Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion
Introduction: The IMPACT BCN trial-a parallel-group randomized clinical trial where 1221 pregnant women at high risk for small-for-gestational age (SGA) newborns were randomly allocated at 19- to 23-week gestation into three groups: Mediterranean diet, Mindfulness-based Stress reduction or non-inter...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2024 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglês |
| OAI Identifier: | oai:ddd.uab.cat:311574 |
| Acesso em linha: | https://ddd.uab.cat/record/311574 https://dx.doi.org/urn:doi:10.1111/aogs.14874 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Fetal growth restriction Intrauterine growth restriction Magnetic resonance Mediterranean diet Mindfulness Placenta Placental insufficiency Placental MR Prenatal Stress reduction |
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Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion A subanalysis of the IMPACT BCN randomized clinical trial |
| title |
Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion |
| spellingShingle |
Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion Nakaki, Ayako|||0000-0002-4395-3878 Fetal growth restriction Intrauterine growth restriction Magnetic resonance Mediterranean diet Mindfulness Placenta Placental insufficiency Placental MR Prenatal Stress reduction |
| title_short |
Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion |
| title_full |
Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion |
| title_fullStr |
Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion |
| title_full_unstemmed |
Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion |
| title_sort |
Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusion |
| dc.creator.none.fl_str_mv |
Nakaki, Ayako|||0000-0002-4395-3878 Denaro, Eugenio Crimella, Maddalena Castellani, Roberta Vellvé, Kilian|||0000-0002-2376-7664 Izquierdo, Nora Basso, Annachiara Paules, Cristina|||0000-0001-6795-0367 Casas, Rosa|||0000-0002-0211-9166 Benitez, Leticia|||0000-0002-4950-036X Casas, Irene Larroya, Marta|||0000-0001-7929-6630 Genero, Mariona Castro Barquero, Sara|||0000-0002-6876-5443 Gomez-Gomez, A|||0000-0001-8172-1827 Pozo, Oscar J|||0000-0002-1735-9728 Vieta, Eduard|||0000-0002-0548-0053 Estruch, Ramón|||0000-0003-1260-4445 Nadal, Alfons Gratacós, Eduard|||0000-0002-7405-7224 Crovetto, Francesca|||0000-0003-0140-7411 Crispi, Fatima|||0000-0002-7422-5240 Youssef, Lina|||0000-0002-0554-5507 |
| author |
Nakaki, Ayako|||0000-0002-4395-3878 |
| author_facet |
Nakaki, Ayako|||0000-0002-4395-3878 Denaro, Eugenio Crimella, Maddalena Castellani, Roberta Vellvé, Kilian|||0000-0002-2376-7664 Izquierdo, Nora Basso, Annachiara Paules, Cristina|||0000-0001-6795-0367 Casas, Rosa|||0000-0002-0211-9166 Benitez, Leticia|||0000-0002-4950-036X Casas, Irene Larroya, Marta|||0000-0001-7929-6630 Genero, Mariona Castro Barquero, Sara|||0000-0002-6876-5443 Gomez-Gomez, A|||0000-0001-8172-1827 Pozo, Oscar J|||0000-0002-1735-9728 Vieta, Eduard|||0000-0002-0548-0053 Estruch, Ramón|||0000-0003-1260-4445 Nadal, Alfons Gratacós, Eduard|||0000-0002-7405-7224 Crovetto, Francesca|||0000-0003-0140-7411 Crispi, Fatima|||0000-0002-7422-5240 Youssef, Lina|||0000-0002-0554-5507 |
| author_role |
author |
| author2 |
Denaro, Eugenio Crimella, Maddalena Castellani, Roberta Vellvé, Kilian|||0000-0002-2376-7664 Izquierdo, Nora Basso, Annachiara Paules, Cristina|||0000-0001-6795-0367 Casas, Rosa|||0000-0002-0211-9166 Benitez, Leticia|||0000-0002-4950-036X Casas, Irene Larroya, Marta|||0000-0001-7929-6630 Genero, Mariona Castro Barquero, Sara|||0000-0002-6876-5443 Gomez-Gomez, A|||0000-0001-8172-1827 Pozo, Oscar J|||0000-0002-1735-9728 Vieta, Eduard|||0000-0002-0548-0053 Estruch, Ramón|||0000-0003-1260-4445 Nadal, Alfons Gratacós, Eduard|||0000-0002-7405-7224 Crovetto, Francesca|||0000-0003-0140-7411 Crispi, Fatima|||0000-0002-7422-5240 Youssef, Lina|||0000-0002-0554-5507 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Fetal growth restriction Intrauterine growth restriction Magnetic resonance Mediterranean diet Mindfulness Placenta Placental insufficiency Placental MR Prenatal Stress reduction |
