Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata

17 páginas, 6 figuras, 4 tablas

Detalles Bibliográficos
Autores: Cano Argüelles, Ana Laura, Piloto-Sardiñas, Elianne, Maitre, Apolline, Mateos-Hernández, Lourdes, Maye, Jennifer, Wu-Chuang, Alejandra, Abuin-Denis, Lianet, Obregón, Dasiel, Bamgbose, Timothy, Oleaga, Ana, Cabezas-Cruz, Alejandro, Pérez Sánchez, Ricardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/366680
Acceso en línea:http://hdl.handle.net/10261/366680
https://api.elsevier.com/content/abstract/scopus_id/85201547090
Access Level:acceso abierto
Palabra clave:Ornithodoros moubata
Anti‐microbiota vaccine
Community assembly
Tick microbiome
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spelling Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubataCano Argüelles, Ana LauraPiloto-Sardiñas, ElianneMaitre, ApollineMateos-Hernández, LourdesMaye, JenniferWu-Chuang, AlejandraAbuin-Denis, LianetObregón, DasielBamgbose, TimothyOleaga, AnaCabezas-Cruz, AlejandroPérez Sánchez, RicardoOrnithodoros moubataAnti‐microbiota vaccineCommunity assemblyTick microbiomeOrnithodoros moubata17 páginas, 6 figuras, 4 tablasThe Ornithodoros moubata (Om) soft tick, a vector for diseases like tick-borne human relapsing fever and African swine fever, poses challenges to conventional control methods. With diminishing insecticide efficacy, harnessing the tick's microbiota through innovative approaches like microbiota-driven vaccination emerges as a promising strategy for sustainable and targeted disease control. This study investigated the intricate relationship between Pseudomonas, a keystone taxon in the Om microbiome, and its impact on tick fitness, microbiome structure and network dynamics. Utilizing in silico analyses and empirical vaccination experiments, the role of Pseudomonas within microbial networks in the tick midguts (MG) and salivary glands (SG) of Om was studied. Additionally, the consequences of anti-microbiota vaccines targeting Pseudomonas and Lactobacillus on tick fitness, microbiome diversity and community assembly were explored. The result of the study shows that in Om, Pseudomonas plays a central role in microbial networks, influencing keystone species despite being categorized as peripheral (interacting with 47 different taxa, 13 of which are keystone species). Anti-microbiota vaccination targeting Pseudomonas and Lactobacillus yields distinct effects on tick fitness, with Pseudomonas vaccination significantly impacting female tick survival, while Lactobacillus significantly reduced oviposition and fertility. Microbiome changes post-vaccination reveal diversity alterations, emphasizing the impact of vaccine choice. Community assembly dynamics and network robustness analyses highlight Pseudomonas' pivotal role, in influencing topological features and network resilience. The findings of the study provide comprehensive insights into the intricate dynamics of Om microbial networks and the potential of targeted microbiota-driven vaccines for tick control.Agence Nationale de la Recherche, Grant/Award Number: ANR-10-LABX-62-IBEID; European Regional Development Fund, Grant/Award Number: PID2022-136644OB-I00. In addition, ALC-A was supported by project ‘CLU-2019-05-IRNASA/CSIC Unit of Excellence’, granted by the Junta de Castilla y León and co-financed by the European Union (ERDF).Peer reviewedJohn Wiley & SonsAgence Nationale de la Recherche (France)Junta de Castilla y LeónCano Argüelles, Ana Laura [0000-0002-1056-8439]Oleaga, Ana [0000-0002-8019-7354]Pérez Sánchez, Ricardo [0000-0001-8875-439X]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/366680https://api.elsevier.com/content/abstract/scopus_id/85201547090reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésCano-Argüelles, A. L. (2025). Analysis of the tick-host interface and development of vaccines against Ornithodoros moubata. http://hdl.handle.net/10261/414435http://dx.doi.org/10.1111/mec.17506Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3666802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
title Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
spellingShingle Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
Cano Argüelles, Ana Laura
Ornithodoros moubata
Anti‐microbiota vaccine
Community assembly
Tick microbiome
Ornithodoros moubata
title_short Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
title_full Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
title_fullStr Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
title_full_unstemmed Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
title_sort Microbiota-driven vaccination in soft ticks: Implications for survival, fitness and reproductive capabilities in Ornithodoros moubata
dc.creator.none.fl_str_mv Cano Argüelles, Ana Laura
Piloto-Sardiñas, Elianne
Maitre, Apolline
Mateos-Hernández, Lourdes
Maye, Jennifer
Wu-Chuang, Alejandra
Abuin-Denis, Lianet
Obregón, Dasiel
Bamgbose, Timothy
Oleaga, Ana
Cabezas-Cruz, Alejandro
Pérez Sánchez, Ricardo
author Cano Argüelles, Ana Laura
author_facet Cano Argüelles, Ana Laura
Piloto-Sardiñas, Elianne
Maitre, Apolline
Mateos-Hernández, Lourdes
Maye, Jennifer
Wu-Chuang, Alejandra
Abuin-Denis, Lianet
Obregón, Dasiel
Bamgbose, Timothy
Oleaga, Ana
Cabezas-Cruz, Alejandro
Pérez Sánchez, Ricardo
author_role author
author2 Piloto-Sardiñas, Elianne
Maitre, Apolline
Mateos-Hernández, Lourdes
Maye, Jennifer
Wu-Chuang, Alejandra
Abuin-Denis, Lianet
Obregón, Dasiel
Bamgbose, Timothy
Oleaga, Ana
Cabezas-Cruz, Alejandro
Pérez Sánchez, Ricardo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agence Nationale de la Recherche (France)
Junta de Castilla y León
Cano Argüelles, Ana Laura [0000-0002-1056-8439]
Oleaga, Ana [0000-0002-8019-7354]
Pérez Sánchez, Ricardo [0000-0001-8875-439X]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ornithodoros moubata
Anti‐microbiota vaccine
Community assembly
Tick microbiome
Ornithodoros moubata
topic Ornithodoros moubata
Anti‐microbiota vaccine
Community assembly
Tick microbiome
Ornithodoros moubata
description 17 páginas, 6 figuras, 4 tablas
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/366680
https://api.elsevier.com/content/abstract/scopus_id/85201547090
url http://hdl.handle.net/10261/366680
https://api.elsevier.com/content/abstract/scopus_id/85201547090
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cano-Argüelles, A. L. (2025). Analysis of the tick-host interface and development of vaccines against Ornithodoros moubata. http://hdl.handle.net/10261/414435
http://dx.doi.org/10.1111/mec.17506
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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