Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats

A considerable number of epidemiological investigations and intervention studies have supported an association between the intake of flavanol- and proanthocyanidin-containing foods and a decreased risk of metabolic diseases. Nonetheless, less is know about the capacity of tissues to accumulate flava...

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Authors: Serra Maqueda, Aida, Bladé, Cinta, Arola i Ferrer, Lluís, Macià i Puig, Ma Alba, Motilva Casado, Mª José
Format: article
Status:Published version
Publication Date:2013
Country:España
Institution:Universitat de Lleida (UdL)
Repository:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/64827
Online Access:https://doi.org/10.1017/S0007114513000706
http://hdl.handle.net/10459.1/64827
Access Level:Open access
Keyword:Flavanols
Long-term intake
Tissue distribution
Adipose tissue
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spelling Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in ratsSerra Maqueda, AidaBladé, CintaArola i Ferrer, LluísMacià i Puig, Ma AlbaMotilva Casado, Mª JoséFlavanolsLong-term intakeTissue distributionAdipose tissueA considerable number of epidemiological investigations and intervention studies have supported an association between the intake of flavanol- and proanthocyanidin-containing foods and a decreased risk of metabolic diseases. Nonetheless, less is know about the capacity of tissues to accumulate flavanols and/or their metabolites. The main objective of the present study was to determine (n 20) plasma bioavailability and disposition in the liver, muscle, brown adipose tissue (BAT) and white adipose tissues (mesenteric and perirenal) in rats after a long-term consumption of three doses of grape seed phenolic extract (5, 25 and 50 mg/kg body weight) for 21 d in order to determine whether there is a dose–response relationship. Glucuronidated conjugates (total glucuronidated conjugates: C5 mg/kg 1·9; C25 mg/kg 6·4; C50 mg/kg 27·7mmol/l plasma) followed by methyl glucuronidated conjugates (total methyl glucuronidated conjugates: C5 mg/kg 1·98; C25 mg/kg 4·48; C50 mg/kg 12·5mmol/l plasma) were the main flavanol metabolites quantified in plasma, also detecting a dimer in its free form (C25 mg/kg 0·74; C50 mg/kg 0·79mmol/l plasma). Each of the studied organs has a particular behaviour of accumulation and response to the assayed grape seed extract doses, with an exponential bioavailability–dose relationship in BAT, in which flavanols could play an important role in the reduction or prevention of obesity, modulating the functionality of that tissue.The present study was supported by grant no. AGL 2008- 00387/ALI and AGL2009-13517-C03-02 from the Spanish Government. It was also supported by the Catalan Government (Interdepartmental Commission for Research and Technological Innovation) through the A. Serra grant.Cambridge University Press2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1017/S0007114513000706http://hdl.handle.net/10459.1/64827reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésMICINN/PN2008-2011/AGL2008-00387/ALIMICINN/PN2008-2011/AGL2009-13517-C03-02Reproducció del document publicat a https://doi.org/10.1017/S0007114513000706British Journal of Nutrition, 2013, vol. 110, núm. 8, p. 1411-1420(c) Cambridge University Press, 2013info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/648272026-06-24T12:42:17Z
dc.title.none.fl_str_mv Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
title Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
spellingShingle Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
Serra Maqueda, Aida
Flavanols
Long-term intake
Tissue distribution
Adipose tissue
title_short Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
title_full Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
title_fullStr Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
title_full_unstemmed Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
title_sort Flavanol metabolites distribute in visceral adipose depots after a long-term intake of grape seed proanthocyanidin extract in rats
dc.creator.none.fl_str_mv Serra Maqueda, Aida
Bladé, Cinta
Arola i Ferrer, Lluís
Macià i Puig, Ma Alba
Motilva Casado, Mª José
author Serra Maqueda, Aida
author_facet Serra Maqueda, Aida
Bladé, Cinta
Arola i Ferrer, Lluís
Macià i Puig, Ma Alba
Motilva Casado, Mª José
author_role author
author2 Bladé, Cinta
Arola i Ferrer, Lluís
Macià i Puig, Ma Alba
Motilva Casado, Mª José
author2_role author
author
author
author
dc.subject.none.fl_str_mv Flavanols
Long-term intake
Tissue distribution
Adipose tissue
topic Flavanols
Long-term intake
Tissue distribution
Adipose tissue
description A considerable number of epidemiological investigations and intervention studies have supported an association between the intake of flavanol- and proanthocyanidin-containing foods and a decreased risk of metabolic diseases. Nonetheless, less is know about the capacity of tissues to accumulate flavanols and/or their metabolites. The main objective of the present study was to determine (n 20) plasma bioavailability and disposition in the liver, muscle, brown adipose tissue (BAT) and white adipose tissues (mesenteric and perirenal) in rats after a long-term consumption of three doses of grape seed phenolic extract (5, 25 and 50 mg/kg body weight) for 21 d in order to determine whether there is a dose–response relationship. Glucuronidated conjugates (total glucuronidated conjugates: C5 mg/kg 1·9; C25 mg/kg 6·4; C50 mg/kg 27·7mmol/l plasma) followed by methyl glucuronidated conjugates (total methyl glucuronidated conjugates: C5 mg/kg 1·98; C25 mg/kg 4·48; C50 mg/kg 12·5mmol/l plasma) were the main flavanol metabolites quantified in plasma, also detecting a dimer in its free form (C25 mg/kg 0·74; C50 mg/kg 0·79mmol/l plasma). Each of the studied organs has a particular behaviour of accumulation and response to the assayed grape seed extract doses, with an exponential bioavailability–dose relationship in BAT, in which flavanols could play an important role in the reduction or prevention of obesity, modulating the functionality of that tissue.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1017/S0007114513000706
http://hdl.handle.net/10459.1/64827
url https://doi.org/10.1017/S0007114513000706
http://hdl.handle.net/10459.1/64827
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv MICINN/PN2008-2011/AGL2008-00387/ALI
MICINN/PN2008-2011/AGL2009-13517-C03-02
Reproducció del document publicat a https://doi.org/10.1017/S0007114513000706
British Journal of Nutrition, 2013, vol. 110, núm. 8, p. 1411-1420
dc.rights.none.fl_str_mv (c) Cambridge University Press, 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Cambridge University Press, 2013
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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