| topic |
Fetal growth restriction Intrauterine growth restriction Magnetic resonance Mediterranean diet Mindfulness Placenta Placental insufficiency Placental MR Prenatal Stress reduction |
| description |
Introduction: The IMPACT BCN trial-a parallel-group randomized clinical trial where 1221 pregnant women at high risk for small-for-gestational age (SGA) newborns were randomly allocated at 19- to 23-week gestation into three groups: Mediterranean diet, Mindfulness-based Stress reduction or non-intervention-has demonstrated a positive effect of Mediterranean diet and Stress reduction in the prevention of SGA. However, the mechanism of action of these interventions remains still unclear. The aim of this study is to investigate the effect of Mediterranean diet and Stress reduction on placental volume and perfusion. Material and Methods: Participants in the Mediterranean diet group received monthly individual and group educational sessions, and free provision of extra-virgin olive oil and walnuts. Women in the Stress reduction group underwent an 8-week Stress reduction program adapted for pregnancy, consisting of weekly 2.5-h and one full-day sessions. Non-intervention group was based on usual care. Placental volume and perfusion were assessed in a subgroup of randomly selected women (n = 165) using magnetic resonance (MR) at 36-week gestation. Small placental volume was defined as MR estimated volume <10th centile. Perfusion was assessed by intravoxel incoherent motion. Results: While mean MR placental volume was similar among the study groups, both interventions were associated with a lower prevalence of small placental volume (3.9% Mediterranean diet and 5% stress reduction vs. 17% non-intervention; p = 0.03 and p = 0.04, respectively). Logistic regression showed that small placental volume was significantly associated with higher risk of SGA in both study groups (OR 7.48 [1.99-28.09] in Mediterranean diet and 20.44 [5.13-81.4] in Stress reduction). Mediation analysis showed that the effect of Mediterranean diet on SGA can be decomposed by a direct effect and an indirect effect (56.6%) mediated by a small placental volume. Similarly, the effect of Stress reduction on SGA is partially mediated (45.3%) by a small placental volume. Results on placental intravoxel incoherent motion perfusion fraction and diffusion coefficient were similar among the study groups. Conclusions: Structured interventions during pregnancy based on Mediterranean diet or Stress reduction are associated with a lower proportion of small placentas, which is consistent with the previously observed beneficial effects of these interventions on fetal growth. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/311574 https://dx.doi.org/urn:doi:10.1111/aogs.14874 |
| url |
https://ddd.uab.cat/record/311574 https://dx.doi.org/urn:doi:10.1111/aogs.14874 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
"la Caixa" Foundation https://doi.org/10.13039/100010434 LCF/BQ/DR19/11740018 "la Caixa" Foundation https://doi.org/10.13039/100010434 LCF/PR/GN18/10310003 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01422 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00675 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00073 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00246 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM19/00140 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00684 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 AC19/00100 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2021-048123-I |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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1869403427925131264 |
