Replication data for The arginine repressor ArgR controls virulence factors of Adherent-Invasive Escherichia coli strains
This dataset contains RNA‑sequencing data generated to investigate the regulatory role of the arginine repressor ArgR in Escherichia coli, with a focus on Adherent‑Invasive E. coli (AIEC), a pathotype associated with Crohn’s disease. Transcriptomes were obtained from four E. coli backgrounds—AIEC16,...
| Autores: | , , |
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| Tipo de documento: | conjunto de datos |
| Data de publicação: | 2026 |
| País: | España |
| Recursos: | Consorci de Serveis Universitaris de Catalunya (CSUC) |
| Repositório: | CORA.Repositori de Dades de Recerca |
| OAI Identifier: | oai:dnet:cora.rdr____::6cfb0e7404ac374f8209cce187ee0e84 |
| Acesso em linha: | https://doi.org/10.34810/DATA3287 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Medicine, Health and Life Sciences Adherent Invasive Escherichia coli Escherichia coli Escheríchia coli Arginine Arginine biosynthesis Arginina -- Síntesi Arginina -- Síntesis Virulence regulation Crohn's disease Enteritis regional Crohn, Malaltia de |
| Resumo: | This dataset contains RNA‑sequencing data generated to investigate the regulatory role of the arginine repressor ArgR in Escherichia coli, with a focus on Adherent‑Invasive E. coli (AIEC), a pathotype associated with Crohn’s disease. Transcriptomes were obtained from four E. coli backgrounds—AIEC16, LF82, Nissle 1917, and K‑12 C600—in both wild‑type (WT) and ΔargR mutant strains. Deletion of argR leads to constitutive upregulation of arginine biosynthesis genes, and this dataset supports comparative transcriptomic analyses aimed at identifying ArgR‑dependent regulatory networks. Differential expression analysis revealed that ArgR influences multiple virulence‑associated pathways in AIEC strains, including motility, invasion, biofilm formation, acid resistance, adhesion, lipopolysaccharide biosynthesis, and iron uptake. These RNA‑seq data provide a resource for exploring ArgR‑mediated transcriptional regulation and its contribution to AIEC pathogenicity. |
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