Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort

Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subje...

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Authors: Eguaras, S. (Sonia)|||/items/92c59f57-cac4-4cc1-bc17-bb91f6ae4fa5, Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0, Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189, Cervantes-Ibáñez, S. (Sebastián)|||/items/a961dca3-cb07-4ccb-b2ce-a59eb8652b51, Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Format: article
Publication Date:2015
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/39401
Online Access:https://hdl.handle.net/10171/39401
Access Level:Open access
Keyword:Obesity
Mediterranean diet
Prospective cohort study
Cardiovascular disease
SUN project
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spelling Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohortEguaras, S. (Sonia)|||/items/92c59f57-cac4-4cc1-bc17-bb91f6ae4fa5Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189Cervantes-Ibáñez, S. (Sebastián)|||/items/a961dca3-cb07-4ccb-b2ce-a59eb8652b51Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7ObesityMediterranean dietProspective cohort studyCardiovascular diseaseSUN projectStrong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. We prospectively examined the association between obesity and cardiovascular clinical events (myocardial infarction, stroke or cardiovascular death) after 10.9 years follow-up in 19,065 middle-aged men and women (average age 38 year) according to their adherence to the MedDiet (<6 points or ¥6 points in the Trichopoulou’s Mediterranean Diet Score). We observed 152 incident cases of cardiovascular disease (CVD). An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93–2.25) for ¥25 – <30 kg/m2 of BMI and 2.00 (1.04–3.83) for ¥30 kg/m2 of BMI, compared to a BMI < 25 kg/m2. In contrast, these estimates were 0.77 (0.35–1.67) and 1.15 (0.39–3.43) with good adherence to MedDiet. Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029). Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity.MDPIDadun. Depósito Académico Digital Universidad de Navarra20152015-11-1820152015-01-0120152015-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/39401reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/394012026-06-21T12:47:57Z
dc.title.none.fl_str_mv Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
title Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
spellingShingle Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
Eguaras, S. (Sonia)|||/items/92c59f57-cac4-4cc1-bc17-bb91f6ae4fa5
Obesity
Mediterranean diet
Prospective cohort study
Cardiovascular disease
SUN project
title_short Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
title_full Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
title_fullStr Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
title_full_unstemmed Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
title_sort Better adherence to the mediterranean diet could mitigate the adverse consequences of obesity on cardiovascular disease: The SUN prospective cohort
dc.creator.none.fl_str_mv Eguaras, S. (Sonia)|||/items/92c59f57-cac4-4cc1-bc17-bb91f6ae4fa5
Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189
Cervantes-Ibáñez, S. (Sebastián)|||/items/a961dca3-cb07-4ccb-b2ce-a59eb8652b51
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
author Eguaras, S. (Sonia)|||/items/92c59f57-cac4-4cc1-bc17-bb91f6ae4fa5
author_facet Eguaras, S. (Sonia)|||/items/92c59f57-cac4-4cc1-bc17-bb91f6ae4fa5
Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189
Cervantes-Ibáñez, S. (Sebastián)|||/items/a961dca3-cb07-4ccb-b2ce-a59eb8652b51
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
author_role author
author2 Toledo-Atucha, E. (Estefanía)|||/items/a67de95c-b88e-4c23-8fb9-6482b0f9fba0
Hernandez-Hernandez, A. (Aitor)|||/items/a9dcb96d-265e-4e9b-b5fb-f5a88039c189
Cervantes-Ibáñez, S. (Sebastián)|||/items/a961dca3-cb07-4ccb-b2ce-a59eb8652b51
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Obesity
Mediterranean diet
Prospective cohort study
Cardiovascular disease
SUN project
topic Obesity
Mediterranean diet
Prospective cohort study
Cardiovascular disease
SUN project
description Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. We prospectively examined the association between obesity and cardiovascular clinical events (myocardial infarction, stroke or cardiovascular death) after 10.9 years follow-up in 19,065 middle-aged men and women (average age 38 year) according to their adherence to the MedDiet (<6 points or ¥6 points in the Trichopoulou’s Mediterranean Diet Score). We observed 152 incident cases of cardiovascular disease (CVD). An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93–2.25) for ¥25 – <30 kg/m2 of BMI and 2.00 (1.04–3.83) for ¥30 kg/m2 of BMI, compared to a BMI < 25 kg/m2. In contrast, these estimates were 0.77 (0.35–1.67) and 1.15 (0.39–3.43) with good adherence to MedDiet. Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029). Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-11-18
2015
2015-01-01
2015
2015-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/39401
url https://hdl.handle.net/10171/39401
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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