Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence

BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based bir...

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Detalles Bibliográficos
Autores: Wickman, Magnus, Lupinek, Christian, Andersson, Niklas, Belgrave, Danielle, Asarnoj, Anna, Benet, Marta, Pinart, Mariona, Wieser, Sandra, García Aymerich, Judith, Baar, Alexandra, Pershagen, Göran, Simpson, Angela, Kull, Inger, Bergström, Anna, Melén, Erik, Hamsten, Carl, Antó i Boqué, Josep Maria, Bousquet, Jean, Custovic, Adnan, Valenta, Rudolf, van Hage, Marianne
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/34026
Acceso en línea:http://hdl.handle.net/10230/34026
http://dx.doi.org/10.1016/j.ebiom.2017.11.009
Access Level:acceso abierto
Palabra clave:Asthma
IgE
Rhinitis
Sensitisation
Prediction
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spelling Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescenceWickman, MagnusLupinek, ChristianAndersson, NiklasBelgrave, DanielleAsarnoj, AnnaBenet, MartaPinart, MarionaWieser, SandraGarcía Aymerich, JudithBaar, AlexandraPershagen, GöranSimpson, AngelaKull, IngerBergström, AnnaMelén, ErikHamsten, CarlAntó i Boqué, Josep MariaBousquet, JeanCustovic, AdnanValenta, Rudolfvan Hage, MarianneAsthmaIgERhinitisSensitisationPredictionBACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11years (N=248) and the outcome was studied at 11years. FINDINGS: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16years were 100% and 100%, respectively, for IgE reactivity to ≥3 of 5 risk molecules. INTERPRETATIONS: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.This study was supported by research grants from the Swedish Asthma and Allergy Foundation, Stockholm County Council (ALF Medicin), Swedish Research Council, the Swedish Heart-Lung Foundation, the Swedish Cancer and Allergy Foundation, the King Gustaf V 80th Birthday Foundation, the Hesselman Foundation, The Konsul Th C Bergh Foundation, the Magnus Bergvall Foundation, Working Life and Welfare, grant F4605 of the Austrian Science Fund (FWF) and by the European Commission's Seventh Framework 29 Program MeDALL under grant agreement No. 261357. Danielle Belgrave is supported through the Medical Research Council Grant MR/M015181/1Elsevier201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/34026http://dx.doi.org/10.1016/j.ebiom.2017.11.009reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEBioMedicine. 2017 Dec;26:91-9info:eu-repo/grantAgreement/EC/FP7/261357Copyright © 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/340262026-05-29T05:05:01Z
dc.title.none.fl_str_mv Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
title Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
spellingShingle Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
Wickman, Magnus
Asthma
IgE
Rhinitis
Sensitisation
Prediction
title_short Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
title_full Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
title_fullStr Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
title_full_unstemmed Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
title_sort Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
dc.creator.none.fl_str_mv Wickman, Magnus
Lupinek, Christian
Andersson, Niklas
Belgrave, Danielle
Asarnoj, Anna
Benet, Marta
Pinart, Mariona
Wieser, Sandra
García Aymerich, Judith
Baar, Alexandra
Pershagen, Göran
Simpson, Angela
Kull, Inger
Bergström, Anna
Melén, Erik
Hamsten, Carl
Antó i Boqué, Josep Maria
Bousquet, Jean
Custovic, Adnan
Valenta, Rudolf
van Hage, Marianne
author Wickman, Magnus
author_facet Wickman, Magnus
Lupinek, Christian
Andersson, Niklas
Belgrave, Danielle
Asarnoj, Anna
Benet, Marta
Pinart, Mariona
Wieser, Sandra
García Aymerich, Judith
Baar, Alexandra
Pershagen, Göran
Simpson, Angela
Kull, Inger
Bergström, Anna
Melén, Erik
Hamsten, Carl
Antó i Boqué, Josep Maria
Bousquet, Jean
Custovic, Adnan
Valenta, Rudolf
van Hage, Marianne
author_role author
author2 Lupinek, Christian
Andersson, Niklas
Belgrave, Danielle
Asarnoj, Anna
Benet, Marta
Pinart, Mariona
Wieser, Sandra
García Aymerich, Judith
Baar, Alexandra
Pershagen, Göran
Simpson, Angela
Kull, Inger
Bergström, Anna
Melén, Erik
Hamsten, Carl
Antó i Boqué, Josep Maria
Bousquet, Jean
Custovic, Adnan
Valenta, Rudolf
van Hage, Marianne
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Asthma
IgE
Rhinitis
Sensitisation
Prediction
topic Asthma
IgE
Rhinitis
Sensitisation
Prediction
description BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11years (N=248) and the outcome was studied at 11years. FINDINGS: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16years were 100% and 100%, respectively, for IgE reactivity to ≥3 of 5 risk molecules. INTERPRETATIONS: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/34026
http://dx.doi.org/10.1016/j.ebiom.2017.11.009
url http://hdl.handle.net/10230/34026
http://dx.doi.org/10.1016/j.ebiom.2017.11.009
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv EBioMedicine. 2017 Dec;26:91-9
info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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