Living on the edge: stress and activation of stress responses promote lifespan extension

Oxidative stress constitutes the basis of physio-pathological situations such as neurodegenerative diseases and aging. However, sublethal exposure to toxic molecules such as reactive oxygen species can induce cellular responses that result in stress fitness. Studies in Schizosaccharomyces pombe have...

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Detalles Bibliográficos
Autores: Zuin, Alice, 1978-, Castellano Esteve, David, Ayté del Olmo, José, Hidalgo Hernando, Elena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/23632
Acceso en línea:http://hdl.handle.net/10230/23632
http://dx.doi.org/10.18632/aging.100133
Access Level:acceso abierto
Palabra clave:Cèl·lules -- Envelliment
Estrès oxidatiu
Proteïnes quinases
MAP kinase
Aging
Oxidative stress
Protein kinase A
Sty1
Sck2
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spelling Living on the edge: stress and activation of stress responses promote lifespan extensionZuin, Alice, 1978-Castellano Esteve, DavidAyté del Olmo, JoséHidalgo Hernando, ElenaCèl·lules -- EnvellimentEstrès oxidatiuProteïnes quinasesMAP kinaseAgingOxidative stressProtein kinase ASty1Sck2Oxidative stress constitutes the basis of physio-pathological situations such as neurodegenerative diseases and aging. However, sublethal exposure to toxic molecules such as reactive oxygen species can induce cellular responses that result in stress fitness. Studies in Schizosaccharomyces pombe have recently showed that the Sty1 MAP kinase, known to be activated by hydrogen peroxide and other cellular stressors, plays a pivotal role in promoting fitness and longevity when it becomes activated by calorie restriction, a situation which induces oxidative metabolism and reactive oxygen species production. Activation of the MAP kinase by calorie restriction during logarithmic growth induces a transcriptional anti-stress response including genes essential to promote lifespan extension. Importantly enough, the lifespan promotion exerted by deletion of the pka1 or sck2 genes, inactivating the two main nutrient-responsive pathways, is dependent on the presence of a functional Sty1 stress pathway, since double mutants also lacking Sty1 or its main substrate Atf1 do not display extended viability. In this Research Perspective, we review these findings in relation to previous reports and extend important aspects of the original study. We propose that moderate stress levels that are not harmful for cells can make them stronger.This work was supported by Dirección General de Investigación of Spain Grants BFU2006-02610 and BFU2009-06933, Plan E and FEDER, and by the Spanish program Consolider-Ingenio 2010 Grant /nCSD 2007-0020 to E.HImpact Journals201520152010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/23632http://dx.doi.org/10.18632/aging.100133reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAging. 2010;2(4):231-37info:eu-repo/grantAgreement/ES/2PN/BFU2006-02610info:eu-repo/grantAgreement/ES/2PN/CSD2007-0020info:eu-repo/grantAgreement/ES/3PN/BFU2009-06933© Zuin et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/236322026-05-29T05:05:01Z
dc.title.none.fl_str_mv Living on the edge: stress and activation of stress responses promote lifespan extension
title Living on the edge: stress and activation of stress responses promote lifespan extension
spellingShingle Living on the edge: stress and activation of stress responses promote lifespan extension
Zuin, Alice, 1978-
Cèl·lules -- Envelliment
Estrès oxidatiu
Proteïnes quinases
MAP kinase
Aging
Oxidative stress
Protein kinase A
Sty1
Sck2
title_short Living on the edge: stress and activation of stress responses promote lifespan extension
title_full Living on the edge: stress and activation of stress responses promote lifespan extension
title_fullStr Living on the edge: stress and activation of stress responses promote lifespan extension
title_full_unstemmed Living on the edge: stress and activation of stress responses promote lifespan extension
title_sort Living on the edge: stress and activation of stress responses promote lifespan extension
dc.creator.none.fl_str_mv Zuin, Alice, 1978-
Castellano Esteve, David
Ayté del Olmo, José
Hidalgo Hernando, Elena
author Zuin, Alice, 1978-
author_facet Zuin, Alice, 1978-
Castellano Esteve, David
Ayté del Olmo, José
Hidalgo Hernando, Elena
author_role author
author2 Castellano Esteve, David
Ayté del Olmo, José
Hidalgo Hernando, Elena
author2_role author
author
author
dc.subject.none.fl_str_mv Cèl·lules -- Envelliment
Estrès oxidatiu
Proteïnes quinases
MAP kinase
Aging
Oxidative stress
Protein kinase A
Sty1
Sck2
topic Cèl·lules -- Envelliment
Estrès oxidatiu
Proteïnes quinases
MAP kinase
Aging
Oxidative stress
Protein kinase A
Sty1
Sck2
description Oxidative stress constitutes the basis of physio-pathological situations such as neurodegenerative diseases and aging. However, sublethal exposure to toxic molecules such as reactive oxygen species can induce cellular responses that result in stress fitness. Studies in Schizosaccharomyces pombe have recently showed that the Sty1 MAP kinase, known to be activated by hydrogen peroxide and other cellular stressors, plays a pivotal role in promoting fitness and longevity when it becomes activated by calorie restriction, a situation which induces oxidative metabolism and reactive oxygen species production. Activation of the MAP kinase by calorie restriction during logarithmic growth induces a transcriptional anti-stress response including genes essential to promote lifespan extension. Importantly enough, the lifespan promotion exerted by deletion of the pka1 or sck2 genes, inactivating the two main nutrient-responsive pathways, is dependent on the presence of a functional Sty1 stress pathway, since double mutants also lacking Sty1 or its main substrate Atf1 do not display extended viability. In this Research Perspective, we review these findings in relation to previous reports and extend important aspects of the original study. We propose that moderate stress levels that are not harmful for cells can make them stronger.
publishDate 2010
dc.date.none.fl_str_mv 2010
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/23632
http://dx.doi.org/10.18632/aging.100133
url http://hdl.handle.net/10230/23632
http://dx.doi.org/10.18632/aging.100133
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Aging. 2010;2(4):231-37
info:eu-repo/grantAgreement/ES/2PN/BFU2006-02610
info:eu-repo/grantAgreement/ES/2PN/CSD2007-0020
info:eu-repo/grantAgreement/ES/3PN/BFU2009-06933
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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