Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration

58 p.-2 fig.

Detalles Bibliográficos
Autores: Morán, María, Moreno-Lastres, David, Marín-Buera, Lorena, Arenas, Joaquín, Martín, Miguel Ángel, Ugalde, Cristina
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2012
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/377855
Acceso en línea:http://hdl.handle.net/10261/377855
Access Level:acceso abierto
Palabra clave:Mitochondria
Respiratory chain dysfunction
Assembly
Reactive oxygen species
Mitochondrial dynamics
Neurodegeneration
Free radicals
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spelling Mitochondrial respiratory chain dysfunction: Implications in neurodegenerationMorán, MaríaMoreno-Lastres, DavidMarín-Buera, LorenaArenas, JoaquínMartín, Miguel ÁngelUgalde, CristinaMitochondriaRespiratory chain dysfunctionAssemblyReactive oxygen speciesMitochondrial dynamicsNeurodegenerationFree radicals58 p.-2 fig.For decades mitochondria have been considered static round-shaped organelles in charge of energy production. In contrast, they are highly dynamic cellular components that undergo continuous cycles of fusion and fission influenced, for instance, by oxidative stress, cellular energy requirements, or the cell cycle state. New important functions beyond energy production have been attributed to mitochondria, such as the regulation of cell survival, because of their role in the modulation of apoptosis, autophagy, and aging. Primary mitochondrial diseases due to mutations in genes involved in these new mitochondrial functions and the implication of mitochondrial dysfunction in multifactorial human pathologies such as cancer, Alzheimer and Parkinson diseases, or diabetes has been demonstrated. Therefore, mitochondria are set at a central point of the equilibrium between health and disease, and a better understanding of mitochondrial functions will open new fields for exploring the roles of these mitochondrial pathways in human pathologies. This review dissects the relationships between activity and assembly defects of the mitochondrial respiratory chain, oxidative damage, and alterations in mitochondrial dynamics, with special focus on their implications for neurodegeneration.This study was supported by Grants PI08-0021 and PI11-00182 to C.U. and PI09-01359 to M.A.M. from the Ministerio de Industria y Competitividad de España, Instituto de Salud Carlos III (ISCIII). M.M. was supported by the Isabel Gemio Spanish Foundation for Muscular Dystrophies and Other Rare Diseases and CP11/00151 Ministerio de Industria y Competitividad de España, ISCIII. D.M.L. was supported by FI09/00320 Ministerio de Industria y Competitividad de España, ISCIII. M.A.M. is a recipient of the action “Intensificación de la actividad investigadora 2011” from the ISCIII/Agencia Pedro Laín Entralgo-Comunidad de Madrid.Peer reviewedMinisterio de Industria y Competitividad (España)Instituto de Salud Carlos IIIFundación Isabel GemioMorán, María [0000-0001-5408-7189]Arenas, Joaquín [0000-0002-2877-5049]Martín, Miguel Ángel [0000-0003-4741-772X]Ugalde, Cristina [0000-0002-9742-1877]202520252012info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/377855reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.freeradbiomed.2012.05.009Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3778552026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
title Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
spellingShingle Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
Morán, María
Mitochondria
Respiratory chain dysfunction
Assembly
Reactive oxygen species
Mitochondrial dynamics
Neurodegeneration
Free radicals
title_short Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
title_full Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
title_fullStr Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
title_full_unstemmed Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
title_sort Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
dc.creator.none.fl_str_mv Morán, María
Moreno-Lastres, David
Marín-Buera, Lorena
Arenas, Joaquín
Martín, Miguel Ángel
Ugalde, Cristina
author Morán, María
author_facet Morán, María
Moreno-Lastres, David
Marín-Buera, Lorena
Arenas, Joaquín
Martín, Miguel Ángel
Ugalde, Cristina
author_role author
author2 Moreno-Lastres, David
Marín-Buera, Lorena
Arenas, Joaquín
Martín, Miguel Ángel
Ugalde, Cristina
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Industria y Competitividad (España)
Instituto de Salud Carlos III
Fundación Isabel Gemio
Morán, María [0000-0001-5408-7189]
Arenas, Joaquín [0000-0002-2877-5049]
Martín, Miguel Ángel [0000-0003-4741-772X]
Ugalde, Cristina [0000-0002-9742-1877]
dc.subject.none.fl_str_mv Mitochondria
Respiratory chain dysfunction
Assembly
Reactive oxygen species
Mitochondrial dynamics
Neurodegeneration
Free radicals
topic Mitochondria
Respiratory chain dysfunction
Assembly
Reactive oxygen species
Mitochondrial dynamics
Neurodegeneration
Free radicals
description 58 p.-2 fig.
publishDate 2012
dc.date.none.fl_str_mv 2012
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/377855
url http://hdl.handle.net/10261/377855
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.freeradbiomed.2012.05.009
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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