Endolysosomal cholesterol export: More than just NPC1

NPC1 plays a central role in cholesterol egress from endolysosomes, a critical step for maintaining intracellular cholesterol homeostasis. Despite recent advances in the field, the full repertoire of molecules and pathways involved in this process remains unknown. Emerging evidence suggests the exis...

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Detalles Bibliográficos
Autor: Lu, Albert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/215878
Acceso en línea:https://hdl.handle.net/2445/215878
Access Level:acceso abierto
Palabra clave:Colesterol
Glicoproteïnes
Cholesterol
Glycoproteins
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spelling Endolysosomal cholesterol export: More than just NPC1Lu, AlbertColesterolGlicoproteïnesCholesterolGlycoproteinsNPC1 plays a central role in cholesterol egress from endolysosomes, a critical step for maintaining intracellular cholesterol homeostasis. Despite recent advances in the field, the full repertoire of molecules and pathways involved in this process remains unknown. Emerging evidence suggests the existence of NPC1-independent, alternative routes. These may involve vesicular and non-vesicular mechanisms, as well as release of extracellular vesicles. Understanding the underlying molecular mechanisms that bypass NPC1 function could have important implications for the development of therapies for lysosomal storage disorders. Here we discuss how cholesterol may be exported from lysosomes in which NPC1 function is impaired.Wiley2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/215878Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/bies.202200111BioEssays, 2022, vol. 44, num.10, p. 1-12https://doi.org/10.1002/bies.202200111cc-by.nc (c) Lu, 2022http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2158782026-05-27T06:46:51Z
dc.title.none.fl_str_mv Endolysosomal cholesterol export: More than just NPC1
title Endolysosomal cholesterol export: More than just NPC1
spellingShingle Endolysosomal cholesterol export: More than just NPC1
Lu, Albert
Colesterol
Glicoproteïnes
Cholesterol
Glycoproteins
title_short Endolysosomal cholesterol export: More than just NPC1
title_full Endolysosomal cholesterol export: More than just NPC1
title_fullStr Endolysosomal cholesterol export: More than just NPC1
title_full_unstemmed Endolysosomal cholesterol export: More than just NPC1
title_sort Endolysosomal cholesterol export: More than just NPC1
dc.creator.none.fl_str_mv Lu, Albert
author Lu, Albert
author_facet Lu, Albert
author_role author
dc.subject.none.fl_str_mv Colesterol
Glicoproteïnes
Cholesterol
Glycoproteins
topic Colesterol
Glicoproteïnes
Cholesterol
Glycoproteins
description NPC1 plays a central role in cholesterol egress from endolysosomes, a critical step for maintaining intracellular cholesterol homeostasis. Despite recent advances in the field, the full repertoire of molecules and pathways involved in this process remains unknown. Emerging evidence suggests the existence of NPC1-independent, alternative routes. These may involve vesicular and non-vesicular mechanisms, as well as release of extracellular vesicles. Understanding the underlying molecular mechanisms that bypass NPC1 function could have important implications for the development of therapies for lysosomal storage disorders. Here we discuss how cholesterol may be exported from lysosomes in which NPC1 function is impaired.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/215878
url https://hdl.handle.net/2445/215878
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/bies.202200111
BioEssays, 2022, vol. 44, num.10, p. 1-12
https://doi.org/10.1002/bies.202200111
dc.rights.none.fl_str_mv cc-by.nc (c) Lu, 2022
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by.nc (c) Lu, 2022
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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