Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos

OBJECTIVES: 1. To asses the tolerance, efficacy and long-term effect of venom immunotherapy (VIT) and to monitor in vivo and in vitro changes after 5 years of treatment and subsequent follow-up. 2. To study the influence of VIT on specific immunoglobulin E (sIgE) to individual allergens before and a...

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Autor: Carballada González, Francisco Javier
Tipo de recurso: tesis doctoral
Fecha de publicación:2011
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:español
OAI Identifier:oai:minerva.usc.gal:10347/3372
Acceso en línea:http://hdl.handle.net/10347/3372
Access Level:acceso abierto
Palabra clave:Apis
Hymenoptera venom allergy
Venom immunotherapy
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spelling Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicosCarballada González, Francisco JavierApisHymenoptera venom allergyVenom immunotherapyOBJECTIVES: 1. To asses the tolerance, efficacy and long-term effect of venom immunotherapy (VIT) and to monitor in vivo and in vitro changes after 5 years of treatment and subsequent follow-up. 2. To study the influence of VIT on specific immunoglobulin E (sIgE) to individual allergens before and after three years of treatment. METHODS A total of 606 patients allergic to hymenoptera venom (467 to bee, 139 to wasp) were studied. All of them received VIT (Apis or Vespula. Two patients received an extract of Polistes dominulus). Cutaneous tests (ID) and sIgE were performed in all patients and in 35 of them, sIgE to main individual hymenoptera allergens (Api m 1, Api m 2, Ves v 1, Pol d 1, Ve v 2, Ves v 5 and Pol d 5) was measured before and after 3 years of treatment. RESULTS: The treatment was completed in 462 patients. During/after treatment 141/73 patients sensitized to Apis and 53/25 to Vespula suffered spontaneous re-stings. The 95,7% patients sensitized to Apis and 100% sensitized to Vespula suffered a local reaction or no-reaction. At the end of treatment, the cutaneous response (ID) and sIgE level to whole venom extract decreased significantly. Reductions in sIgE to main allergens were also observed after 3 years of treatment (Api m1: p <0.001; Api m2: p=0.0270; Ves V5: p=0.0234). CONCLUSIONS: The lack of anaphylactic reactions to spontaneous re-stings shows that VIT protected during the treatment and this efficacy was maintained up to 8 years after completing treatment in a real-world setting. Determination of sIgE to individual venom allergens may offer new perspectives in the diagnosis and follow-up of these patients.Boquete Paris, ManuelGonzález Quintela, Arturo20112011-08-2620112011-08-26doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfapplication/pdfhttp://hdl.handle.net/10347/3372reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2Esta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glinfo:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/33722026-06-15T12:47:27Z
dc.title.none.fl_str_mv Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
title Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
spellingShingle Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
Carballada González, Francisco Javier
Apis
Hymenoptera venom allergy
Venom immunotherapy
title_short Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
title_full Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
title_fullStr Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
title_full_unstemmed Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
title_sort Eficacia y seguridad de la inmunoterapia específica en pacientes alérgicos al veneno de himenópteros : influencia del tratamiento en la respuesta inmunológica al veneno y a sus componentes moleculares alergénicos
dc.creator.none.fl_str_mv Carballada González, Francisco Javier
author Carballada González, Francisco Javier
author_facet Carballada González, Francisco Javier
author_role author
dc.contributor.none.fl_str_mv Boquete Paris, Manuel
González Quintela, Arturo
dc.subject.none.fl_str_mv Apis
Hymenoptera venom allergy
Venom immunotherapy
topic Apis
Hymenoptera venom allergy
Venom immunotherapy
description OBJECTIVES: 1. To asses the tolerance, efficacy and long-term effect of venom immunotherapy (VIT) and to monitor in vivo and in vitro changes after 5 years of treatment and subsequent follow-up. 2. To study the influence of VIT on specific immunoglobulin E (sIgE) to individual allergens before and after three years of treatment. METHODS A total of 606 patients allergic to hymenoptera venom (467 to bee, 139 to wasp) were studied. All of them received VIT (Apis or Vespula. Two patients received an extract of Polistes dominulus). Cutaneous tests (ID) and sIgE were performed in all patients and in 35 of them, sIgE to main individual hymenoptera allergens (Api m 1, Api m 2, Ves v 1, Pol d 1, Ve v 2, Ves v 5 and Pol d 5) was measured before and after 3 years of treatment. RESULTS: The treatment was completed in 462 patients. During/after treatment 141/73 patients sensitized to Apis and 53/25 to Vespula suffered spontaneous re-stings. The 95,7% patients sensitized to Apis and 100% sensitized to Vespula suffered a local reaction or no-reaction. At the end of treatment, the cutaneous response (ID) and sIgE level to whole venom extract decreased significantly. Reductions in sIgE to main allergens were also observed after 3 years of treatment (Api m1: p <0.001; Api m2: p=0.0270; Ves V5: p=0.0234). CONCLUSIONS: The lack of anaphylactic reactions to spontaneous re-stings shows that VIT protected during the treatment and this efficacy was maintained up to 8 years after completing treatment in a real-world setting. Determination of sIgE to individual venom allergens may offer new perspectives in the diagnosis and follow-up of these patients.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-08-26
2011
2011-08-26
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/3372
url http://hdl.handle.net/10347/3372
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.gl
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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