A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect

Recommendations towards increased consumption of fresh fruit and vegetables are well supported by epidemiological and clinical trials. However, in some specific cases, it is difficult to follow these recommendations and the use of nutraceuticals or, in the present work, a freezedried fruits mixture...

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Detalles Bibliográficos
Autores: Carballeda-Sangiao, Noelia, Chamorro Francisco, Susana, Pascual-Teresa, Sonia de
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8668
Acceso en línea:https://hdl.handle.net/20.500.14352/8668
Access Level:acceso abierto
Palabra clave:612.8
613.2
Polyphenol
Anthocyanin
Neuronal
Antioxidant
Red-berry
Neurociencias (Biológicas)
2490 Neurociencias
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oai_identifier_str oai:docta.ucm.es:20.500.14352/8668
network_acronym_str ES
network_name_str España
repository_id_str
spelling A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effectCarballeda-Sangiao, NoeliaChamorro Francisco, SusanaPascual-Teresa, Sonia de612.8613.2PolyphenolAnthocyaninNeuronalAntioxidantRed-berryNeurociencias (Biológicas)2490 NeurocienciasRecommendations towards increased consumption of fresh fruit and vegetables are well supported by epidemiological and clinical trials. However, in some specific cases, it is difficult to follow these recommendations and the use of nutraceuticals or, in the present work, a freezedried fruits mixture can be recommended in order to afford the optimal consumption of dietary polyphenols naturally present in fruits and vegetables. In this work we have carefully characterized a red-berry mixture in terms of polyphenol composition, encountering mainly anthocyanins, which account for a total of 2.8 mg/g as cyanidin-3-glucoside equivalents. Additionally, we have assayed the red-berry blend in a cell model of neurological damage by differentiating the cells and measuring the effect of red-berry polyphenols on cell viability and redox state by flow cytometry. The berry-fruit extract showed an inhibitory effect on differentiated SH-SY5Y ROS formation at a concentration as low as 250 µg/mL (33% inhibition). The results show the potential of this berry-fruit blend for its nutraceutical use in the prevention of the neurodegeneration associated with age or environmental agents.MDPIUniversidad Complutense de Madrid20212021-05-2720212021-05-27journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8668reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/86682026-06-02T12:44:21Z
dc.title.none.fl_str_mv A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
title A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
spellingShingle A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
Carballeda-Sangiao, Noelia
612.8
613.2
Polyphenol
Anthocyanin
Neuronal
Antioxidant
Red-berry
Neurociencias (Biológicas)
2490 Neurociencias
title_short A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
title_full A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
title_fullStr A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
title_full_unstemmed A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
title_sort A Red-Berry mixture as a Nutraceutical: detailed composition and neuronal protective effect
dc.creator.none.fl_str_mv Carballeda-Sangiao, Noelia
Chamorro Francisco, Susana
Pascual-Teresa, Sonia de
author Carballeda-Sangiao, Noelia
author_facet Carballeda-Sangiao, Noelia
Chamorro Francisco, Susana
Pascual-Teresa, Sonia de
author_role author
author2 Chamorro Francisco, Susana
Pascual-Teresa, Sonia de
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.8
613.2
Polyphenol
Anthocyanin
Neuronal
Antioxidant
Red-berry
Neurociencias (Biológicas)
2490 Neurociencias
topic 612.8
613.2
Polyphenol
Anthocyanin
Neuronal
Antioxidant
Red-berry
Neurociencias (Biológicas)
2490 Neurociencias
description Recommendations towards increased consumption of fresh fruit and vegetables are well supported by epidemiological and clinical trials. However, in some specific cases, it is difficult to follow these recommendations and the use of nutraceuticals or, in the present work, a freezedried fruits mixture can be recommended in order to afford the optimal consumption of dietary polyphenols naturally present in fruits and vegetables. In this work we have carefully characterized a red-berry mixture in terms of polyphenol composition, encountering mainly anthocyanins, which account for a total of 2.8 mg/g as cyanidin-3-glucoside equivalents. Additionally, we have assayed the red-berry blend in a cell model of neurological damage by differentiating the cells and measuring the effect of red-berry polyphenols on cell viability and redox state by flow cytometry. The berry-fruit extract showed an inhibitory effect on differentiated SH-SY5Y ROS formation at a concentration as low as 250 µg/mL (33% inhibition). The results show the potential of this berry-fruit blend for its nutraceutical use in the prevention of the neurodegeneration associated with age or environmental agents.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-05-27
2021
2021-05-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8668
url https://hdl.handle.net/20.500.14352/8668
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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