Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer
To evaluate whether computed tomography (CT) scans should be performed before or after transurethral resection of bladder tumour (TURBT) for accurate lymph node staging in clinically lymph node-positive bladder cancer (BCa). Additionally, to identify patient factors that can aid in predicting lymph...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:uabarcelona_::c36b6aa5d335654f02dfbc699ff7f8d2 |
| Acceso en línea: | https://ddd.uab.cat/record/328188 https://dx.doi.org/urn:doi:10.1111/bju.16851 |
| Access Level: | acceso abierto |
| Palabra clave: | cN+ Lymph node staging Computed tomography Radical cystectomy Template Urinary bladder neoplasms Urothelial cancer |
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Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancervon Deimling, Markus|||0000-0002-9954-3413Furrer, Marc|||0000-0001-8847-6799Pichler, Renate|||0000-0001-5286-9048Maas, MoritzTully, Karl Heinrich|||0000-0002-9499-0169Mertens, Laura S.|||0000-0003-3317-6427Taylor, JacobDel Giudice, Francesco|||0000-0003-3865-5988Li, Roger|||0000-0003-1274-7200Gallioli, Andrea|||0000-0002-3316-5691Albisinni, Simone|||0000-0001-5529-3064Crocetto, Felice|||0000-0002-4315-7660Velev, MaudAfferi, Luca|||0000-0002-5472-1933Mari, Andrea|||0000-0001-9070-5706Laukhtina, Ekaterina|||0000-0002-8953-0272Fisch, MargitSpiess, Philippe E.Lotan, Yair|||0000-0001-5692-2723Moschini, Marco|||0000-0002-3084-2458Black, Peter C.Antonelli, Alessandro|||0000-0002-7455-8803Kiss, Bernhard|||0000-0002-4691-556XShariat, Shahrokh|||0000-0002-6627-6179Pradere, Benjamin|||0000-0002-7768-8558Bianchi, AlbertoLongoni, MattiaKlemm, JakobSingla, NirmishcN+Lymph node stagingComputed tomographyRadical cystectomyTemplateUrinary bladder neoplasmsUrothelial cancerTo evaluate whether computed tomography (CT) scans should be performed before or after transurethral resection of bladder tumour (TURBT) for accurate lymph node staging in clinically lymph node-positive bladder cancer (BCa). Additionally, to identify patient factors that can aid in predicting lymph node metastasis. In this retrospective, multicentre study, we analysed patients with cN+ M0 BCa staged by CT and treated with upfront radical cystectomy (RC) and pelvic lymph node dissection. We stratified patients by the interval between TURBT and CT into three groups: (1) before TURBT; (2) within 30 days after TURBT; and (3) more than 30 days post-TURBT. Staging accuracy, defined as concordance between clinical and pathological lymph node status, was evaluated. We utilised logistic regression analyses to identify patient factors, including the optimal timing of staging, in predicting pathological lymph node status at RC. Among 183 patients with cN+ disease, 90 (49%) had pN0 disease at RC. Of these, 40, 36 and 14 were staged before TURBT, within 30 days after TURBT, and more than 30 days post-TURBT, respectively (P = 0.2). Pathological downstaging was most common in cN1 (22%) and cN2 (20%) disease. The overall concordance rate was 23%. The timing of staging did not correlate with pathological lymph node status on logistic regression (all P.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/328188https://dx.doi.org/urn:doi:10.1111/bju.16851reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::c36b6aa5d335654f02dfbc699ff7f8d22026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer |
| title |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer |
| spellingShingle |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer von Deimling, Markus|||0000-0002-9954-3413 cN+ Lymph node staging Computed tomography Radical cystectomy Template Urinary bladder neoplasms Urothelial cancer |
| title_short |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer |
| title_full |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer |
| title_fullStr |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer |
| title_full_unstemmed |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer |
| title_sort |
Impact of timing of computed tomography staging and patient factors on the detection of 'true' + bladder cancer |
| dc.creator.none.fl_str_mv |
