Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy

© 2021 by the authors.

Detalles Bibliográficos
Autores: Vuelta, Elena, García-Tuñón, Ignacio, Hernández-Carabias, Patricia, Méndez Sánchez, Lucía, Sánchez-Martín, M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/261433
Acceso en línea:http://hdl.handle.net/10261/261433
Access Level:acceso abierto
Palabra clave:CML
CRISPR/Cas9
BCR/ABL1
Genome editing
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spelling Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR TherapyVuelta, ElenaGarcía-Tuñón, IgnacioHernández-Carabias, PatriciaMéndez Sánchez, LucíaSánchez-Martín, M.CMLCRISPR/Cas9BCR/ABL1Genome editing© 2021 by the authors.The constitutively active tyrosine-kinase BCR/ABL1 oncogene plays a key role in human chronic myeloid leukemia development and disease maintenance, and determines most of the features of this leukemia. For this reason, tyrosine-kinase inhibitors are the first-line treatment, offering most patients a life expectancy like that of an equivalent healthy person. However, since the oncogene stays intact, lifelong oral medication is essential, even though this triggers adverse effects in many patients. Furthermore, leukemic stem cells remain quiescent and resistance is observed in approximately 25% of patients. Thus, new therapeutic alternatives are still needed. In this scenario, the interruption/deletion of the oncogenic sequence might be an effective therapeutic option. The emergence of CRISPR (clustered regularly interspaced short palindromic repeats) technology can offer a definitive treatment based on its capacity to induce a specific DNA double strand break. Besides, it has the advantage of providing complete and permanent oncogene knockout, while tyrosine kinase inhibitors (TKIs) only ensure that BCR-ABL1 oncoprotein is inactivated during treatment. CRISPR/Cas9 cuts DNA in a sequence-specific manner making it possible to turn oncogenes off in a way that was not previously feasible in humans. This review describes chronic myeloid leukemia (CML) disease and the main advances in the genome-editing field by which it may be treated in the future.This work was supported by the Instituto de Salud Carlos III (ISCIII), grant number PI17/01895 (ISCIII-FEDER), and by the Fundación Memoria de D. Samuel Solorzano Barroso (FS/29-2020) from the University of Salamanca. E.V. is supported by a predoctoral grant from the University of Salamanca-Banco Santander. P.H.C. and L.M. are supported by Nucleus (platform for research supporting) from the University of Salamanca.Multidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIIFundación Memoria de D. Samuel Solorzano BarrusoUniversidad de SalamancaBanco SantanderConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/261433reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/biology10020118Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2614332026-05-22T06:33:51Z
dc.title.none.fl_str_mv Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
title Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
spellingShingle Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
Vuelta, Elena
CML
CRISPR/Cas9
BCR/ABL1
Genome editing
title_short Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
title_full Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
title_fullStr Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
title_full_unstemmed Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
title_sort Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy
dc.creator.none.fl_str_mv Vuelta, Elena
García-Tuñón, Ignacio
Hernández-Carabias, Patricia
Méndez Sánchez, Lucía
Sánchez-Martín, M.
author Vuelta, Elena
author_facet Vuelta, Elena
García-Tuñón, Ignacio
Hernández-Carabias, Patricia
Méndez Sánchez, Lucía
Sánchez-Martín, M.
author_role author
author2 García-Tuñón, Ignacio
Hernández-Carabias, Patricia
Méndez Sánchez, Lucía
Sánchez-Martín, M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Fundación Memoria de D. Samuel Solorzano Barruso
Universidad de Salamanca
Banco Santander
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv CML
CRISPR/Cas9
BCR/ABL1
Genome editing
topic CML
CRISPR/Cas9
BCR/ABL1
Genome editing
description © 2021 by the authors.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/261433
url http://hdl.handle.net/10261/261433
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/biology10020118
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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