Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites

High charge swelling micas are layered silicates used in adsorption of several inorganic and organic species. In this study, we evaluated the adsorption of chlorhexidine digluconate on highly charge mica Na-mica-4. Drug release and antibacterial action against Staphylococcus aureus (S. aureus) and E...

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Autores: Oliveira, Luís H., de Lima, Idglan S., França, Denise B., Moraes, Alan I.S., Fonseca, Maria G., Barreto, Humberto M., Medina Carrasco, Santiago, Osajima, Josy A., da Silva-Filho, Edson C., Orta Cuevas, María del Mar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/156971
Acceso en línea:https://hdl.handle.net/11441/156971
https://doi.org/10.1016/j.clay.2024.107373
Access Level:acceso abierto
Palabra clave:Antibacterial activity
Chlorhexidine digluconate
High charge swelling mica
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spelling Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine NanocompositesOliveira, Luís H.de Lima, Idglan S.França, Denise B.Moraes, Alan I.S.Fonseca, Maria G.Barreto, Humberto M.Medina Carrasco, SantiagoOsajima, Josy A.da Silva-Filho, Edson C.Orta Cuevas, María del MarAntibacterial activityChlorhexidine digluconateHigh charge swelling micaHigh charge swelling micas are layered silicates used in adsorption of several inorganic and organic species. In this study, we evaluated the adsorption of chlorhexidine digluconate on highly charge mica Na-mica-4. Drug release and antibacterial action against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) using the direct contact test for mica/chlorhexidine hybrids were evaluated. The hybrids were characterized using X-ray diffraction, Fourier transform infrared spectroscopy, zeta potential measurements, CHN elemental analysis, and scanning electron microscopy. Chlorhexidine interacts successfully with the mica surface. The maximum amount of chlorhexidine incorporated was 583 mg g−1, and the characterizations indicated that electrostatic attraction between the protonated amino group of the drug and the negative surface of clay was predominant in the formation of hybrids. Release kinetics study indicated that 80% of the drug release occurred in the first 12 h. The antibacterial test proved to be dependent on the time of chlorhexidine release, reaching 100% inhibition against S. aureus and E. coli after 0.5 h and 6 h, respectively.Universidad de Sevilla 2022/00000444Gobierno de España 2023/00000313ElsevierQuímica AnalíticaUniversidad de SevillaGobierno de España2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/156971https://doi.org/10.1016/j.clay.2024.107373reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésApplied Clay Science, 254, 107373.2022/000004442023/00000313https://doi.org/10.1016/j.clay.2024.107373info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1569712026-06-17T12:51:07Z
dc.title.none.fl_str_mv Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
title Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
spellingShingle Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
Oliveira, Luís H.
Antibacterial activity
Chlorhexidine digluconate
High charge swelling mica
title_short Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
title_full Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
title_fullStr Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
title_full_unstemmed Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
title_sort Preparation and Release of Antibacterial Na-mica-4/Chlorhexidine Nanocomposites
dc.creator.none.fl_str_mv Oliveira, Luís H.
de Lima, Idglan S.
França, Denise B.
Moraes, Alan I.S.
Fonseca, Maria G.
Barreto, Humberto M.
Medina Carrasco, Santiago
Osajima, Josy A.
da Silva-Filho, Edson C.
Orta Cuevas, María del Mar
author Oliveira, Luís H.
author_facet Oliveira, Luís H.
de Lima, Idglan S.
França, Denise B.
Moraes, Alan I.S.
Fonseca, Maria G.
Barreto, Humberto M.
Medina Carrasco, Santiago
Osajima, Josy A.
da Silva-Filho, Edson C.
Orta Cuevas, María del Mar
author_role author
author2 de Lima, Idglan S.
França, Denise B.
Moraes, Alan I.S.
Fonseca, Maria G.
Barreto, Humberto M.
Medina Carrasco, Santiago
Osajima, Josy A.
da Silva-Filho, Edson C.
Orta Cuevas, María del Mar
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Química Analítica
Universidad de Sevilla
Gobierno de España
dc.subject.none.fl_str_mv Antibacterial activity
Chlorhexidine digluconate
High charge swelling mica
topic Antibacterial activity
Chlorhexidine digluconate
High charge swelling mica
description High charge swelling micas are layered silicates used in adsorption of several inorganic and organic species. In this study, we evaluated the adsorption of chlorhexidine digluconate on highly charge mica Na-mica-4. Drug release and antibacterial action against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) using the direct contact test for mica/chlorhexidine hybrids were evaluated. The hybrids were characterized using X-ray diffraction, Fourier transform infrared spectroscopy, zeta potential measurements, CHN elemental analysis, and scanning electron microscopy. Chlorhexidine interacts successfully with the mica surface. The maximum amount of chlorhexidine incorporated was 583 mg g−1, and the characterizations indicated that electrostatic attraction between the protonated amino group of the drug and the negative surface of clay was predominant in the formation of hybrids. Release kinetics study indicated that 80% of the drug release occurred in the first 12 h. The antibacterial test proved to be dependent on the time of chlorhexidine release, reaching 100% inhibition against S. aureus and E. coli after 0.5 h and 6 h, respectively.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/156971
https://doi.org/10.1016/j.clay.2024.107373
url https://hdl.handle.net/11441/156971
https://doi.org/10.1016/j.clay.2024.107373
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Applied Clay Science, 254, 107373.
2022/00000444
2023/00000313
https://doi.org/10.1016/j.clay.2024.107373
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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