von Deimling, Markus|||0000-0002-9954-3413 Furrer, Marc|||0000-0001-8847-6799 Pichler, Renate|||0000-0001-5286-9048 Maas, Moritz Tully, Karl Heinrich|||0000-0002-9499-0169 Mertens, Laura S.|||0000-0003-3317-6427 Taylor, Jacob Del Giudice, Francesco|||0000-0003-3865-5988 Li, Roger|||0000-0003-1274-7200 Gallioli, Andrea|||0000-0002-3316-5691 Albisinni, Simone|||0000-0001-5529-3064 Crocetto, Felice|||0000-0002-4315-7660 Velev, Maud Afferi, Luca|||0000-0002-5472-1933 Mari, Andrea|||0000-0001-9070-5706 Laukhtina, Ekaterina|||0000-0002-8953-0272 Fisch, Margit Spiess, Philippe E. Lotan, Yair|||0000-0001-5692-2723 Moschini, Marco|||0000-0002-3084-2458 Black, Peter C. Antonelli, Alessandro|||0000-0002-7455-8803 Kiss, Bernhard|||0000-0002-4691-556X Shariat, Shahrokh|||0000-0002-6627-6179 Pradere, Benjamin|||0000-0002-7768-8558 Bianchi, Alberto Longoni, Mattia Klemm, Jakob Singla, Nirmish |
| author |
von Deimling, Markus|||0000-0002-9954-3413 |
| author_facet |
von Deimling, Markus|||0000-0002-9954-3413 Furrer, Marc|||0000-0001-8847-6799 Pichler, Renate|||0000-0001-5286-9048 Maas, Moritz Tully, Karl Heinrich|||0000-0002-9499-0169 Mertens, Laura S.|||0000-0003-3317-6427 Taylor, Jacob Del Giudice, Francesco|||0000-0003-3865-5988 Li, Roger|||0000-0003-1274-7200 Gallioli, Andrea|||0000-0002-3316-5691 Albisinni, Simone|||0000-0001-5529-3064 Crocetto, Felice|||0000-0002-4315-7660 Velev, Maud Afferi, Luca|||0000-0002-5472-1933 Mari, Andrea|||0000-0001-9070-5706 Laukhtina, Ekaterina|||0000-0002-8953-0272 Fisch, Margit Spiess, Philippe E. Lotan, Yair|||0000-0001-5692-2723 Moschini, Marco|||0000-0002-3084-2458 Black, Peter C. Antonelli, Alessandro|||0000-0002-7455-8803 Kiss, Bernhard|||0000-0002-4691-556X Shariat, Shahrokh|||0000-0002-6627-6179 Pradere, Benjamin|||0000-0002-7768-8558 Bianchi, Alberto Longoni, Mattia Klemm, Jakob Singla, Nirmish |
| author_role |
author |
| author2 |
Furrer, Marc|||0000-0001-8847-6799 Pichler, Renate|||0000-0001-5286-9048 Maas, Moritz Tully, Karl Heinrich|||0000-0002-9499-0169 Mertens, Laura S.|||0000-0003-3317-6427 Taylor, Jacob Del Giudice, Francesco|||0000-0003-3865-5988 Li, Roger|||0000-0003-1274-7200 Gallioli, Andrea|||0000-0002-3316-5691 Albisinni, Simone|||0000-0001-5529-3064 Crocetto, Felice|||0000-0002-4315-7660 Velev, Maud Afferi, Luca|||0000-0002-5472-1933 Mari, Andrea|||0000-0001-9070-5706 Laukhtina, Ekaterina|||0000-0002-8953-0272 Fisch, Margit Spiess, Philippe E. Lotan, Yair|||0000-0001-5692-2723 Moschini, Marco|||0000-0002-3084-2458 Black, Peter C. Antonelli, Alessandro|||0000-0002-7455-8803 Kiss, Bernhard|||0000-0002-4691-556X Shariat, Shahrokh|||0000-0002-6627-6179 Pradere, Benjamin|||0000-0002-7768-8558 Bianchi, Alberto Longoni, Mattia Klemm, Jakob Singla, Nirmish |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
cN+ Lymph node staging Computed tomography Radical cystectomy Template Urinary bladder neoplasms Urothelial cancer |
| topic |
cN+ Lymph node staging Computed tomography Radical cystectomy Template Urinary bladder neoplasms Urothelial cancer |
| description |
To evaluate whether computed tomography (CT) scans should be performed before or after transurethral resection of bladder tumour (TURBT) for accurate lymph node staging in clinically lymph node-positive bladder cancer (BCa). Additionally, to identify patient factors that can aid in predicting lymph node metastasis. In this retrospective, multicentre study, we analysed patients with cN+ M0 BCa staged by CT and treated with upfront radical cystectomy (RC) and pelvic lymph node dissection. We stratified patients by the interval between TURBT and CT into three groups: (1) before TURBT; (2) within 30 days after TURBT; and (3) more than 30 days post-TURBT. Staging accuracy, defined as concordance between clinical and pathological lymph node status, was evaluated. We utilised logistic regression analyses to identify patient factors, including the optimal timing of staging, in predicting pathological lymph node status at RC. Among 183 patients with cN+ disease, 90 (49%) had pN0 disease at RC. Of these, 40, 36 and 14 were staged before TURBT, within 30 days after TURBT, and more than 30 days post-TURBT, respectively (P = 0.2). Pathological downstaging was most common in cN1 (22%) and cN2 (20%) disease. The overall concordance rate was 23%. The timing of staging did not correlate with pathological lymph node status on logistic regression (all P. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/328188 https://dx.doi.org/urn:doi:10.1111/bju.16851 |
| url |
https://ddd.uab.cat/record/328188 https://dx.doi.org/urn:doi:10.1111/bju.16851 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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