Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question

The hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a complex and dynamic network of interactions across multiple cell types regulates HSC function. During the last years, it became progressively clearer that changes in the HSC niche are responsible for specific alterati...

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Authors: Matteini, Francesca, Mulaw, Medhanie A., Florian, Maria Carolina
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181793
Online Access:https://hdl.handle.net/2445/181793
Access Level:Open access
Keyword:Cèl·lules mare
Medul·la òssia
Envelliment
Stem cells
Bone marrow
Aging
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spelling Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old QuestionMatteini, FrancescaMulaw, Medhanie A.Florian, Maria CarolinaCèl·lules mareMedul·la òssiaEnvellimentStem cellsBone marrowAgingThe hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a complex and dynamic network of interactions across multiple cell types regulates HSC function. During the last years, it became progressively clearer that changes in the HSC niche are responsible for specific alterations of HSC behavior. The aging of the bone marrow (BM) microenvironment has been shown to critically contribute to the decline in HSC function over time. Interestingly, while upon aging some niche structures within the BM are degenerated and negatively affect HSC functionality, other niche cells and specific signals are preserved and essential to retaining HSC function and regenerative capacity. These new findings on the role of the aging BM niche critically depend on the implementation of new technical tools, developed thanks to transdisciplinary approaches, which bring together different scientific fields. For example, the development of specific mouse models in addition to coculture systems, new 3D-imaging tools, ossicles, and ex-vivo BM mimicking systems is highlighting the importance of new technologies to unravel the complexity of the BM niche on aging. Of note, an exponential impact in the understanding of this biological system has been recently brought by single-cell sequencing techniques, spatial transcriptomics, and implementation of artificial intelligence and deep learning approaches to data analysis and integration. This review focuses on how the aging of the BM niche affects HSCs and on the new tools to investigate the specific alterations occurring in the BM upon aging. All these new advances in the understanding of the BM niche and its regulatory function on HSCs have the potential to lead to novel therapeutical approaches to preserve HSC function upon aging and disease.Frontiers Media SA2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion21 p.application/pdfhttps://hdl.handle.net/2445/181793Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2021.738204Frontiers in Immunology, 2021, vol. 12, num. 738204https://doi.org/10.3389/fimmu.2021.738204cc by (c) Matteini, Francesca et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1817932026-05-29T05:05:01Z
dc.title.none.fl_str_mv Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
title Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
spellingShingle Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
Matteini, Francesca
Cèl·lules mare
Medul·la òssia
Envelliment
Stem cells
Bone marrow
Aging
title_short Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
title_full Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
title_fullStr Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
title_full_unstemmed Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
title_sort Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
dc.creator.none.fl_str_mv Matteini, Francesca
Mulaw, Medhanie A.
Florian, Maria Carolina
author Matteini, Francesca
author_facet Matteini, Francesca
Mulaw, Medhanie A.
Florian, Maria Carolina
author_role author
author2 Mulaw, Medhanie A.
Florian, Maria Carolina
author2_role author
author
dc.subject.none.fl_str_mv Cèl·lules mare
Medul·la òssia
Envelliment
Stem cells
Bone marrow
Aging
topic Cèl·lules mare
Medul·la òssia
Envelliment
Stem cells
Bone marrow
Aging
description The hematopoietic stem cell (HSC) niche is a specialized microenvironment, where a complex and dynamic network of interactions across multiple cell types regulates HSC function. During the last years, it became progressively clearer that changes in the HSC niche are responsible for specific alterations of HSC behavior. The aging of the bone marrow (BM) microenvironment has been shown to critically contribute to the decline in HSC function over time. Interestingly, while upon aging some niche structures within the BM are degenerated and negatively affect HSC functionality, other niche cells and specific signals are preserved and essential to retaining HSC function and regenerative capacity. These new findings on the role of the aging BM niche critically depend on the implementation of new technical tools, developed thanks to transdisciplinary approaches, which bring together different scientific fields. For example, the development of specific mouse models in addition to coculture systems, new 3D-imaging tools, ossicles, and ex-vivo BM mimicking systems is highlighting the importance of new technologies to unravel the complexity of the BM niche on aging. Of note, an exponential impact in the understanding of this biological system has been recently brought by single-cell sequencing techniques, spatial transcriptomics, and implementation of artificial intelligence and deep learning approaches to data analysis and integration. This review focuses on how the aging of the BM niche affects HSCs and on the new tools to investigate the specific alterations occurring in the BM upon aging. All these new advances in the understanding of the BM niche and its regulatory function on HSCs have the potential to lead to novel therapeutical approaches to preserve HSC function upon aging and disease.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181793
url https://hdl.handle.net/2445/181793
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2021.738204
Frontiers in Immunology, 2021, vol. 12, num. 738204
https://doi.org/10.3389/fimmu.2021.738204
dc.rights.none.fl_str_mv cc by (c) Matteini, Francesca et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Matteini, Francesca et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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