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Effect of Mediterranean diet or mindfulness-based stress reduction during pregnancy on placental volume and perfusionA subanalysis of the IMPACT BCN randomized clinical trialNakaki, Ayako|||0000-0002-4395-3878Denaro, EugenioCrimella, MaddalenaCastellani, RobertaVellvé, Kilian|||0000-0002-2376-7664Izquierdo, NoraBasso, AnnachiaraPaules, Cristina|||0000-0001-6795-0367Casas, Rosa|||0000-0002-0211-9166Benitez, Leticia|||0000-0002-4950-036XCasas, IreneLarroya, Marta|||0000-0001-7929-6630Genero, MarionaCastro Barquero, Sara|||0000-0002-6876-5443Gomez-Gomez, A|||0000-0001-8172-1827Pozo, Oscar J|||0000-0002-1735-9728Vieta, Eduard|||0000-0002-0548-0053Estruch, Ramón|||0000-0003-1260-4445Nadal, AlfonsGratacós, Eduard|||0000-0002-7405-7224Crovetto, Francesca|||0000-0003-0140-7411Crispi, Fatima|||0000-0002-7422-5240Youssef, Lina|||0000-0002-0554-5507Fetal growth restrictionIntrauterine growth restrictionMagnetic resonanceMediterranean dietMindfulnessPlacentaPlacental insufficiencyPlacental MRPrenatalStress reductionIntroduction: The IMPACT BCN trial-a parallel-group randomized clinical trial where 1221 pregnant women at high risk for small-for-gestational age (SGA) newborns were randomly allocated at 19- to 23-week gestation into three groups: Mediterranean diet, Mindfulness-based Stress reduction or non-intervention-has demonstrated a positive effect of Mediterranean diet and Stress reduction in the prevention of SGA. However, the mechanism of action of these interventions remains still unclear. The aim of this study is to investigate the effect of Mediterranean diet and Stress reduction on placental volume and perfusion. Material and Methods: Participants in the Mediterranean diet group received monthly individual and group educational sessions, and free provision of extra-virgin olive oil and walnuts. Women in the Stress reduction group underwent an 8-week Stress reduction program adapted for pregnancy, consisting of weekly 2.5-h and one full-day sessions. Non-intervention group was based on usual care. Placental volume and perfusion were assessed in a subgroup of randomly selected women (n = 165) using magnetic resonance (MR) at 36-week gestation. Small placental volume was defined as MR estimated volume <10th centile. Perfusion was assessed by intravoxel incoherent motion. Results: While mean MR placental volume was similar among the study groups, both interventions were associated with a lower prevalence of small placental volume (3.9% Mediterranean diet and 5% stress reduction vs. 17% non-intervention; p = 0.03 and p = 0.04, respectively). Logistic regression showed that small placental volume was significantly associated with higher risk of SGA in both study groups (OR 7.48 [1.99-28.09] in Mediterranean diet and 20.44 [5.13-81.4] in Stress reduction). Mediation analysis showed that the effect of Mediterranean diet on SGA can be decomposed by a direct effect and an indirect effect (56.6%) mediated by a small placental volume. Similarly, the effect of Stress reduction on SGA is partially mediated (45.3%) by a small placental volume. Results on placental intravoxel incoherent motion perfusion fraction and diffusion coefficient were similar among the study groups. Conclusions: Structured interventions during pregnancy based on Mediterranean diet or Stress reduction are associated with a lower proportion of small placentas, which is consistent with the previously observed beneficial effects of these interventions on fetal growth. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/311574https://dx.doi.org/urn:doi:10.1111/aogs.14874reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaIngléseng"la Caixa" Foundation https://doi.org/10.13039/100010434 LCF/BQ/DR19/11740018"la Caixa" Foundation https://doi.org/10.13039/100010434 LCF/PR/GN18/10310003Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01422Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00675Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00073Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00246Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM19/00140Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00684Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 AC19/00100Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FJC2021-048123-Iopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3115742026-06-06T12:50:31Z |
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15,81155 |