A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration

Bone grafting is one of the most commonly performed treatments for bone healing or repair. Autografts, grafts from the same patient, are the most frequently used bone grafts because they can provide osteogenic cells and growth factors at the site of the implant with reduced risk of rejection or tran...

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Autores: Giordano-Kelhoffer, B., Rodríguez González, Raquel, Perpiñan-Blasco, M., Buitrago, J.O., Bosch, B.M., Perez, R.A.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/20993
Acceso en línea:https://portalcientifico.sergas.gal//documentos/67ce7757e210502b2cf6ef21
http://hdl.handle.net/20.500.11940/20993
Access Level:acceso abierto
Palabra clave:FPGMX
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spelling A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone RegenerationGiordano-Kelhoffer, B.Rodríguez González, RaquelPerpiñan-Blasco, M.Buitrago, J.O.Bosch, B.M.Perez, R.A.FPGMXBone grafting is one of the most commonly performed treatments for bone healing or repair. Autografts, grafts from the same patient, are the most frequently used bone grafts because they can provide osteogenic cells and growth factors at the site of the implant with reduced risk of rejection or transfer of diseases. Nevertheless, this type of graft presents some drawbacks, such as pain, risk of infection, and limited availability. For this reason, synthetic bone grafts are among the main proposals in regenerative medicine. This branch of medicine is based on the development of new biomaterials with the goal of increasing bone healing capacity and, more specifically in dentistry, they aim at simultaneously preventing or eliminating bacterial infections. The use of fibers made of chitosan (CS) and hydroxyapatite (HA) loaded with an antibiotic (doxycycline, DX) and fabricated with the help of an injection pump is presented as a new strategy for improving maxillary bone regeneration. In vitro characterization of the DX controlled released from the fibers was quantified after mixing different amounts of HA (10-75%). The 1% CS concentration was stable, easy to manipulate and exhibited adequate cuttability and pH parameters. The hydroxyapatite concentration dictated the combined fast and controlled release profile of CSHA50DX. Our findings demonstrate that the CS-HA-DX complex may be a promising candidate graft material for enhancing bone tissue regeneration in dental clinical practice.This research was funded by the Government of Catalonia (2021 SGR 708), the Spanish Ministry (Ramon y Cajal fellowship (RYC2018-025977-I) and project RTI2018-096088-J-100 (MINECO/FEDER), and predoctoral fellowship from Universitat Internacional de Catalunya (UIC).2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/67ce7757e210502b2cf6ef21http://hdl.handle.net/20.500.11940/20993reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/209932026-06-12T08:40:47Z
dc.title.none.fl_str_mv A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
title A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
spellingShingle A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
Giordano-Kelhoffer, B.
FPGMX
title_short A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
title_full A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
title_fullStr A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
title_full_unstemmed A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
title_sort A Novel Chitosan Composite Biomaterial with Drug Eluting Capacity for Maxillary Bone Regeneration
dc.creator.none.fl_str_mv Giordano-Kelhoffer, B.
Rodríguez González, Raquel
Perpiñan-Blasco, M.
Buitrago, J.O.
Bosch, B.M.
Perez, R.A.
author Giordano-Kelhoffer, B.
author_facet Giordano-Kelhoffer, B.
Rodríguez González, Raquel
Perpiñan-Blasco, M.
Buitrago, J.O.
Bosch, B.M.
Perez, R.A.
author_role author
author2 Rodríguez González, Raquel
Perpiñan-Blasco, M.
Buitrago, J.O.
Bosch, B.M.
Perez, R.A.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv FPGMX
topic FPGMX
description Bone grafting is one of the most commonly performed treatments for bone healing or repair. Autografts, grafts from the same patient, are the most frequently used bone grafts because they can provide osteogenic cells and growth factors at the site of the implant with reduced risk of rejection or transfer of diseases. Nevertheless, this type of graft presents some drawbacks, such as pain, risk of infection, and limited availability. For this reason, synthetic bone grafts are among the main proposals in regenerative medicine. This branch of medicine is based on the development of new biomaterials with the goal of increasing bone healing capacity and, more specifically in dentistry, they aim at simultaneously preventing or eliminating bacterial infections. The use of fibers made of chitosan (CS) and hydroxyapatite (HA) loaded with an antibiotic (doxycycline, DX) and fabricated with the help of an injection pump is presented as a new strategy for improving maxillary bone regeneration. In vitro characterization of the DX controlled released from the fibers was quantified after mixing different amounts of HA (10-75%). The 1% CS concentration was stable, easy to manipulate and exhibited adequate cuttability and pH parameters. The hydroxyapatite concentration dictated the combined fast and controlled release profile of CSHA50DX. Our findings demonstrate that the CS-HA-DX complex may be a promising candidate graft material for enhancing bone tissue regeneration in dental clinical practice.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/67ce7757e210502b2cf6ef21
http://hdl.handle.net/20.500.11940/20993
url https://portalcientifico.sergas.gal//documentos/67ce7757e210502b2cf6ef21
http://hdl.handle.net/20.500.11940/20993
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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