Funcionalización periférica de dendrímeros rígidos de tetrafenilmetano
In this thesis new shape-persistent dendrimers with tetraphenylmethane nodes, ethynylene linkers and terminal ester groups have been developed. Its synthesis was accomplished following a convergent route, and they have been characterized by NMR, MS and SEC. In addition, its optical properties have b...
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| Tipo de documento: | tese |
| Data de publicação: | 2020 |
| País: | España |
| Recursos: | Universidad de Santiago de Compostela (USC) |
| Repositório: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | espanhol |
| OAI Identifier: | oai:minerva.usc.gal:10347/20865 |
| Acesso em linha: | http://hdl.handle.net/10347/20865 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Materias::Investigación::23 Química::2304 Química macromolecular::230408 Macromoléculas Materias::Investigación::23 Química::2304 Química macromolecular::230423 Síntesis de macromoléculas |
| Resumo: | In this thesis new shape-persistent dendrimers with tetraphenylmethane nodes, ethynylene linkers and terminal ester groups have been developed. Its synthesis was accomplished following a convergent route, and they have been characterized by NMR, MS and SEC. In addition, its optical properties have been evaluated, as they show high intrinsic fluorescence. Its periphery offers numerous functionalization possibilities, so its biocompatibility could be significantly increased. This, together with its globular structure and the presence of well-defined hydrophobic internal cavities make them good candidates for possible future applications in biomedicine. En esta tesis se han desarrollado nuevos dendrímeros con forma persistente basados en unidades de tetrafenilmetano con conectores etinileno y grupos éster terminales. Los dendrímeros se han sintetizado mediante una estrategia convergente y se han caracterizado mediante RMN, EM y SEC. Además, se han estudiado sus propiedades ópticas, pues poseen una elevada fluorescencia intrínseca. Su periferia ofrece numerosas posibilidades de funcionalización, por lo que se podría aumentar considerablemente su biocompatibilidad. Esto junto con su estructura globular y la presencia de cavidades internas hidrófobas bien definidas hacen que sean buenos candidatos a posibles futuras aplicaciones en biomedicina. |
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