Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples

Background: At present, 3D printing technology is becoming increasingly popular in analytical chemistry because it enables the rapid and cost-effective manufacture of sample preparation devices, particularly in flow-based operation, opening up new opportunities for the development of automated analy...

Descripción completa

Detalles Bibliográficos
Autores: Díaz-Álvarez, Myriam, Turiel Trujillo, Esther, Martín Esteban, Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/382576
Acceso en línea:http://hdl.handle.net/10261/382576
Access Level:acceso abierto
Palabra clave:3D-printing
Millifluidic device
Natural deep eutectic solvent
Liquid-phase microextraction
Thiabendazole
id ES_0f998b64a5f4b2d0e7a2d0f07b57be0d
oai_identifier_str oai:digital.csic.es:10261/382576
network_acronym_str ES
network_name_str España
repository_id_str
spelling Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samplesDíaz-Álvarez, MyriamTuriel Trujillo, EstherMartín Esteban, Antonio3D-printingMillifluidic deviceNatural deep eutectic solventLiquid-phase microextractionThiabendazoleBackground: At present, 3D printing technology is becoming increasingly popular in analytical chemistry because it enables the rapid and cost-effective manufacture of sample preparation devices, particularly in flow-based operation, opening up new opportunities for the development of automated analytical methods. In parallel, the use of miniaturised methods and sustainable solvents in sample preparation is highly recommended. Accordingly, in this work, a 3D-printed millifluidic device was designed and used for the on-line natural deep eutectic solvent (NADES)-based liquid phase microextraction (LPME) coupled to a spectrofluorometer for, as a proof of concept, the determination of thiabendazole (TBZ) in fruit juice samples. Results: The millifluidic device was 3D printed by stereolithography and consisted of two patterned plates, each containing a millichannel (acceptor and donor channel). The millichannels were separated by a polypropylene membrane impregnated with optimal NADES, acting as a supported liquid membrane (SLM). Among the NADES investigated, formic acid:L-menthol (1:1 molar ratio) was selected as the SLM, avoiding the use of conventional harmful organic solvents. The proposed millifluidic device was successfully applied to the determination of thiabendazole in fruit juice samples, achieving LOD and LOQ values of 0.45 μg.L-1 and 1.42 μg.L-1, respectively, which are well below the maximum residue levels (MRLs) set by the European Union. The greenness and applicability of the proposed analytical method were evaluated using the AGREEPrep, SPMS and BAGI tools and compared with other published methods. In general, the proposed method was superior to others, mainly due to its high sensitivity and high sample throughput. Significance: Several cells were easily designed with different channel geometries (length and depth) to find the optimal dimensions, and then 3D printed and tested in a relatively fast, cheap and simple way, demonstrating the suitability of 3D printing in the fabrication of millifluidic devices as an alternative to traditional fabrication techniques. In addition, the proposed approach is fully compatible with new sustainable solvents, facilitating the development of green sample preparation methods.The Grant PID2021-122327OB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and by “ERDF A way of making Europe” is gratefully acknowledged.Peer reviewedElsevier BVAgencia Estatal de Investigación (España)European CommissionMinisterio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/382576reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122327OB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1016/j.aca.2025.343617https://doi.org/10.1016/j.aca.2025.343617Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3825762026-05-22T06:33:51Z
dc.title.none.fl_str_mv Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
title Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
spellingShingle Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
Díaz-Álvarez, Myriam
3D-printing
Millifluidic device
Natural deep eutectic solvent
Liquid-phase microextraction
Thiabendazole
title_short Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
title_full Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
title_fullStr Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
title_full_unstemmed Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
title_sort Natural deep eutectic solvent-based liquid phase microextraction in a 3D-Printed millifluidic flow cell for the on-line determination of thiabendazole in juice samples
dc.creator.none.fl_str_mv Díaz-Álvarez, Myriam
Turiel Trujillo, Esther
Martín Esteban, Antonio
author Díaz-Álvarez, Myriam
author_facet Díaz-Álvarez, Myriam
Turiel Trujillo, Esther
Martín Esteban, Antonio
author_role author
author2 Turiel Trujillo, Esther
Martín Esteban, Antonio
author2_role author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 3D-printing
Millifluidic device
Natural deep eutectic solvent
Liquid-phase microextraction
Thiabendazole
topic 3D-printing
Millifluidic device
Natural deep eutectic solvent
Liquid-phase microextraction
Thiabendazole
description Background: At present, 3D printing technology is becoming increasingly popular in analytical chemistry because it enables the rapid and cost-effective manufacture of sample preparation devices, particularly in flow-based operation, opening up new opportunities for the development of automated analytical methods. In parallel, the use of miniaturised methods and sustainable solvents in sample preparation is highly recommended. Accordingly, in this work, a 3D-printed millifluidic device was designed and used for the on-line natural deep eutectic solvent (NADES)-based liquid phase microextraction (LPME) coupled to a spectrofluorometer for, as a proof of concept, the determination of thiabendazole (TBZ) in fruit juice samples. Results: The millifluidic device was 3D printed by stereolithography and consisted of two patterned plates, each containing a millichannel (acceptor and donor channel). The millichannels were separated by a polypropylene membrane impregnated with optimal NADES, acting as a supported liquid membrane (SLM). Among the NADES investigated, formic acid:L-menthol (1:1 molar ratio) was selected as the SLM, avoiding the use of conventional harmful organic solvents. The proposed millifluidic device was successfully applied to the determination of thiabendazole in fruit juice samples, achieving LOD and LOQ values of 0.45 μg.L-1 and 1.42 μg.L-1, respectively, which are well below the maximum residue levels (MRLs) set by the European Union. The greenness and applicability of the proposed analytical method were evaluated using the AGREEPrep, SPMS and BAGI tools and compared with other published methods. In general, the proposed method was superior to others, mainly due to its high sensitivity and high sample throughput. Significance: Several cells were easily designed with different channel geometries (length and depth) to find the optimal dimensions, and then 3D printed and tested in a relatively fast, cheap and simple way, demonstrating the suitability of 3D printing in the fabrication of millifluidic devices as an alternative to traditional fabrication techniques. In addition, the proposed approach is fully compatible with new sustainable solvents, facilitating the development of green sample preparation methods.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/382576
url http://hdl.handle.net/10261/382576
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122327OB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1016/j.aca.2025.343617
https://doi.org/10.1016/j.aca.2025.343617
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869403463074447360
score 15,811543

Similares en LA Referencia