000-0001-6927-071XValdivielso, José Manuel|||0000-0003-1343-0184Escudero Quesada, Verónica|||0000-0002-2735-1535Bover, Jordi|||0000-0003-3577-2273Navarro-González, Juan F.|||0000-0002-5015-7474Ribas, BegoñaPallardo, Luis M.Gorriz, Jose LuisChronic kidney diseaseFracturesVascular calcificationThe prevalence of vertebral fractures (VF) and their association with clinical risk factors and outcomes are poorly documented in chronic kidney disease (CKD) cohorts. The aim of the study was to evaluate the prevalence of VF in patients with non-dialysis dependent CKD (NDD-CKD), their value in predicting mortality and its correlation with parameters of bone mineral metabolism and vascular calcification. 612 NDD 3-5 stage CKD patients participating in the OSERCE-2 study, a prospective, multicenter, cohort study, were prospectively evaluated and categorized into two groups according to presence or absence of VF at enrollment. VF were assessed with lateral radiographs and Genant semi-quantitative method was applied. Three radiologists specialized in musculoskeletal radiology performed consensual reading of individual images obtained using a Raim DICOM Viewer and a Canon EOS 350 camera to measure with Java Image software in those who had traditional acetate X-ray. Factors related to VF were assessed by logistic regression analysis. Association between VF and death over a 3-year follow-up was assessed by Kaplan-Meier survival curves and Cox-proportional hazard models. VF were detected in 110patients(18%). Serumphosphatelevels(OR0.719,95%CI0.532to0.972,p = 0.032),ankle-brachial index < 0.9 (OR 1.694, 95% CI 1.056-2.717, p = 0.029) and treatment with bisphosphonates (OR 5.636, 95% CI 1.876-16.930, p = 0.002) were independently related to the presence of VF. After a median follow-up of 35 months (IQR: 17-37 months), 62 patients (10%) died. The causes of death were cardiovascular (n = 21, 34%) and infectious (n = 11, 18%). In the crude analysis, fractured patients group had poorer survival (log-rank test, p = 0.02). After multivariate adjustment for age, MDRD, albumin, diabetes mellitus, comorbidity, Adragao Score.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/283563https://dx.doi.org/urn:doi:10.3390/JCM9051604reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2835632026-06-06T12:50:31Z
dc.title.none.fl_str_mv Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
title Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
spellingShingle Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
Castro-Alonso, Cristina|||0000-0002-8363-1953
Chronic kidney disease
Fractures
Vascular calcification
title_short Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
title_full Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
title_fullStr Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
title_full_unstemmed Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
title_sort Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
dc.creator.none.fl_str_mv Castro-Alonso, Cristina|||0000-0002-8363-1953
D'Marco, Luis|||0000-0003-0148-891X
Pomes Tallo, Jaume|||0000-0001-6519-529X
Conill, Montserrat Del Amo
García-Diez, Ana Isabel
Molina, Pablo
Puchades, Mª Jesús|||0000-0001-6927-071X
Valdivielso, José Manuel|||0000-0003-1343-0184
Escudero Quesada, Verónica|||0000-0002-2735-1535
Bover, Jordi|||0000-0003-3577-2273
Navarro-González, Juan F.|||0000-0002-5015-7474
Ribas, Begoña
Pallardo, Luis M.
Gorriz, Jose Luis
author Castro-Alonso, Cristina|||0000-0002-8363-1953
author_facet Castro-Alonso, Cristina|||0000-0002-8363-1953
D'Marco, Luis|||0000-0003-0148-891X
Pomes Tallo, Jaume|||0000-0001-6519-529X
Conill, Montserrat Del Amo
García-Diez, Ana Isabel
Molina, Pablo
Puchades, Mª Jesús|||0000-0001-6927-071X
Valdivielso, José Manuel|||0000-0003-1343-0184
Escudero Quesada, Verónica|||0000-0002-2735-1535
Bover, Jordi|||0000-0003-3577-2273
Navarro-González, Juan F.|||0000-0002-5015-7474
Ribas, Begoña
Pallardo, Luis M.
Gorriz, Jose Luis
author_role author
author2 D'Marco, Luis|||0000-0003-0148-891X
Pomes Tallo, Jaume|||0000-0001-6519-529X
Conill, Montserrat Del Amo
García-Diez, Ana Isabel
Molina, Pablo
Puchades, Mª Jesús|||0000-0001-6927-071X
Valdivielso, José Manuel|||0000-0003-1343-0184
Escudero Quesada, Verónica|||0000-0002-2735-1535
Bover, Jordi|||0000-0003-3577-2273
Navarro-González, Juan F.|||0000-0002-5015-7474
Ribas, Begoña
Pallardo, Luis M.
Gorriz, Jose Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Chronic kidney disease
Fractures
Vascular calcification
topic Chronic kidney disease
Fractures
Vascular calcification
description The prevalence of vertebral fractures (VF) and their association with clinical risk factors and outcomes are poorly documented in chronic kidney disease (CKD) cohorts. The aim of the study was to evaluate the prevalence of VF in patients with non-dialysis dependent CKD (NDD-CKD), their value in predicting mortality and its correlation with parameters of bone mineral metabolism and vascular calcification. 612 NDD 3-5 stage CKD patients participating in the OSERCE-2 study, a prospective, multicenter, cohort study, were prospectively evaluated and categorized into two groups according to presence or absence of VF at enrollment. VF were assessed with lateral radiographs and Genant semi-quantitative method was applied. Three radiologists specialized in musculoskeletal radiology performed consensual reading of individual images obtained using a Raim DICOM Viewer and a Canon EOS 350 camera to measure with Java Image software in those who had traditional acetate X-ray. Factors related to VF were assessed by logistic regression analysis. Association between VF and death over a 3-year follow-up was assessed by Kaplan-Meier survival curves and Cox-proportional hazard models. VF were detected in 110patients(18%). Serumphosphatelevels(OR0.719,95%CI0.532to0.972,p = 0.032),ankle-brachial index < 0.9 (OR 1.694, 95% CI 1.056-2.717, p = 0.029) and treatment with bisphosphonates (OR 5.636, 95% CI 1.876-16.930, p = 0.002) were independently related to the presence of VF. After a median follow-up of 35 months (IQR: 17-37 months), 62 patients (10%) died. The causes of death were cardiovascular (n = 21, 34%) and infectious (n = 11, 18%). In the crude analysis, fractured patients group had poorer survival (log-rank test, p = 0.02). After multivariate adjustment for age, MDRD, albumin, diabetes mellitus, comorbidity, Adragao Score.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/283563
https://dx.doi.org/urn:doi:10.3390/JCM9051604
url https://ddd.uab.cat/record/283563
https://dx.doi.org/urn:doi:10.3390/JCM9051604
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403476024360960
score 15,301603

Similares en LA Referencia